scholarly journals Tetrabromobisphenol A Disrupts Vertebrate Development via Thyroid Hormone Signaling Pathway in a Developmental Stage-Dependent Manner

2014 ◽  
Vol 48 (14) ◽  
pp. 8227-8234 ◽  
Author(s):  
Yin-Feng Zhang ◽  
Wei Xu ◽  
Qin-Qin Lou ◽  
Yuan-Yuan Li ◽  
Ya-Xian Zhao ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Developmental Stage ◽  
Signaling Pathway ◽  
Tetrabromobisphenol A ◽  
Dependent Manner ◽  
Hormone Signaling ◽  
Vertebrate Development

scholarly journals Liganded Thyroid Hormone Receptor Induces Nucleosome Removal and Histone Modifications to Activate Transcription during Larval Intestinal Cell Death and Adult Stem Cell Development

Endocrinology ◽  
2012 ◽  
Vol 153 (2) ◽  
pp. 961-972 ◽  
Author(s):  
Kazuo Matsuura ◽  
Kenta Fujimoto ◽  
Liezhen Fu ◽  
Yun-Bo Shi
Keyword(s):  
Cell Death ◽  
Gene Regulation ◽  
Thyroid Hormone ◽  
Chromatin Remodeling ◽  
Histone Modifications ◽  
Intestinal Cell ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Vertebrate Development

Thyroid hormone (T3) plays an important role in regulating multiple cellular and metabolic processes, including cell proliferation, cell death, and energy metabolism, in vertebrates. Dysregulation of T3 signaling results in developmental abnormalities, metabolic defects, and even cancer. We used T3-dependent Xenopus metamorphosis as a model to study how T3 regulates transcription during vertebrate development. T3 exerts its metamorphic effects through T3 receptors (TR). TR recruits, in a T3-dependent manner, cofactor complexes that can carry out chromatin remodeling/histone modifications. Whether and how histone modifications change upon gene regulation by TR during vertebrate development is largely unknown. Here we analyzed histone modifications at T3 target genes during intestinal metamorphosis, a process that involves essentially total apoptotic degeneration of the simple larval epithelium and de novo development of the adult epithelial stem cells, followed by their proliferation and differentiation into the complex adult epithelium. We demonstrated for the first time in vivo during vertebrate development that TR induces the removal of core histones at the promoter region and the recruitment of RNA polymerase. Furthermore, a number of histone activation and repression marks have been defined based on correlations with mRNA levels in cell cultures. Most but not all correlate with gene expression induced by liganded TR during development, suggesting that tissue and developmental context influences the roles of histone modifications in gene regulation. Our findings provide important mechanistic insights on how chromatin remodeling affects developmental gene regulation in vivo.

scholarly journals miR-130b Acts as an Oncogene and Prognostic Biomarker of Breast Cancer: A Bioinformatic Analysis

2020 ◽  
Author(s):  
Xinyue Chen ◽  
Lijun Hao
Keyword(s):  
Breast Cancer ◽  
Thyroid Hormone ◽  
Signaling Pathway ◽  
Target Genes ◽  
Kegg Pathway ◽  
Prognostic Biomarker ◽  
Pathway Enrichment Analysis ◽  
Hormone Signaling ◽  
Ppi Network ◽  
Hub Genes

Abstract Background: Breast cancer (BC) is the most prevalent cancer among females globally. microRNAs (miRNAs) could regulate the expression levels of cancer-related genes through binding with target mRNAs. In various cancers, the abnormal expression of miR-130b has been detected. We aims to investigate the molecular mechanism and biological function of miR130b in breast cancer.Methods: We obtained two microRNA expression profiles from the Gene Expression Omnibus (GEO) database, including GSE45666 and GSE26659. We identified differentially expressed miRNAs (DE-miRNAs) between BC tissue and normal breast tissue based on the GEO2R web tool. DE-miRNAs were filtered by significant prognostic value resulting from Kaplan–Meier plotter. We used the JASPAR database to explore upstream regulators of miR-130b. The potential molecular mechanisms of miR-130b correlation genes were revealed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis in WebGestalt. Protein–protein interaction (PPI) network of miR-130b target genes was constructed by STRING. Cytoscape software was used to visualize the PPI network and hub genes.Results: miR-130b was highly expressed in breast cancer tissues, which positively correlates with poor prognostic. JASPAR revealed THAP11 might be the upstream regulator of miR-130b. In addition, GO, and KEGG pathway revealed that miR-130b positively regulated PFKP, STAT1, SRC, and NOTCH2, participating in the Thyroid hormone signaling pathway. The PPI network further identified that AR, KIT, and ESR1 as hub genes in BC development.Conclusion: miR-130b, which is regulated by THAP11, acts as an oncogene and prognostic biomarker in BC by mediating the Thyroid hormone signaling pathway and potential target genes. miR-130b might be a novel therapeutic target for BC treatment.

Effects of nitrate on development and thyroid hormone signaling pathway during Bufo gargarizans embryogenesis

Chemosphere ◽  
2019 ◽  
Vol 235 ◽  
pp. 227-238 ◽  
Author(s):  
Lei Xie ◽  
Yuhui Zhang ◽  
Yanhua Qu ◽  
Lihong Chai ◽  
Xinyi Li ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathway ◽  
Hormone Signaling ◽  
Bufo Gargarizans

Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo

2018 ◽  
Vol 237 ◽  
pp. 1072-1079 ◽  
Author(s):  
Yin-Feng Zhang ◽  
Xiao-Min Ren ◽  
Yuan-Yuan Li ◽  
Xiao-Fang Yao ◽  
Chuan-Hai Li ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Hormone Signaling ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Vitamin A Affects Flatfish Development in a Thyroid Hormone Signaling and Metamorphic Stage Dependent Manner

2017 ◽  
Vol 8 ◽  
Author(s):  
Ignacio Fernández ◽  
Juan B. Ortiz-Delgado ◽  
Maria J. Darias ◽  
Francisco Hontoria ◽  
Karl B. Andree ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Vitamin A ◽  
Dependent Manner ◽  
Hormone Signaling ◽  
Metamorphic Stage

The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway

2008 ◽  
Vol 218 (11-12) ◽  
pp. 667-680 ◽  
Author(s):  
Mathilde Paris ◽  
Frédéric Brunet ◽  
Gabriel V. Markov ◽  
Michael Schubert ◽  
Vincent Laudet
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathway ◽  
Hormone Signaling ◽  
Amphioxus Genome

scholarly journals Adaptive Divergence in the Thyroid Hormone Signaling Pathway in the Stickleback Radiation

2010 ◽  
Vol 20 (23) ◽  
pp. 2124-2130 ◽  
Author(s):  
Jun Kitano ◽  
Sean C. Lema ◽  
J. Adam Luckenbach ◽  
Seiichi Mori ◽  
Yui Kawagishi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Signaling Pathway ◽  
Adaptive Divergence ◽  
Hormone Signaling
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