Correlation of in Vivo Relative Bioavailability to in Vitro Bioaccessibility for Arsenic in Household Dust from China and Its Implication for Human Exposure Assessment

2014 ◽  
Vol 48 (23) ◽  
pp. 13652-13659 ◽  
Author(s):  
Hong-Bo Li ◽  
Jie Li ◽  
Albert L. Juhasz ◽  
Lena Q. Ma
Keyword(s):  
Exposure Assessment ◽  
Human Exposure ◽  
Relative Bioavailability ◽  
Household Dust ◽  
In Vitro Bioaccessibility ◽  
Human Exposure Assessment

scholarly journals Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology

2009 ◽  
Vol 59 (1) ◽  
pp. 15-30 ◽  
Author(s):  
Pramod Kumar ◽  
Sanjay Singh ◽  
Brahmeshwar Mishra
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Relative Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Healthy Human ◽  
Tramadol Hydrochloride ◽  
Release Formulation ◽  
Extended Release Formulation

Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technologyExtended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional to the levels of plasticizer but inversely proportional to the levels of swellable polymer and coat thickness of SPM. Drug release from developed formulations was independent of pH and agitation intensity but dependent on osmotic pressure of the release media.In vivostudy was also performed on six healthy human volunteers and various pharmacokinetic parameters (cmax,tmax,AUC0-24,MRT) and relative bioavailability were calculated. Thein vitroandin vivoresults were compared with the performance of two commercial TRH tablets. The developed formulation provided more prolonged and controlled TRH release compared to the marketed formulation.In vitro-in vivocorrelation (IVIVC) was analyzed according to the Wagner-Nelson method. The optimized formulation (batch IVB) exhibited good IVIV correlation (R= 0.9750). The manufacturing procedure was found to be reproducible and formulations were stable over 6 months of accelerated stability testing.

Intra-urban variability of air pollution in Windsor, Ontario—Measurement and modeling for human exposure assessment

2008 ◽  
Vol 106 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Amanda J. Wheeler ◽  
Marc Smith-Doiron ◽  
Xiaohong Xu ◽  
Nicolas L. Gilbert ◽  
Jeffrey R. Brook
Keyword(s):  
Air Pollution ◽  
Exposure Assessment ◽  
Human Exposure ◽  
Human Exposure Assessment
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