Vitamin B6 model reactions. 4. Stereoelectronic catalysis of carbon-hydrogen bond-breaking reactions and crystal and molecular structure of tetramethylammonium bis(pyridoxylideneglycinato)cobaltate(III)-4.5-water

1991 ◽  
Vol 30 (14) ◽  
pp. 2911-2916 ◽  
Author(s):  
Andrew G. Sykes ◽  
Raymond D. Larsen ◽  
James R. Fischer ◽  
Edwin H. Abbott
Keyword(s):  
Molecular Structure ◽  
Hydrogen Bond ◽  
Vitamin B6 ◽  
Crystal And Molecular Structure ◽  
Bond Breaking ◽  
Model Reactions

The Crystal and Molecular Structure of Butorphanol Hydrogen Tartrate

1994 ◽  
Vol 59 (6) ◽  
pp. 1361-1367 ◽  
Author(s):  
Alexandr Jegorov ◽  
Roman Sobotík ◽  
Svetlana Pakhomova ◽  
Jan Ondráček ◽  
Jiří Novotný ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
Crystal And Molecular Structure ◽  
Direct Methods ◽  
Chair Conformation ◽  
Triclinic Space Group ◽  
Space Group

The structure of butorphanol hydrogen tartrate {(9R,13S,14S)-(-)-17-(cyclobutylmethyl)morphinan-3,14-diol (2S,3S)-(-)-hydrogen tartrate} (C21H29NO2 .C4H6O6) was solved by direct methods and refined anisotropically to the R value of 0.029 for 2 069 observed reflections. The title morphine analogue crystallizes in the triclinic space group P1 with lattice parameters a = 7.620(1), b = 9.140(1), c = 9.591(1) Å, α = 105.48(1), β = 112.91(1), γ = 84.29(1)°, Z = 1. The butorphanol B ring possesses the 3E envelope conformation with small 3H2 distortion, C and D rings have a regular chair conformation. The intramolecular N17-H17...O2 hydrogen bond is observed in crystal structure of the title compound. The butorphanol and hydrogen tartrate molecules are joined together by means of O2-H(O2)...O7, O1-H(O1)...O7' and O3-H(O3)...O8" hydrogen bonds to form networks.

scholarly journals Sila-Pharmaka, 14. Mitt. Darstellung und Eigenschaften sowie Kristall-und Molekülstruktur von Sila-Difenidol /Sila-Drugs, 14th Communication Preparation and Properties as well as Crystal and Molecular Structure of Sila-Difenidol

1979 ◽  
Vol 34 (9) ◽  
pp. 1279-1285 ◽  
Author(s):  
R. Tacke ◽  
M. Strecker ◽  
W. S. Sheldrick ◽  
E. Heeg ◽  
B. Berndt ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Hydrogen Bond ◽  
Mass Spectroscopy ◽  
Crystal And Molecular Structure ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
H Nmr ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract Sila-difenidol (6b), a sila-analogue of the drug difenidol (6a), was synthesized according to Scheme 1. 6b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, 1H NMR and mass spectroscopy. 6 b crystallizes orthorhombic P212121 with a = 11.523(1), b = 14.366(4), c = 11.450(1) Å, Z = 4, Dber = 1.14 gcm-3. The structure was refined to R = 0.050 for 1897 reflexions. A strong nearly linear intramolecular O-H···N hydrogen bond of 2.685 Å is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported.

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