Evaluation of Liposome−Water Partitioning for Predicting Bioaccumulation Potential of Hydrophobic Organic Chemicals

2009 ◽  
Vol 43 (23) ◽  
pp. 8854-8859 ◽  
Author(s):  
Stephan A. van der Heijden ◽  
Michiel T. O. Jonker
Keyword(s):  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
Water Partitioning

Factors Affecting Bioconcentration of Trace Organic Contamination in Waters

1989 ◽  
Vol 21 (2) ◽  
pp. 147-150 ◽  
Author(s):  
D. W. Hawker ◽  
D. W. Connell
Keyword(s):  
Molecular Weight ◽  
Bioconcentration Factor ◽  
Aqueous Solubility ◽  
Organic Chemicals ◽  
Organic Contamination ◽  
Hydrophobic Organic Chemicals ◽  
Factors Affecting ◽  
Water Partition Coefficient ◽  
Physicochemical Factors ◽  
Trace Organic

The influence of some important biological and physicochemical factors on the bioconcentration of hydrophobic organic chemicals is outlined. For non-ionizable, persistent compounds the bioconcentration factor can be related to a compound's octanol/water partition coefficient, aqueous solubility and molecular weight, while the lipid content of an organism also affects the bioconcentration potential of these compounds. The effect of ionization and biodegradation of organic chemicals on bioconcentration is also discussed.

A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

2015 ◽  
Vol 536 ◽  
pp. 279-287 ◽  
Author(s):  
Markus Brinkmann ◽  
Marko Freese ◽  
Jan-Dag Pohlmann ◽  
Ulrike Kammann ◽  
Thomas G. Preuss ◽  
...  
Keyword(s):  
Anguilla Anguilla ◽  
European Eel ◽  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
Physiologically Based

In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals

2017 ◽  
Vol 36 (7) ◽  
pp. 1934-1946 ◽  
Author(s):  
Yung-Shan Lee ◽  
Justin C. Lo ◽  
S.Victoria Otton ◽  
Margo M. Moore ◽  
Chris J. Kennedy ◽  
...  
Keyword(s):  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
In Vivo Extrapolation
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