scholarly journals Temporal Trends of Polybrominated Diphenyl Ethers (PBDEs) in the Blood of Newborns from New York State during 1997 through 2011: Analysis of Dried Blood Spots from the Newborn Screening Program

2013 ◽  
Vol 47 (14) ◽  
pp. 8015-8021 ◽  
Author(s):  
Wan-Li Ma ◽  
Sehun Yun ◽  
Erin M. Bell ◽  
Charlotte M. Druschel ◽  
Michele Caggana ◽  
...  
Keyword(s):  
New York ◽  
Newborn Screening ◽  
Polybrominated Diphenyl Ethers ◽  
Screening Program ◽  
New York State ◽  
Temporal Trends ◽  
Dried Blood Spots ◽  
Newborn Screening Program ◽  
York State ◽  
Diphenyl Ethers

Use of Newborn Screening Program Blood Spots for Exposure Assessment: Declining Levels of Perfluorinated Compounds in New York State Infants

2008 ◽  
Vol 42 (14) ◽  
pp. 5361-5367 ◽  
Author(s):  
Henry M. Spliethoff ◽  
Lin Tao ◽  
Shannon M. Shaver ◽  
Kenneth M. Aldous ◽  
Kenneth A. Pass ◽  
...  
Keyword(s):  
New York ◽  
Newborn Screening ◽  
Exposure Assessment ◽  
Screening Program ◽  
New York State ◽  
Perfluorinated Compounds ◽  
Newborn Screening Program ◽  
York State ◽  
Blood Spots

α-Fetoprotein and Hypothyroidism in Infants

PEDIATRICS ◽  
1992 ◽  
Vol 90 (6) ◽  
pp. 1008-1009
Author(s):  
G. J. MIZEJEWSKI ◽  
K. A. PASS
Keyword(s):  
New York ◽  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Screening Program ◽  
New York State ◽  
Elevated Serum ◽  
Thyroid Stimulating Hormone ◽  
Newborn Screening Program ◽  
Newborn Period ◽  
York State

To the Editor.— We recently have documented a relationship between serum α-fetoprotein (AFP) and congenital hypothyroidism (CH) in the newborn period. Previous studies in our laboratory and others had reported a relationship between elevated serum AFP and elevated thyroid-stimulating hormone (TSH)/low thyroxine T4 in newborns and infants in the first few months of life.1-4 The New York State Newborn Screening Program for CH routinely screens more than 300 000 specimens per year diagnosing 120 to 140 confirmed cases of CH annually.

Cellulose Acetate/Citrate Agar Electrophoresis of Filter Paper Hemolysates From Heel Stick

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 839-842
Author(s):  
Lewis M. Schedlbauer ◽  
Kenneth A. Pass
Keyword(s):  
New York ◽  
Newborn Screening ◽  
Cellulose Acetate ◽  
Filter Paper ◽  
Screening Program ◽  
New York State ◽  
Medical Personnel ◽  
Health Department ◽  
York State ◽  
Set Up

In 1965, New York State Public Health Law 2500-a was enacted, mandating the screening of all newborns for phenylketonuria. The law was amended in 1974 to include testing for six other conditions, one of which is homozygous sickle cell disease. Originally, all screening was done in four semiautonomous laboratories located in Erie County (Buffalo), Onondaga County (Syracuse), New York City, and Albany County (Albany). These laboratories were set up to receive, test, and report results of all specimens in their respective regions of the state. Between 1981 and 1985, all screening was centralized at the Wadsworth Laboratories of the New York State Health Department in Albany, where in 1986 the newborn screening laboratory tested more than 288,000 specimens. Hemoglobin is screened with the two-tier procedure of Garrick et al: alkaline electrophoresis on cellulose acetate followed by acid electrophoresis on citrate agar. METHODS/PROCEDURES The average daily volume of the New York State Newborn Screening Program is 1,200 specimens, but the number of specimens can range from 800 to 3,000 per day. Specimens are collected from infant blood obtained by heel stick on Schleicher and Schuell 903 filter paper. Medical personnel are advised to collect the specimen when the infant is three to five days of age and before any planned transfusion is administered. The specimens are air dried and mailed to the laboratory within 24 hours of collection. When received in the laboratory accessioning unit, the specimens are examined to determine their suitability for testing. Specimens are screened for sickle hemoglobin only if there is sufficient blood on the filter paper and the date of collection to date of laboratory receipt is less than 14 day.

scholarly journals Gender disparities in screening for congenital hypothyroidism using thyroxine as a primary screen

2018 ◽  
Vol 179 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Lenore DeMartino ◽  
Rebecca McMahon ◽  
Michele Caggana ◽  
Norma P Tavakoli
Keyword(s):  
New York ◽  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Screening Program ◽  
New York State ◽  
Dried Blood Spots ◽  
Thyroid Stimulating Hormone ◽  
Specimen Collection ◽  
The Mean ◽  
Infant Birth

