X-ray Absorption and Micro X-ray Fluorescence Spectroscopy Investigation of Copper and Zinc Speciation in Biosolids

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Biochemistry ◽  
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J. A. Fee

1981 ◽  
Vol 670 (3) ◽  
pp. 312-315 ◽  
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2005 ◽  
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A S Vinogradov ◽  
A B Preobrajenski ◽  
L K Gridneva ◽  
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JOAN BORDAS ◽  
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2012 ◽  
Vol 65 (3) ◽  
pp. 204 ◽  
Author(s):  
Carolyn Therese Dillon

This review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed.


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