In Situ Formation of Pyromorphite Is Not Required for the Reduction of in Vivo Pb Relative Bioavailability in Contaminated Soils

2014 ◽  
Vol 48 (12) ◽  
pp. 7002-7009 ◽  
Author(s):  
Albert L. Juhasz ◽  
Dorota Gancarz ◽  
Carina Herde ◽  
Stuart McClure ◽  
Kirk G. Scheckel ◽  
...  
Keyword(s):  
Contaminated Soils ◽  
Relative Bioavailability ◽  
In Situ Formation

In situ formation of bioactive calcium titanate coatings on titanium screws for medical implants

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53182-53187 ◽  
Author(s):  
Yinhui Zhu ◽  
Xiaokang Wang ◽  
Yilong Zhou ◽  
Cuilian Zhao ◽  
Jianmin Yuan ◽  
...  
Keyword(s):  
Hydrothermal Method ◽  
Calcium Titanate ◽  
Medical Implants ◽  
Facile Hydrothermal Method ◽  
Titanium Screws ◽  
Special Morphology ◽  
In Situ Formation

The special morphology of CaTiO3 coatings synthesized by a facile hydrothermal method improved titanium's in vitro and in vivo biocompatibility.

scholarly journals Bioavailable soil Pb minimized by in situ transformation to plumbojarosite

2020 ◽  
pp. 202020315
Author(s):  
Ranju R. Karna ◽  
Matt R. Noerpel ◽  
Clay Nelson ◽  
Brittany Elek ◽  
Karen Herbin-Davis ◽  
...  
Keyword(s):  
Contaminated Soils ◽  
Relative Bioavailability ◽  
Physiochemical Properties ◽  
Adverse Health Effects ◽  
Pb Contamination ◽  
Major Route ◽  
Pb Exposure ◽  
X Ray Absorption ◽  
Properties Of Soil

Exposure to lead (Pb) during early life has persistent adverse health effects. During childhood, ingestion of bioavailable Pb in contaminated soils can be a major route of Pb absorption. Remediation to alter physiochemical properties of soil-borne Pb can reduce Pb bioavailability. Our laboratory-based approach for soil Pb remediation uses addition of iron (Fe) sulfate and application of heat to promote formation of plumbojarosite (PLJ), a sparingly soluble Pb-Fe hydroxysulfate mineral. We treated two soils with anthropogenic Pb contamination and samples of clean topsoil spiked with various Pb compounds (i.e., carbonate, chloride, phosphate [P], or sulfate) to convert native Pb species to PLJ and used a mouse assay to assess relative bioavailability (RBA) of Pb in untreated (U) and remediated soils. Bone and blood Pb levels were significantly lower (P< 0.001, Student'sttest) in mice that consumed diets amended with remediated soils than with U soils. Estimated RBA for Pb in both remediated natural soils and Pb-mineral spiked soils were reduced by >90% relative to Pb RBA for U soils, which is substantially more effective than other soil amendments, including P. X-ray absorption spectroscopy showed that >90% of all Pb species in remediated soils were converted to PLJ, and ingested PLJ was not chemically transformed during gastrointestinal tract transit. Post treatment neutralization of soil pH did not affect PLJ stability, indicating the feasibility in field conditions. These results suggest that formation of PLJ in contaminated soils can reduce the RBA of Pb and minimize this medium’s role as a source of Pb exposure for young children.

scholarly journals ABSOLUTE AND RELATIVE BIOAVAILABILITY STUDY FOR THE NEWLY DEVELOPED NASAL NANOEMULSION IN SITU GEL OF ONDANSETRON HCl IN COMPARISON TO CONVENTIONALLY PREPARED IN SITU GEL AND INTRAVENOUS DOSAGES FORMS

2018 ◽  
Vol 10 (5) ◽  
pp. 105
Author(s):  
Nidhal K. Maraie ◽  
Yasser Q. Almajidi ◽  
Ahmed Alshadher
Keyword(s):  
Relative Bioavailability ◽  
The Body ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Studies ◽  
Bioavailability Enhancement ◽  
In Situ Gel ◽  
Bioavailability Study ◽  
The Absolute

