Thermodynamics and kinetics of aqueous ferric phosphate complex formation

1985 ◽  
Vol 24 (20) ◽  
pp. 3290-3297 ◽  
Author(s):  
Richard B. Wilhelmy ◽  
Ramesh C. Patel ◽  
Egon Matijevic
Keyword(s):  
Complex Formation ◽  
Phosphate Complex ◽  
Thermodynamics And Kinetics ◽  
Ferric Phosphate ◽  
Kinetics Of

Open-chain polyethers. Influence of aromatic donor end groups on thermodynamics and kinetics of alkali metal ion complex formation

1979 ◽  
Vol 101 (10) ◽  
pp. 2588-2598 ◽  
Author(s):  
Burkhard Tuemmler ◽  
Guenter Maass ◽  
Fritz Voegtle ◽  
Heinz Sieger ◽  
Ulrich Heimann ◽  
...  
Keyword(s):  
Complex Formation ◽  
Alkali Metal ◽  
Metal Ion ◽  
Open Chain ◽  
Alkali Metal Ion ◽  
Thermodynamics And Kinetics ◽  
End Groups ◽  
Aromatic Donor ◽  
Kinetics Of ◽  
Metal Ion Complex

scholarly journals A Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics underlying Catalytic Efficiency

2021 ◽  
Author(s):  
Charu Chaudhry
Keyword(s):  
Mathematical Model ◽  
Complex Formation ◽  
Chemical Biology ◽  
Ternary Complex ◽  
E3 Ligase ◽  
Catalytic Efficiency ◽  
Binding Affinities ◽  
Thermodynamics And Kinetics ◽  
Ternary Complex Formation ◽  
Kinetics Of

Proteolysis targeting chimeras (PROTACs), heterobifunctional protein degraders, have emerged as an exciting and transformative technology in chemical biology and drug discovery to degrade disease-causing proteins through co-opting of the ubiquitin-proteosome system (UPS). Here we develop a mechanistic mathematical model for the use of irreversible covalent chemistry in targeted protein degradation (TPD), either to the target protein of interest (POI) or E3 ligase ligand, considering the thermodynamic and kinetic factors governing ternary complex formation, ubiquitination, and degradation through the UPS. We highlight key advantages of covalency to POI and E3 ligase, and the underlying theoretical basis in the TPD reaction framework. We further identify regimes where covalency can serve to overcome weak binary binding affinities and improve kinetics of ternary complex formation and degradation. Our results highlight the enhanced catalytic efficiency of covalent E3 PROTACs and thus their potential to improve the degradation of fast turnover targets.

Irradiation behavior of pyrolytic silicon carbide

1983 ◽  
Vol 41 ◽  
pp. 72-73
Author(s):  
R. J. Lauf
Keyword(s):  
Silicon Carbide ◽  
Fission Products ◽  
Thermodynamics And Kinetics ◽  
Neutron Fluences ◽  
Fuel Particles ◽  
Sic Coatings ◽  
Irradiation Behavior ◽  
Kinetics Of ◽  
Htgr Fuel

Fuel particles for the High-Temperature Gas-Cooled Reactor (HTGR) contain a layer of pyrolytic silicon carbide to act as a miniature pressure vessel and primary fission product barrier. Optimization of the SiC with respect to fuel performance involves four areas of study: (a) characterization of as-deposited SiC coatings; (b) thermodynamics and kinetics of chemical reactions between SiC and fission products; (c) irradiation behavior of SiC in the absence of fission products; and (d) combined effects of irradiation and fission products. This paper reports the behavior of SiC deposited on inert microspheres and irradiated to fast neutron fluences typical of HTGR fuel at end-of-life.

Comparative Labelling and Biokinetic Studies of 99mTc-EDTA(Sn) and 99mTc-DTPA(Sn)

1977 ◽  
Vol 16 (01) ◽  
pp. 30-35 ◽  
Author(s):  
N. Agha ◽  
R. B. R. Persson
Keyword(s):  
Complex Formation ◽  
Significant Influence ◽  
Room Temperature ◽  
Ph Value ◽  
Maximum Activity ◽  
Reduction Step ◽  
Labelling Yield ◽  
Different Temperatures ◽  
Kinetics Of

SummaryGelchromatography column scanning has been used to study the fractions of 99mTc-pertechnetate, 99mTcchelate and reduced hydrolyzed 99mTc in preparations of 99mTc-EDTA(Sn) and 99mTc-DTPA(Sn). The labelling yield of 99mTc-EDTA(Sn) chelate was as high as 90—95% when 100 μmol EDTA · H4 and 0.5 (Amol SnCl2 was incubated with 10 ml 99mTceluate for 30—60 min at room temperature. The study of the influence of the pH-value on the fraction of 99mTc-EDTA shows that pH 2.8—2.9 gave the best labelling yield. In a comparative study of the labelling kinetics of 99mTc-EDTA(Sn) and 99mTc- DTPA(Sn) at different temperatures (7, 22 and 37°C), no significant influence on the reduction step was found. The rate constant for complex formation, however, increased more rapidly with increased temperature for 99mTc-DTPA(Sn). At room temperature only a few minutes was required to achieve a high labelling yield with 99mTc-DTPA(Sn) whereas about 60 min was required for 99mTc-EDTA(Sn). Comparative biokinetic studies in rabbits showed that the maximum activity in kidneys is achieved after 12 min with 99mTc-EDTA(Sn) but already after 6 min with 99mTc-DTPA(Sn). The long-term disappearance of 99mTc-DTPA(Sn) from the kidneys is about five times faster than that for 99mTc-EDTA(Sn).

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