Identification of Pharmaceuticals via Computer-Aided Thin Layer Chromatography

2000 ◽  
Vol 77 (3) ◽  
pp. 366 ◽  
Author(s):  
Theodore J. Siek ◽  
Anthony J. Macherone
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Computer Aided ◽  
Layer Chromatography

Computer-aided optimization of stepwise gradient profiles in thin-layer chromatography

1992 ◽  
Vol 34 (5-8) ◽  
pp. 303-307 ◽  
Author(s):  
G. Matysik ◽  
W. Markowski ◽  
E. Soczewiński ◽  
B. Polak
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Computer Aided ◽  
Stepwise Gradient ◽  
Layer Chromatography

Thin-Layer Chromatography

1965 ◽  
Author(s):  
H. R. Bolliger ◽  
M. Brenner ◽  
H. Gänshirt ◽  
Helmut K. Mangold ◽  
H. Seiler ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Layer Chromatography

THE LESS-POLAR METABOLITES PRODUCED BY INCUBATION OF TESTOSTERONE-4-14C WITH RAT AND BOVINE BRAIN

1969 ◽  
Vol 61 (4) ◽  
pp. 641-648 ◽  
Author(s):  
Leon J. Sholiton ◽  
Emile E. Werk
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Paper Chromatography ◽  
Specific Activity ◽  
Bovine Brain ◽  
Polar Fraction ◽  
End Products ◽  
Polar Metabolites ◽  
Layer Chromatography ◽  
Constant Specific Activity

ABSTRACT Rat and bovine brain have been incubated with testosterone-4-14C under standard conditions. With use of paper chromatography, the extracted metabolites were noted to fall into less-polar, iso-polar, and more polar fractions. The components of the less-polar fraction were separated by acetylation and thin-layer chromatography and the major end-products identified by recrystallization to constant specific activity or constant 3H/14C ratios. Androst-4-enedione and 5α-dihydrotestosterone were formed consistently under the conditions utilized. Trace amounts of other less-polar metabolites were noted occasionally.

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