Modeling pH and Ionic Strength Effects on Proton and Calcium Complexation of Fulvic Acid:  A Tool for Drinking Water-NOM Studies

1997 ◽  
Vol 31 (3) ◽  
pp. 765-770 ◽  
Author(s):  
Purnendu Bose ◽  
David A. Reckhow
2020 ◽  
Vol 108 (7) ◽  
pp. 591
Author(s):  
Guodong Sheng ◽  
Jun Hu ◽  
Han Jing ◽  
Shitong Yang ◽  
Xuemei Ren ◽  
...  

2010 ◽  
Vol 98 (1) ◽  
Author(s):  
Qiao Hui Fan ◽  
M. L. Zhang ◽  
Y. Y. Zhang ◽  
K. F. Ding ◽  
Z. Q. Yang ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Orsolya Palócz ◽  
Géza Szita ◽  
György Csikó

The intestinal epithelium is the first determining barrier to the drugs administered per os. Cytochrome P450 (CYP) enzymes are substantial in the initial step of xenobiotic metabolism; therefore, intestinal CYP enzyme activities could be an important influencing factor of the oral utilization of xenobiotic substances. In this study, the effect of four drinking water supplements on CYP mRNA levels of porcine intestinal epithelial cells was examined. Further goal of the study is to describe the effect of these feed additives on the proinflammatory response of the LPS-treated enterocytes. The nontransformed porcine intestinal epithelial cells (IPEC-J2) were grown on six-well polyester membrane inserts. Cell cultures were treated with LPS (10 μg/ml), β-glucan (5 and 50 μg/ml), sanguinarine-containing additive (5 and 50 μg/ml), drinking water acidifier (0.1 and 1 μl/ml), and fulvic acid (25 and 250 μg/ml) for 1 hour. Cells were washed with culture medium and incubated for additional 1 h before total RNA isolation. IL-6, IL-8, TNF-α, HSP70, CYP1A1, CYP1A2, and CYP3A29 mRNA levels were measured. The LPS treatment upregulated the gene expression of IL-8 and TNF-α. The relative gene expression of IL-6 remained unchanged and TNF-α and HSP70 were downregulated after the treatment with each feed additive. CYP1A1 and CYP1A2 expressions increased after sanguinarine-containing solution, fulvic acid, and drinking water acidifier treatment. None of the treatments changed the gene expression of CYP3A29, responsible for the metabolism of the majority of drug substances used in swine industry. The feed additive substances inhibited the expression of proinflammatory mediators HSP70 and TNF-α; however, β-glucan and fulvic acid elevated the production of the chemokine IL-8 mRNA in endotoxin-treated enterocytes. All acidic supplements increased the expression of CYP1A1 gene; their constituents may serve as a ligand of CYP1A1 nuclear receptors.


2005 ◽  
Vol 39 (14) ◽  
pp. 5319-5326 ◽  
Author(s):  
Iso Christl ◽  
Axel Metzger ◽  
Ilona Heidmann ◽  
Ruben Kretzschmar
Keyword(s):  

2011 ◽  
Vol 11 (6) ◽  
pp. 668-674 ◽  
Author(s):  
B. Q. Zhao ◽  
C. P. Huang ◽  
S. Y. Chen ◽  
D. S. Wang ◽  
T. Li ◽  
...  

Natural organic matter (NOM) plays a significant role in the fouling of ultrafiltration membranes in drinking water treatment processes. For a better understanding of the interaction between fractional components of NOM and polysulfone (PS) ultrafiltration membranes used for drinking water treatment, fouling and especially the physically irreversible fouling of natural organic matter were investigated. Resin fractionation, fluorescence excitation–emission matrix (EEM) spectroscopy, fourier transform infrared spectroscopy (FTIR), contact angle and a scanning electron microscope (SEM) were employed to identify the potential foulants. The results showed that humic acid and fulvic acid of small size were likely to permeate the membrane, while the hydrophobic fraction of humic and fulvic acid and aromatic proteins tended to be rejected and retained. Organic compounds such as proteins, humic substances, and polysaccharide-like materials, were all detected in the fouling layer. The physically irreversible fouling of the PS membrane seemed to be mainly attributed to the hydrophobic fraction of humic substances.


2006 ◽  
Vol 64 (4) ◽  
pp. 455-461 ◽  
Author(s):  
Sh.M. Yu ◽  
A.P. Ren ◽  
Ch.L. Chen ◽  
Y.X. Chen ◽  
X. Wang

Sign in / Sign up

Export Citation Format

Share Document