Objective: The aim of the work was to study the absolute and relative bioavailability (using rabbits) of ondansetron HCl (ONH)from our newly prepared intranasal mucoadhesive nanoemulsion in situ gel (NIG) in comparison to intranasal mucoadhesive in situ gel (IG) prepared by the conventional method and intravenous injection.Methods: Six male rabbits weighing 2.5-3 kg were used in this study, where the dose of ondansetron HCl (ONH) was calculated based on the body surface area (BSA) which is equivalent to 140μl (containing 10 mg/ml) of NIG and IG and 700μl of intravenous Zofran® injection (containing 2 mg/ml) were given to the rabbits, separated with one week washout period. Serial blood samples were withdrawn and analyzed for simultaneous determination of the drug using HPLC (Knaure; 150 ×4.6 mm; 5 μm particle size; 25 cm length) supported by guard column C18-4 mm diameter.Results: The pharmacokinetics parameters for NIG; Cmax, Tmax, AUC0-t, AUC0-∞were found to be greater than conventional in situ gel (IG). In vivo pharmacokinetic studies in rabbits showed a significant increase in Cmax and AUC 0-α(P<0.001) with shorter Tmaxusing NIG compared to IG containing the same NIG excipients, while the absolute bioavailability for NIG and IG (was 80.541 and 51.068 respectively).Conclusion: The present studies ratify the bioavailability enhancement potential of NE used to prepare NIG for the drug and significantly high absolute bioavailability to be used as a successful alternative route to the IV injection and improve patient compliance.

scholarly journals Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride

2020 ◽  
Vol 70 (3) ◽  
pp. 411-422 ◽  
Author(s):  
Fugen Gu ◽  
Huimin Fan ◽  
Zhixin Cong ◽  
Shuang Li ◽  
Yi Wang ◽  
...  
Keyword(s):  
Ph Value ◽  
Relative Bioavailability ◽  
Nasal Delivery ◽  
Poloxamer 407 ◽  
Nasal Administration ◽  
Pharmacokinetic Parameters ◽  
Donepezil Hydrochloride

AbstractDonepezil hydrochloride thermosensitive in situ gel for nasal delivery was prepared by using Poloxamer 407 and Poloxamer 188 as thermoreversible polymers, hydroxypropyl-β-cyclodextrin and ethylparaben as permeation enhancer and preservative, respectively. The gelation temperature and time, pH value of the gel formulation were found to meet the requirements for nasal administration. The in vitro erosion and in vitro release tests exhibited obvious drug sustained release behavior. Meantime, main pharmacokinetic parameters such as tmax, cmax and AUC in plasma as well as in brain were significantly different between the nasal gel formulation and intragastric drug solution in rats (p < 0.01). The relative bioavailability and drug targeting efficiency of the gel formulation were calculated to be 385.6 and 151.2 %, respectively. Thus, the drug gel formulation might be a potential new delivery system for treatment of Alzheimer’s disease due to its higher bioavailability and better distribution to brain when compared to oral route.

In situ formation of biphasic calcium phosphates and their biological performance in vivo

2012 ◽  
Vol 38 (3) ◽  
pp. 1965-1974 ◽  
Author(s):  
Tae-Wan Kim ◽  
Young Min Park ◽  
Dong-Hyun Kim ◽  
Hyeong-Ho Jin ◽  
Keun-Koo Shin ◽  
...  
Keyword(s):  
Calcium Phosphates ◽  
In Situ Formation ◽  
Biological Performance

Development of a dual drug-loaded hydrogel delivery system for enhanced cancer therapy: in situ formation, degradation and synergistic antitumor efficiency

2017 ◽  
Vol 5 (43) ◽  
pp. 8487-8497 ◽  
Author(s):  
Cui Cheng ◽  
Xiuli Zhang ◽  
Yabin Meng ◽  
Li Chen ◽  
Qiqing Zhang
Keyword(s):  
Drug Therapy ◽  
Cancer Therapy ◽  
Delivery System ◽  
Combination Drug Therapy ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
In Situ Formation ◽  
Dual Drug

A stimuli-responsive, biodegradable, and dual drug-loaded hydrogel delivery system was formed in situ for combination drug therapy of cancer in vivo.

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