Urinary Metabolic Biomarkers Link Oxidative Stress Indicators Associated with General Arsenic Exposure to Male Infertility In a Han Chinese Population

2013 ◽  
pp. 130722083038001 ◽  
Author(s):  
Heqing Shen ◽  
Weipan Xu ◽  
Jie Zhang ◽  
Minjian Chen ◽  
Francis L Martin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Chinese Population ◽  
Arsenic Exposure ◽  
Han Chinese ◽  
Stress Indicators ◽  
Han Chinese Population ◽  
Metabolic Biomarkers ◽  
Oxidative Stress Indicators

Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population

2010 ◽  
Vol 25 (7) ◽  
pp. 1657-1665 ◽  
Author(s):  
X. Ding ◽  
J. Zhang ◽  
J. Fei ◽  
Z. Bian ◽  
Y. Li ◽  
...  
Keyword(s):  
Male Infertility ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Idiopathic Male Infertility

scholarly journals Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 45242-45248 ◽  
Author(s):  
Lianjun Pan ◽  
Qingzhen Liu ◽  
Jingyun Li ◽  
Wei Wu ◽  
Xinru Wang ◽  
...  
Keyword(s):  
Male Infertility ◽  
Gene Polymorphism ◽  
Chinese Population ◽  
Sperm Count ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Idiopathic Male Infertility

scholarly journals A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese population

2007 ◽  
Vol 22 (4) ◽  
pp. 1107-1113 ◽  
Author(s):  
B. Wu ◽  
N.X. Lu ◽  
Y.K. Xia ◽  
A.H. Gu ◽  
C.C. Lu ◽  
...  
Keyword(s):  
Male Infertility ◽  
Y Chromosome ◽  
Chinese Population ◽  
Strong Association ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Xia ◽  
Chunyue Guo ◽  
Kuo Liu ◽  
Yunyi Xie ◽  
Han Cao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Chinese Population ◽  
Left Ventricular Mass Index ◽  
Mendelian Randomization ◽  
Left Ventricular ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Internal Dimension

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

scholarly journals Fluctuation of oxidative stress indicators in Salix nigra seeds during priming

2012 ◽  
Vol 63 (10) ◽  
pp. 3631-3642 ◽  
Author(s):  
G. Roqueiro ◽  
S. Maldonado ◽  
M. d. C. Rios ◽  
H. Maroder
Keyword(s):  
Oxidative Stress ◽  
Salix Nigra ◽  
Stress Indicators ◽  
Oxidative Stress Indicators

Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population

2020 ◽  
Vol 23 (8) ◽  
pp. 1050-1056
Author(s):  
Tianyun Zhao ◽  
Chi Ma ◽  
Wei Wang ◽  
Bin Zhao ◽  
Baopin Xie ◽  
...  
Keyword(s):  
Chinese Population ◽  
Hip Osteoarthritis ◽  
Han Chinese ◽  
Common Variants ◽  
Han Chinese Population

scholarly journals Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanmei Ruan ◽  
Jinwei Zhang ◽  
Shiqi Mai ◽  
Wenfeng Zeng ◽  
Lili Huang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chinese Population ◽  
Conditional Logistic Regression ◽  
Han Chinese ◽  
Control Group ◽  
Environment Interaction ◽  
Noise Induced Hearing Loss ◽  
Han Chinese Population ◽  
Hearing Thresholds ◽  
Increased Risk

AbstractGenetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.

Sign in / Sign up

Export Citation Format

Share Document