scholarly journals Species-Specific Differences and Structure−Activity Relationships in the Debromination of PBDE Congeners in Three Fish Species

2011 ◽  
Vol 45 (5) ◽  
pp. 1999-2005 ◽  
Author(s):  
Simon C. Roberts ◽  
Pamela D. Noyes ◽  
Evan P. Gallagher ◽  
Heather M. Stapleton
Keyword(s):  
Fish Species ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Species Specific

scholarly journals Antimicrobial Properties of Volatile Phenylpropanes

2010 ◽  
Vol 5 (9) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Alexander Pauli ◽  
Karl-Heinz Kubeczka
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Properties ◽  
Substitution Pattern ◽  
Structure Activity Relationships ◽  
Specific Effects ◽  
Structure Activity ◽  
Microbial Characteristics ◽  
Cis And Trans Isomers ◽  
Species Specific ◽  
Cis And Trans

The examination of antimicrobial structure-activity relationships of 93 volatile phenylpropanes (VPs) and 21 related aromatic compounds revealed a dependence of antimicrobial activity from the kind and number of substituents on the aromatic ring, their substitution pattern and microbial characteristics, such as Gram coloring and strain specific factors. Eugenol isomers were predominantly inhibitory in a concentration range from 25 to 2000 mg/L against all microorganisms tested, which were three strains of Escherichia Coli and Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, and Candida albicans. Etherified VPs were either less active or inactive depending on the type of side chain and/or substitution pattern. Differences in the antimicrobial activity of cis- and trans-isomers were observed. Species specific structure-activity relationships exist as was demonstrated with the Gram-negative bacteria (inactivity of E-ortho-eugenol) C. albicans (activity of di- and threefold methoxylated 1-propenylbenzenes), S. aureus and B. subtilis (activity of di-ortho methoxylated phenolic allylbenzenes and hydroquinone derivatives). With regard to the variety of observed specific effects and natural variation of susceptibility towards VPs according to literature reference data, the chances for successful prediction by computational analysis (QSAR) appear to be limited.

scholarly journals Thalidomide-type teratogenicity: structure–activity relationships for congeners

2018 ◽  
Vol 7 (6) ◽  
pp. 1036-1047 ◽  
Author(s):  
R. L. Smith ◽  
S. C. Mitchell
Keyword(s):  
Molecular Basis ◽  
Mature Animal ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Low Toxicity ◽  
Species Specific

Unravelling the molecular basis of thalidomide embryotoxicity, which is remarkably species-specific, is challenging in view of its low toxicity in the mature animal.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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