Objective Newborn screening for congenital hypothyroidism (CH) is based on testing for the markers thyroxine (T4) and/or thyroid-stimulating hormone (TSH). Diagnosis of CH is complicated because many factors affect the levels of these hormones including infant birth weight, prematurity and age at specimen collection. We investigated whether the sex of the newborn affected the levels of T4 and TSH and consequently the outcome of newborn screening. Design In New York State, the Newborn Screening program initially tests all infants for T4 and any baby with a result in the lowest 10% is triaged for TSH screening. We analyzed data from 2008 to 2016 to determine mean and median T4 and TSH values and how these results correlate with the sex of infants who are reported as borderline, referred and confirmed with CH. Methods T4 and TSH concentrations in dried blood spots were measured using commercially available fluoroimmunoassays. Results From 2008 to 2016, of the 2.4 million specimens tested for thyroxine, 51.5% were from male and 48.5% were from female infants. Male infants constituted 60% of specimens triaged for TSH testing, 64.9% of repeat requests and 59.6% of referrals, but only 49% of confirmed CH cases. The mean and median T4 values were lower (a difference of approximately 0.8–1.1 μg/dL each year) and the median TSH values were higher in male compared to female infants. Conclusions Natural differences in thyroid hormone levels in male and female infants leads to male infants being disproportionately represented in the false-positive category.

scholarly journals A large-scale retrospective study of opioid poisoning in New York State with implications for targeted interventions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xin Chen ◽  
Wei Hou ◽  
Sina Rashidian ◽  
Yu Wang ◽  
Xia Zhao ◽  
...  
Keyword(s):  
New York ◽  
Race And Ethnicity ◽  
Large Scale ◽  
New York State ◽  
Temporal Trends ◽  
Opioid Overdose ◽  
York State ◽  
Targeted Interventions ◽  
Level Data ◽  
Zip Code

AbstractOpioid overdose related deaths have increased dramatically in recent years. Combating the opioid epidemic requires better understanding of the epidemiology of opioid poisoning (OP). To discover trends and patterns of opioid poisoning and the demographic and regional disparities, we analyzed large scale patient visits data in New York State (NYS). Demographic, spatial, temporal and correlation analyses were performed for all OP patients extracted from the claims data in the New York Statewide Planning and Research Cooperative System (SPARCS) from 2010 to 2016, along with Decennial US Census and American Community Survey zip code level data. 58,481 patients with at least one OP diagnosis and a valid NYS zip code address were included. Main outcome and measures include OP patient counts and rates per 100,000 population, patient level factors (gender, age, race and ethnicity, residential zip code), and zip code level social demographic factors. The results showed that the OP rate increased by 364.6%, and by 741.5% for the age group > 65 years. There were wide disparities among groups by race and ethnicity on rates and age distributions of OP. Heroin and non-heroin based OP rates demonstrated distinct temporal trends as well as major geospatial variation. The findings highlighted strong demographic disparity of OP patients, evolving patterns and substantial geospatial variation.

Abstract 12259: Epidemiology of Valvular Heart Diseases: A 30-Year Retrospective of Hospitalizations and In-Hospital Mortality in New York State

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Phyllis G Supino ◽  
Ofek Y Hai ◽  
Nasimullah Khan ◽  
Jeffrey S Borer
Keyword(s):  
New York ◽  
Heart Diseases ◽  
New York State ◽  
Temporal Trends ◽  
Case Fatality ◽  
Female Gender ◽  
York State ◽  
Death Risk ◽  
Valvular Heart Diseases ◽  
Rate Of Increase

Background: Valvular heart disease (VHD) is among the most predictable causes of heart failure (HF) and an important cause of sudden death. Temporal trends of clinically significant VHD during the past three decades have not been defined. Methods: To obtain information for our region, we conducted a longitudinal analysis of all inpatient hospital records (79,689,879) obtained from the New York State (NYS) Statewide Planning and Research Cooperative System (SPARCS) database for years 1983 (first year reliable data were consistently available) through 2012 (last year data were complete). VHD cases (2,720,313) were identified from principal or secondary ICD-9 codes for aortic, mitral, tricuspid or pulmonic VHD. Linear regression was used to evaluate trends over time for VHD hospitalizations, valve surgery (VS) and in-hospital deaths. Logistic regression was used to predict mortality risk factors. Results: From 1983-2012, total hospitalizations decreased by ~500,000 cases; simultaneously, VHD hospitalizations increased markedly (34,395 in 1983 to 125,139 in 2012). Rate of increase was linear across all VHD categories = 4,248 new cases (12.4%)/yr, r 2 = 0.99, p<.0001) through 2006 (peak= 132,323 cases), and then flattened through 2012. A parallel trend was found for VS, though no appreciable flattening occurred (2,582 cases in 1983 to 7,787 in 2012, linearized increase rate=207 VS [8.0%]/yr, r 2 =0.97, p<.001). Both numbers of hospitalizations and performance of VS rose with patient age (p<.001). Over the study interval, 123,787 patients with VHD died in the hospital, including 9,272 who died after VS; avg case fatality rates were 4.6% (all VHD) and 6.4% (VS). Deaths were independently associated with advancing age, nonelective admission and presence of associated HF (p<.0001, all). Male gender predicted increased death risk among the general VHD population; female gender predicted death risk among those undergoing VS. Conclusions: The incidence of VHD hospitalization and VS in NYS has risen substantially since the early 1980s and can be expected to rise further as the population ages. Thus, intensive planning is needed to deal with public health implications of these trends as we attempt to meet the growing needs of this patient population.

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