Differential Effects and Potential Adverse Outcomes of Ionic Silver and Silver Nanoparticles in Vivo and in Vitro

2014 ◽  
Vol 48 (8) ◽  
pp. 4546-4555 ◽  
Author(s):  
Natàlia Garcia-Reyero ◽  
Alan J. Kennedy ◽  
B. Lynn Escalon ◽  
Tanwir Habib ◽  
Jennifer G. Laird ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Adverse Outcomes ◽  
Differential Effects ◽  
Ionic Silver

In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses

Toxicology ◽  
2016 ◽  
Vol 355-356 ◽  
pp. 1-8 ◽  
Author(s):  
Jenna D. Strickland ◽  
William R. LeFew ◽  
James Crooks ◽  
Diana Hall ◽  
Jayna N.R. Ortenzio ◽  
...  
Keyword(s):  
Neural Networks ◽  
Silver Nanoparticles ◽  
Spontaneous Activity ◽  
In Vitro Screening ◽  
Differential Effects ◽  
Ionic Silver

scholarly journals Silver Nanoparticles and Their Antibacterial Applications

2021 ◽  
Vol 22 (13) ◽  
pp. 7202
Author(s):  
Tamara Bruna ◽  
Francisca Maldonado-Bravo ◽  
Paul Jara ◽  
Nelson Caro
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Agents ◽  
Multidrug Resistant ◽  
Secondary Effects ◽  
Cytotoxic Effects ◽  
Factors Affecting ◽  
Gram Positive Bacteria ◽  
Resistant Strains

Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.

scholarly journals Differential effects of doxorubicin on atrial natriuretic peptide expression in vivo and in vitro

2001 ◽  
Vol 34 (3-4) ◽  
Author(s):  
ASIM RAHMAN ◽  
MAHMOOD ALAM ◽  
SUDHA RAO ◽  
LIN CAI ◽  
CLARK LUTHER T. ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Differential Effects ◽  
Peptide Expression ◽  
Atrial Natriuretic

scholarly journals Incorporation of silver nanoparticles on Ti7.5Mo alloy surface containing TiO2 nanotubes arrays for promoting antibacterial coating – In vitro and in vivo study

2018 ◽  
Vol 455 ◽  
pp. 780-788 ◽  
Author(s):  
Ana Paula Rosifini Alves Claro ◽  
Reginaldo T. Konatu ◽  
Ana Lúcia do Amaral Escada ◽  
Miriam Celi de Souza Nunes ◽  
Cláudia Vianna Maurer-Morelli ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Tio2 Nanotubes ◽  
In Vivo Study ◽  
Alloy Surface ◽  
Antibacterial Coating

Unravelling the role of surface modification in the dermocompatibility of silver nanoparticles in vitro and in vivo

Chemosphere ◽  
2021 ◽  
pp. 133111
Author(s):  
Ziyi Xiong ◽  
Lei Liu ◽  
Zhaolun Zhang ◽  
Lihua Cao ◽  
Ding Cao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Surface Modification

Silver nanoparticles used to counter Monilinia fructicola fungicide-resistance and reduce fungicide environmental footprint 

2021 ◽  
Author(s):  
Constantinos Chrysikopoulos ◽  
Anastasios A. Malandrakis ◽  
Nektarios Kavroulakis ◽  
Anthi Stefanarou
Keyword(s):  
Silver Nanoparticles ◽  
Control Plant ◽  
Resistance Mutation ◽  
Silver Ions ◽  
Apple Fruit ◽  
Ag Nps ◽  
Gene Target ◽  
Benzimidazole Fungicides

<div><span>The potential of silver nanoparticles (Ag-NPs) to control plant pathogen <em>Monilia</em><em>fructicola </em>and to deter environmental contamination by reducing fungicide doses was evaluated <em>in vitro </em>and <em>in vivo. </em> </span>F<span>ungitoxicity screening </span>of <em><span>M. fructicola </span></em><span>isolates resulted in the detection of 18 benzimidazole-resistant (BEN-R) isolates with reduced sensitivity to fungicides  thiophanate methyl (TM)  and carbendazim. All resistant isolates caried the E198A resistance mutation in their </span><em><span>β</span>-</em>tubulin gene, target site of the benzimidazole fungicides. <span>Ag-NPs could effectively control both sensitive (BEN-S) and resistant isolates while the combination of Ag-NPs with TM significantly enhanced their fungitoxic effect both <em>in vitro </em>and in apple fruit tests. The positive correlation observed between Ag-NPs and TM+Ag-NPs treatments indicates a mixture-enhanced Ag-NPs activity/availability as a possible mechanism of synergy. No correlation between Ag-NPs  and AgNO<sub>3 </sub>could  be found suggesting difference(s) in the fungitoxic mechanism of action between Nps and their bulk/ionic counterparts. Indications of the involvement of energy (ATP) metabolism in the mode of action of Ag-NPs were also evident by the synergy observed between Ag-NPs and the </span>oxidative phosphorylation<span>-uncoupler fluazinam (FM) against both BEN-R and BEN-S phenotypes. The role of silver ions release on the inhibitory action of Ag-NPs against the fungusis probably limited since the AgNPs/NaCl combination enhanced fungitoxicity, a fact that could not be justified by the expected binding of silver with chlorine ions. Concluding, Ag-NPs can be effectively used as a means of controlling both BEN-S and BEN-R <em>M. </em><em>fructicola </em>isolates </span>while <span>their combination with conventional fungicides should aid anti-resistant strategies and reduce the environmental impact of synthetic fungicides by reducing effective doses to the control the pathogen.</span></div>

In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles

2016 ◽  
pp. 1554-1567
Author(s):  
Meghan E. Samberg ◽  
Zhoumeng Lin ◽  
Nancy A. Monteiro-Riviere
Keyword(s):  
Silver Nanoparticles ◽  
In Vivo Toxicity

scholarly journals Species-Specific in vitro and in vivo Evaluation of Toxicity of Silver Nanoparticles Stabilized with Gum Arabic Protein

2020 ◽  
Vol Volume 15 ◽  
pp. 7359-7376
Author(s):  
Joana S Maziero ◽  
Velaphi C Thipe ◽  
Sizue O Rogero ◽  
Adriana K Cavalcante ◽  
Kelme C Damasceno ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gum Arabic ◽  
In Vivo Evaluation ◽  
Species Specific
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