A Green Enantioselective Aldol Condensation for the Undergraduate Organic Laboratory

2006 ◽  
Vol 83 (12) ◽  
pp. 1871 ◽  
Author(s):  
George D. Bennett
Keyword(s):  
Aldol Condensation ◽  
Organic Laboratory

Michael addition and aldol condensation: A simple teaching model for organic laboratory

1986 ◽  
Vol 63 (5) ◽  
pp. 443 ◽  
Author(s):  
A. Garcia-Raso ◽  
J. Garcia-Raso ◽  
J. V. Sinisterra ◽  
R. Mestres
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Teaching Model ◽  
Organic Laboratory

Aldol condensation: A simple teaching model for organic laboratory

1978 ◽  
Vol 55 (8) ◽  
pp. 540 ◽  
Author(s):  
Byron L. Hawbecker ◽  
David W. Kurtz ◽  
Theodore D. Putnam ◽  
Patricia A. Ahlers ◽  
Gregory D. Gerber
Keyword(s):  
Aldol Condensation ◽  
Teaching Model ◽  
Organic Laboratory

scholarly journals Assessment of the Ratio of Geometric Isomers of Dibenzalacetone Spectroscopically

2019 ◽  
pp. 1-9
Author(s):  
Orwa Houshia ◽  
Abdalla Walwil ◽  
Hanan Jumaa ◽  
Hisham Qrareya ◽  
Harbi Daraghmeh ◽  
...  
Keyword(s):  
Gas Phase ◽  
Vibrational Frequency ◽  
Molar Mass ◽  
Aldol Condensation ◽  
Vibrational Modes ◽  
Geometric Isomers ◽  
Relative Ratio ◽  
Ft Ir ◽  
Organic Laboratory ◽  
Layer Chromatography

The aim of this experiment is to estimate the relative ratio of geometric isomers of Dibenzalacetone that was prepared via the crossed-aldol condensation by reacting benzaldehyde with acetone. Dibenzalacetone was synthesized in the lab from benzaldehyde and acetone under basic conditions. The GC-MS was used to relate the molar mass of the product. Thin layer chromatography was used to visualize the relative RF factor for each isomer. Uv-Vis instrument showed three peaks that were assigned to each isomer. And the FT-IR was used for the assignment of the vibrational modes of each isomer. The relative ratio of trans-trans, Cis-trans, and Cis-Cis was 59.87%, 26.53%, and 13.60% respectively with the aid of FT-IR instruments peak assignments were made for the vibrational frequency of the functional groups. For organic laboratory setups and practices, the fragments from the MS spectrum of DBA can be explained based on cleaving or rearrangement in gas phase by mechanisms known as α-cleavage, β-cleavage, and Rearrangement migration.

Characterization of Chemical Impurities in Glutaraldehyde

1975 ◽  
Vol 33 ◽  
pp. 620-621
Author(s):  
B. J. Grenon ◽  
A. J. Tousimis
Keyword(s):  
Glutaric Acid ◽  
Spectroscopic Analysis ◽  
Aldol Condensation ◽  
Condensation Product ◽  
Amorphous Solid ◽  
Water Soluble ◽  
Impurity Component ◽  
Chemical Impurities ◽  
Soluble Liquid

Ever since the introduction of glutaraldehyde as a fixative in electron microscopy of biological specimens, the identification of impurities and consequently their effects on biologic ultrastructure have been under investigation. Several reports postulate that the impurities of glutaraldehyde, used as a fixative, are glutaric acid, glutaraldehyde polymer, acrolein and glutaraldoxime.Analysis of commercially available biological or technical grade glutaraldehyde revealed two major impurity components, none of which has been reported. The first compound is a colorless, water-soluble liquid with a boiling point of 42°C at 16 mm. Utilizing Nuclear Magnetic Resonance (NMR) spectroscopic analysis, this compound has been identified to be — dihydro-2-ethoxy 2H-pyran. This impurity component of the glutaraldehyde biological or technical grades has an UV absorption peak at 235nm. The second compound is a white amorphous solid which is insoluble in water and has a melting point of 80-82°C. Initial chemical analysis indicates that this compound is an aldol condensation product(s) of glutaraldehyde.

Unexpected isolation of a cyclohexenone derivative

2019 ◽  
Vol 74 (11-12) ◽  
pp. 819-824
Author(s):  
Jürgen Voss ◽  
Rüdiger Röske ◽  
Gunnar Ehrlich ◽  
Gunadi Adiwidjaja
Keyword(s):  
Structure Determination ◽  
Aldol Condensation ◽  
Knoevenagel Reaction ◽  
X Ray

AbstractKnoevenagel reaction of pivaloylacetone with formaldehyde and subsequent aldol condensation ends up with 3-methyl-4,6-dipivaloylcyclohex-2-enone. The structure of the product is proved by an X-ray structure determination.

scholarly journals Nonanal Sensor Fabrication Using Aldol Condensation Reaction Inside Alkali-Resistant Porous Glass

2021 ◽  
pp. 1-1
Author(s):  
Masato Tsujiguchi ◽  
Takashi Aitoku ◽  
Hironori Takase ◽  
Yasuko Yamada Maru
Keyword(s):  
Porous Glass ◽  
Aldol Condensation ◽  
Condensation Reaction ◽  
Sensor Fabrication

An efficient click synthesis of chalcones derivatized with two 1-(2-quinolon-4-yl)-1,2,3-triazoles

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mohammed B. Alshammari ◽  
Ashraf A. Aly ◽  
Alan B. Brown ◽  
Md Afroz Bakht ◽  
Ahmed M. Shawky ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
Aldol Reaction ◽  
Click Synthesis

Abstract Chalcones derivatized with 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 4-azido-2-quinolones with 1-phenyl-3-(4-propargyloxyphenyl)prop-2-en-1-one, or by aldol reaction of 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes with acetophenone. Whereas, chalcones bearing two 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 1,3-bis(4-propargyloxyphenyl)prop-2-en-1-one with 4-azido-2-quinolones, or by aldol condensation between 4-{4-[(4-acetylphenoxy)methyl]-1H-1,2,3-triazol-1-yl}quinolin-2(1H)-ones and 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes.

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

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