Changes in the Expression ofcyp35a familyGenes in the Soil NematodeCaenorhabditis elegansunder Controlled Exposure to Chlorpyrifos Using Passive Dosing

2014 ◽  
Vol 48 (17) ◽  
pp. 10475-10481 ◽  
Author(s):  
Ji-Yeon Roh ◽  
Hwang Lee ◽  
Jung-Hwan Kwon
Keyword(s):  
Controlled Exposure ◽  
Passive Dosing

A Photoactivatable α5β1-Specific Integrin Ligand

2018 ◽  
Author(s):  
Roshna Vakkeel ◽  
Aleeza Farrukh ◽  
Aranzazu del Campo
Keyword(s):  
Cellular Response ◽  
Light Exposure ◽  
Matrix Composition ◽  
Cellular Behavior ◽  
Dynamic Variations ◽  
In Situ Activation ◽  
Controlled Exposure ◽  
Cellular Behaviour ◽  
Integrin Ligand

In order to study how dynamic changes of α5β1 integrin engagement affect cellular behaviour, photoactivatable derivatives of α5β1 specific ligands are presented in this article. The presence of the photoremovable protecting group (PRPG) introduced at a relevant position for integrin recognition, temporally inhibits ligand bioactivity. Light exposure at cell-compatible dose efficiently cleaves the PRPG and restores functionality. Selective cell response (attachment, spreading, migration) to the activated ligand on the surface is achieved upon controlled exposure. Spatial and temporal control of the cellular response is demonstrated, including the possibility to in situ activation. Photoactivatable integrin-selective ligands in model microenvironments will allow the study of cellular behavior in response to changes in the activation of individual integrins as consequence of dynamic variations of matrix composition.

scholarly journals Accelerated Passive Dosing of Hydrophobic Complex Mixtures–Controlling the Level and Composition in Aquatic Tests

2020 ◽  
Vol 54 (8) ◽  
pp. 4974-4983
Author(s):  
Rikke Hammershøj ◽  
Heidi Birch ◽  
Karina K Sjøholm ◽  
Philipp Mayer
Keyword(s):  
Complex Mixtures ◽  
Passive Dosing

Double blind placebo controlled exposure to molds: exposure system and clinical results*

Indoor Air ◽  
2005 ◽  
Vol 15 (s10) ◽  
pp. 73-80 ◽  
Author(s):  
H. W. Meyer ◽  
K. A. Jensen ◽  
K. F. Nielsen ◽  
J. Kildeso ◽  
S. Norn ◽  
...  
Keyword(s):  
Clinical Results ◽  
Double Blind ◽  
Exposure System ◽  
Double Blind Placebo ◽  
Controlled Exposure

Controlled exposure of female rhesus monkeys to 2,3,7,8-TCDD: Concentrations of TCDD in fat of offspring, and its decline over time

Chemosphere ◽  
1990 ◽  
Vol 20 (7-9) ◽  
pp. 1199-1202 ◽  
Author(s):  
R.E. Bowman ◽  
H.Y. Tong ◽  
M.L. Gross ◽  
S.J. Monson ◽  
N.C.A. Weerasinghe
Keyword(s):  
Rhesus Monkeys ◽  
Female Rhesus ◽  
Controlled Exposure ◽  
Over Time

The Potential of Video Game Streaming as Exposure Therapy for Social Anxiety

2021 ◽  
Vol 5 (CHI PLAY) ◽  
pp. 1-25
Author(s):  
Julian Frommel ◽  
Martin J. Dechant ◽  
Regan L. Mandryk
Keyword(s):  
Social Anxiety ◽  
Video Game ◽  
Exposure Therapy ◽  
Cognitive Restructuring ◽  
Social Situations ◽  
Socially Anxious ◽  
Controlled Exposure ◽  
Anxiety Treatment ◽  
Social Anxieties ◽  
And Performance

Social anxiety is a prevalent problem that affects many people with varying severity; digital exposure therapy-which involves controlled exposure to simulations of feared social situations alongside cognitive restructuring-can help treat patients with anxieties. However, the need to personalize exposure scenarios and simulate audiences are barriers to treating social anxieties through digital exposure. In this paper, we propose game streaming as an exposure therapy paradigm for social anxiety, supporting it with data from two studies. We first propose a framework describing requirements for exposure therapy and how game streaming can fulfill them. We select demand and performance visibility from these characteristics to showcase how to manipulate them for experiences of gradual exposure. With Study 1, we provide evidence for these characteristics and support for the framework by showing that a game's demand affected expected fear of streaming games. In Study 2, we show that the prospect of streaming led to elevated fear, a necessary property for effective exposure therapy. Further, we show that the effect of streaming on expected fear was similar for participants who can be considered socially anxious. These findings provide evidence for the essential effect of exposure therapy, which serves as a first step towards the validation of streaming as a social anxiety treatment. Our paper provides an initial, important step towards a novel, broadly applicable, and widely accessible digital approach for the treatment of social anxiety.

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