Simple, Rapid Zebrafish Larva Bioassay for Assessing the Potential of Chemical Pollutants and Drugs to Disrupt Thyroid Gland Function

2009 ◽  
Vol 43 (17) ◽  
pp. 6844-6850 ◽  
Author(s):  
Demetrio Raldúa ◽  
Patrick J. Babin
Keyword(s):  
Thyroid Gland ◽  
Zebrafish Larva ◽  
Thyroid Gland Function ◽  
Chemical Pollutants ◽  
Gland Function

scholarly journals Thyroid Hormone Deficiency Before the Onset of Hearing Causes Irreversible Damage to Peripheral and Central Auditory Systems

2000 ◽  
Vol 83 (5) ◽  
pp. 3101-3112 ◽  
Author(s):  
Marlies Knipper ◽  
Christoph Zinn ◽  
Hannes Maier ◽  
Mark Praetorius ◽  
Karin Rohbock ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Auditory System ◽  
Critical Time ◽  
Organ Of Corti ◽  
Thyroid Gland Function ◽  
Distortion Product ◽  
Fetal Thyroid ◽  
Gland Function ◽  
Dependent Processes

Both a genetic or acquired neonatal thyroid hormone (TH) deficiency may result in a profound mental disability that is often accompanied by deafness. The existence of various TH-sensitive periods during inner ear development and general success of delayed, corrective TH treatment was investigated by treating pregnant and lactating rats with the goitrogen methimazole (MMI). We observed that for the establishment of normal hearing ability, maternal TH, before fetal thyroid gland function on estrus days 17–18, is obviously not required. Within a crucial time between the onset of fetal thyroid gland function and the onset of hearing at postnatal day 12 ( P12), any postponement in the rise of TH-plasma levels, as can be brought about by treating lactating mothers with MMI, leads to permanent hearing defects of the adult offspring. The severity of hearing defects that were measured in 3- to 9-mo-old offspring could be increased with each additional day of TH deficiency during this critical period. Unexpectedly, the active cochlear process, assayed by distortion product otoacoustic emissions (DPOAE) measurements, and speed of auditory brain stem responses, which both until now were not thought to be controlled by TH, proved to be TH-dependent processes that were damaged by a delay of TH supply within this critical time. In contrast, no significant differences in the gross morphology and innervation of the organ of Corti or myelin gene expression in the auditory system, detected as myelin basic protein (MBP) and proteolipid protein (PLP) mRNA using Northern blot approach, were observed when TH supply was delayed for few days. These classical TH-dependent processes, however, were damaged when TH supply was delayed for several weeks. These surprising results may suggest the existence of different TH-dependent processes in the auditory system: those that respond to corrective TH supply (e.g., innervation and morphogenesis of the organ of Corti) and those that do not, but require T3 activity during a very tight time window (e.g., active cochlear process, central processes).

Evaluation of Thyroid Gland Function in Children with Obstructive Apnea Hypopnea Syndrome

2011 ◽  
Vol 24 (2) ◽  
pp. 377-386 ◽  
Author(s):  
A.V. Sakellaropoulou ◽  
M.N. Hatzistilianou ◽  
M.N. Emporiadou ◽  
V.TH. Aivazis ◽  
I. Rousso ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Obstructive Apnea ◽  
Thyroid Gland Function ◽  
Gland Function ◽  
Hypopnea Syndrome

Temperature-humidity effects on thyroxin I131 disappearance rates in cattle

1963 ◽  
Vol 18 (1) ◽  
pp. 73-76 ◽  
Author(s):  
H. D. Johnson ◽  
H. H. Kibler
Keyword(s):  
Thyroid Gland ◽  
Feed Intake ◽  
Disappearance Rate ◽  
Peripheral Tissues ◽  
Humidity Effects ◽  
Thyroid Gland Function ◽  
Significant Depression ◽  
Humidity Index ◽  
Marked Decline ◽  
Gland Function

A significant depression of the thyroxin I131 disappearance rate was observed in lactating Holstein cows at 80 F, 80% relative humidity (RH); 85 F, 50% RH; 85 F, 70% RH; 90 F, 40% RH; 90 F, 50% RH; and 95 F, 20% RH. Differences from values at 65 F were not significant at 80 F, 30% RH; 80 F, 50% RH; 90 F, 20% RH; and 90 F, 25% RH. At 85 F and 90 F temperatures the effect of high humidity in depressing thyroxin I131 disappearance rate was obvious. Depression of hormone and feed intake at the higher humid temperatures suggests that the depression of thyroid gland function may be related to alteration in hormonal utilization in the peripheral tissues or to a more direct temperature effect (probably neural) on both thyroid gland secretion and appetite center. Thyroxin I131 disappearance rates, feed intake and body temperatures are expressed graphically relative to a temperature humidity index (THI) (U. S. Weather Bureau). The data show some decline above a THI of 71 and a marked decline above 75. Submitted on January 26, 1962

Thyroid Gland Function in Prepubertal and Pubertal Non-Ketotic Diabetic Children

1988 ◽  
Vol 30 (1) ◽  
pp. 94-95 ◽  
Author(s):  
Stefano Tumini ◽  
Francesco Chiarelli ◽  
Alberto Verrotti ◽  
Guido Morgese
Keyword(s):  
Thyroid Gland ◽  
Thyroid Gland Function ◽  
Diabetic Children ◽  
Gland Function

Is there any relation between thyroid gland function and kidney transplant function?

2003 ◽  
Vol 35 (6) ◽  
pp. 2222-2223 ◽  
Author(s):  
U Lebkowska ◽  
J Malyszko ◽  
W.J Lebkowski ◽  
J Walecki ◽  
M Mysliwiec
Keyword(s):  
Thyroid Gland ◽  
Kidney Transplant ◽  
Thyroid Gland Function ◽  
Transplant Function ◽  
Gland Function
Sign in / Sign up

Export Citation Format

Share Document