Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment

2001 ◽  
Vol 78 (6) ◽  
pp. 786
Author(s):  
Andria Aroti ◽  
Epameinondas Leontidis
Keyword(s):  
Physical Chemistry ◽  
Simultaneous Determination ◽  
Ionization Constant ◽  
Drug Substances ◽  
Chemistry Experiment ◽  
Sparingly Soluble Drug

NMR Determination of Hydrogen Bond Thermodynamics in a Simple Diamide: A Physical Chemistry Experiment

2015 ◽  
Vol 92 (6) ◽  
pp. 1086-1090 ◽  
Author(s):  
Janine G. Morton ◽  
Candice L. Joe ◽  
Massiel C. Stolla ◽  
Sophia R. Koshland ◽  
Casey H. Londergan ◽  
...  
Keyword(s):  
Physical Chemistry ◽  
Hydrogen Bond ◽  
Chemistry Experiment

scholarly journals A validated stability-indicating LC method for simultaneous determination of quinapril and hydrochlorothiazide in pharmaceutical samples

2014 ◽  
Vol 12 (4) ◽  
pp. 470-475 ◽  
Author(s):  
Marta Diego ◽  
Sigrid Mennickent ◽  
Juan Muñoz ◽  
Fernanda Sanhueza ◽  
Ricardo Godoy
Keyword(s):  
Simultaneous Determination ◽  
Degradation Products ◽  
Stability Study ◽  
Pharmaceutical Samples ◽  
Stability Indicating ◽  
Drug Substances ◽  
Liquid Chromatographic Method ◽  
The Stability ◽  
Liquid Chromatographic

AbstractA stability-indicating liquid chromatographic method was developed and validated for simultaneous determination of quinapril and hydrochlorothiazide in drug substances and dosage forms. Chromatographic separation of quinapril, hydrochlorothiazide and its degradation products was achieved on a RP-18 column, using acetonitrile and phosphate buffer (pH 4.6) as mobile phase in a gradient mode and detection at 216 nm. Stress testing was performed under hydrolytic, oxidative, thermal and photolytic conditions. The degradation products were well resolved from main peaks, proving the stability-indicating power of the method. The assay was linear for quinapril and hydrochlorothiazide concentrations of 40–200 µg mL−1 and 25–125 µg mL−1, respectively. The developed method was selective, accurate and precise for quinapril and hydrochlorothiazide determination. This method was used to quantify both drugs in combined commercial tablets. The results showed that the proposed method was found to be suitable for quantitative determination and the stability study of quinapril and hydrochlorothiazide in pharmaceutical samples.

The Example of the Development of Multimedia Courseware Simulating Physical Chemistry Experiments

2011 ◽  
Vol 271-273 ◽  
pp. 1400-1403 ◽  
Author(s):  
Qing Xuan Zhang ◽  
Jing Wang
Keyword(s):  
Physical Chemistry ◽  
Vapor Pressure ◽  
Development Process ◽  
Saturated Vapor Pressure ◽  
Saturated Vapor ◽  
Student Evaluations ◽  
Good Effect ◽  
Developing Platform ◽  
Chemistry Experiment

The development process of software simulating physical chemistry experiments “The determination of saturated vapor pressure of liquid” as an example was shown based on Flash 8 software as a software developing platform and Photoshop as auxiliary software. The process of elements and instruments’ formation, the connection of instruments, the production of all kinds of scenes and their animation, the recording of sound, the simulation procedures were displayed. The courseware has been used in the physical chemistry experiment teaching. The good effect is obtained from the statistics of the student evaluations.

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