Role of Tetracycline Speciation in the Bioavailability to Escherichia coli for Uptake and Expression of Antibiotic Resistance

2014 ◽  
Vol 48 (9) ◽  
pp. 4893-4900 ◽  
Author(s):  
Yingjie Zhang ◽  
Stephen A. Boyd ◽  
Brian J. Teppen ◽  
James M. Tiedje ◽  
Hui Li
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance

Role of enterotoxigenic Escherichia coli prophage in spreading antibiotic resistance in a porcine‐derived environment

2020 ◽  
Vol 22 (12) ◽  
pp. 4974-4984 ◽  
Author(s):  
Mianzhi Wang ◽  
Zhenling Zeng ◽  
Fengwei Jiang ◽  
Ying Zheng ◽  
Huigang Shen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Enterotoxigenic Escherichia Coli

scholarly journals Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

2018 ◽  
Author(s):  
Ji Lu ◽  
Min Jin ◽  
Son Hoang Nguyen ◽  
Likai Mao ◽  
Jie Li ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Potential Role ◽  
Efflux Pump ◽  
Genetic Mutation ◽  
Multi Drug Resistance ◽  
Key Factors ◽  
Genes Encoding ◽  
Drug Efflux Pump

ABSTRACTAntibiotic resistance poses a major threat to public health. Overuse and misuse of antibiotics are generally recognised as the key factors contributing to antibiotic resistance. However, whether non-antibiotic, anti-microbial (NAAM) chemicals can directly induce antibiotic resistance is unclear. We aim to investigate whether the exposure to a NAAM chemical triclosan (TCS) has an impact on inducing antibiotic resistance on Escherichia coli. Here, we report that at a concentration of 0.2 mg/L TCS induces multi-drug resistance in wild-type Escherichia coli after 30-day TCS exposure. The oxidative stress induced by TCS caused genetic mutations in genes such as fabI, frdD, marR, acrR and soxR, and subsequent up-regulation of the transcription of genes encoding beta-lactamase and multi-drug efflux pump, together with down-regulation of genes related to membrane permeability. The findings advance our understanding of the potential role of NAAM chemicals in the dissemination of antibiotic resistance in microbes, and highlights the need for controlling biocide applications.

scholarly journals EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity

2020 ◽  
Vol 24 ◽  
pp. 18-24 ◽  
Author(s):  
Michael R. Padgen ◽  
Matthew P. Lera ◽  
Macarena P. Parra ◽  
Antonio J. Ricco ◽  
Matthew Chin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Stationary Phase

scholarly journals Escherichia coli Population Structure and Antibiotic Resistance at a Buffalo/Cattle Interface in Southern Africa

2015 ◽  
Vol 82 (5) ◽  
pp. 1459-1467 ◽  
Author(s):  
Mathilde Mercat ◽  
Olivier Clermont ◽  
Méril Massot ◽  
Etienne Ruppe ◽  
Michel de Garine-Wichatitsky ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Genetic Material ◽  
Pathogen Transmission ◽  
African Buffalo ◽  
Content Type ◽  
E Coli ◽  
Natural Interface ◽  
Contact Patterns

ABSTRACTAt a human/livestock/wildlife interface,Escherichia colipopulations were used to assess the risk of bacterial and antibiotic resistance dissemination between hosts. We used phenotypic and genotypic characterization techniques to describe the structure and the level of antibiotic resistance ofE. colicommensal populations and the resistantEnterobacteriaceaecarriage of sympatric African buffalo (Syncerus caffer caffer) and cattle populations characterized by their contact patterns in the southern part of Hwange ecosystem in Zimbabwe. Our results (i) confirmed our assumption that buffalo and cattle share similar phylogroup profiles, dominated by B1 (44.5%) and E (29.0%) phylogroups, with some variability in A phylogroup presence (from 1.9 to 12%); (ii) identified a significant gradient of antibiotic resistance from isolated buffalo to buffalo in contact with cattle and cattle populations expressed as the Murray score amongEnterobacteriaceae(0.146, 0.258, and 0.340, respectively) and as the presence of tetracycline-, trimethoprim-, and amoxicillin-resistant subdominantE. colistrains (0, 5.7, and 38%, respectively); (iii) evidenced the dissemination of tetracycline, trimethoprim, and amoxicillin resistance genes (tet,dfrA, andblaTEM-1) in 26 isolated subdominantE. colistrains between nearby buffalo and cattle populations, that led us (iv) to hypothesize the role of the human/animal interface in the dissemination of genetic material from human to cattle and toward wildlife. The study of antibiotic resistance dissemination in multihost systems and at anthropized/natural interface is necessary to better understand and mitigate its multiple threats. These results also contribute to attempts aiming at usingE. colias a tool for the identification of pathogen transmission pathway in multihost systems.

scholarly journals Role of Pseudomonas aeruginosa Biofilm in the Development of Antibiotic Resistance in Escherichia coli

2018 ◽  
Vol 7 (2) ◽  
pp. 40-46
Author(s):  
Jillian Pia Raquid ◽  
John Carlo Prieto ◽  
Danica Mae Arciaga ◽  
Rica Hazel Corpuz ◽  
Shally Mae Llorente ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance
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