Binding of Copper(II) to the Cyclic Octapeptide Patellamide D

1994 ◽  
Vol 33 (10) ◽  
pp. 2280-2289 ◽  
Author(s):  
Anna L. van den Brenk ◽  
David P. Fairlie ◽  
Graeme R. Hanson ◽  
Lawrence R. Gahan ◽  
Clifford J. Hawkins ◽  
...  
Keyword(s):  
Cyclic Octapeptide

Axinellin C, a proline-rich cyclic octapeptide isolated from the Fijian marine sponge Stylotella aurantium

Tetrahedron ◽  
2002 ◽  
Vol 58 (39) ◽  
pp. 7863-7868 ◽  
Author(s):  
Jioji N. Tabudravu ◽  
Linda A. Morris ◽  
J. Jantina Kettenes-van den Bosch ◽  
Marcel Jaspars
Keyword(s):  
Marine Sponge ◽  
Cyclic Octapeptide

scholarly journals Structure–Activity Relationship of RGD-Containing Cyclic Octapeptide and αvβ3 Integrin Allows for Rapid Identification of a New Peptide Antagonist

2020 ◽  
Vol 21 (9) ◽  
pp. 3076 ◽  
Author(s):  
Aaron Silva ◽  
Wenwu Xiao ◽  
Yan Wang ◽  
Wei Wang ◽  
Heng Wei Chang ◽  
...  
Keyword(s):  
Rational Design ◽  
Tumor Imaging ◽  
Screening Method ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Sequence Motif ◽  
Αvβ3 Integrin ◽  
Structure Activity ◽  
Cyclic Octapeptide

The αvβ3 integrin, a receptor for many extracellular matrix proteins with RGD-sequence motif, is involved in multiple physiological processes and highly expressed in tumor cells, therefore making it a target for cancer therapy and tumor imaging. Several RGD-containing cyclic octapeptide (named LXW analogs) were screened as αvβ3 antagonists with dramatically different binding affinity, and their structure–activity relationship (SAR) remains elusive. We performed systematic SAR studies and optimized LXW analogs to improve antagonistic potency. The NMR structure of LXW64 was determined and docked to the integrin. Structural comparison and docking studies suggested that the hydrophobicity and aromaticity of the X7 amino acid are highly important for LXW analogs binding to the integrin, a potential hydrophobic pocket on the integrin surface was proposed to play a role in stabilizing the peptide binding. To develop a cost-efficient and fast screening method, computational docking was performed on LXW analogs and compared with in vitro screening. A consistency within the results of both methods was found, leading to the continuous optimization and testing of LXW mutants via in silico screening. Several new LXW analogs were predicted as the integrin antagonists, one of which—LXZ2—was validated by in vitro examination. Our study provides new insight into the RGD recognition specificity and valuable clues for rational design of novel αvβ3 antagonists.

scholarly journals The Revised Structure of the Cyclic Octapeptide Surugamide A

2019 ◽  
Vol 67 (5) ◽  
pp. 476-480 ◽  
Author(s):  
Kenichi Matsuda ◽  
Takefumi Kuranaga ◽  
Ayae Sano ◽  
Akihiro Ninomiya ◽  
Kentaro Takada ◽  
...  
Keyword(s):  
Cyclic Octapeptide

scholarly journals Anomalous dynamics of water at the octopeptide lanreotide surface

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 33903-33910
Author(s):  
Florian Pinzan ◽  
Franck Artzner ◽  
Aziz Ghoufi
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Water Dynamics ◽  
Atomistic Simulations ◽  
Hydration State ◽  
Dynamics Simulations ◽  
Anomalous Dynamics ◽  
Cyclic Octapeptide

Molecular dynamics simulations of a hydrated mutated lanreotide, a cyclic octapeptide, were carried out to characterize its hydration state. We studied the water dynamics close to the peptide using atomistic simulations.

Studies of the synthesis, immunology, and cytotoxicity of a cyclic octapeptide corresponding to TNF-.alpha.-(59-66)

1993 ◽  
Vol 36 (26) ◽  
pp. 4302-4307 ◽  
Author(s):  
Leung Sheh ◽  
Hsou Hung Lin ◽  
Kee Ching G. Jeng ◽  
Chia Fu Chen
Keyword(s):  
Tnf Alpha ◽  
Cyclic Octapeptide

Synthesis of Nanotubule-Forming Cyclic Octapeptides via an Fmoc Strategy

1998 ◽  
Vol 51 (7) ◽  
pp. 535 ◽  
Author(s):  
Martina E. Polaskova ◽  
John N. Lambert ◽  
Nicholas J. Ede
Keyword(s):  
Aqueous Solutions ◽  
Infrared Absorption ◽  
Structural Studies ◽  
Protection Strategy ◽  
Fmoc Chemistry ◽  
Orthogonal Protection ◽  
Fmoc Strategy ◽  
Cyclic Octapeptide ◽  
Head To Tail Cyclization ◽  
Hydrogen Bonded

New syndiotactic cyclic octapeptides, namely cyclo(–D-Phe-L-Asp–D-Phe–L-Asn–D-Phe–L-Asp–D-Phe–L-Asn–) (1) and cyclo(–D-N-MeAla–L-Asp–D-N-MeAla–L-Asn–D-N-MeAla–L-Asp–D-N-MeAla–L-Asn–) (2), have been prepared, and preliminary structural studies have been conducted. The synthesis of the linear peptides was performed by using Fmoc chemistry, and head-to-tail cyclization was accomplished by using an orthogonal protection strategy and a support-bound cyclization step. Acidification of aqueous solutions of cyclic octapeptide (1) initiated formation of needlelike crystals whose morphology and infrared absorption behaviour suggested that they were hydrogen-bonded nanotubular aggregates of (1).

Total Synthesis of Proline-Rich Cyclic Octapeptide Stylissamide X

2015 ◽  
Vol 51 (3) ◽  
pp. 523-526 ◽  
Author(s):  
Ting Huang ◽  
Yan Zou ◽  
Mao-cheng Wu ◽  
Qing-jie Zhao ◽  
Hong-gang Hu
Keyword(s):  
Total Synthesis ◽  
Cyclic Octapeptide

Cyclic Peptides from Higher Plants, Part 15, Pseudostellarin H, a New Cyclic Octapeptide from Pseudostellaria heterophylla

1995 ◽  
Vol 58 (6) ◽  
pp. 943-947 ◽  
Author(s):  
Hiroshi Morita ◽  
Takashi Kayashita ◽  
Koichi Takeya ◽  
Hideji Itokawa
Keyword(s):  
Cyclic Peptides ◽  
Higher Plants ◽  
Pseudostellaria Heterophylla ◽  
Cyclic Octapeptide

Regioisomeric Control Induced by DABCO Coordination to Rotatable Self-Assembled Bis- and Tetraporphyrin α,γ-Cyclic Octapeptide Dimers

2010 ◽  
Vol 17 (4) ◽  
pp. 1220-1229 ◽  
Author(s):  
Laura P. Hernández-Eguía ◽  
Roberto J. Brea ◽  
Luis Castedo ◽  
Pablo Ballester ◽  
Juan R. Granja
Keyword(s):  
Self Assembled ◽  
Cyclic Octapeptide
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