scholarly journals Bilinear Regression Analysis as a Means To Reduce Matrix Effects in Simultaneous Spectrophotometric Determination of Cr(III) and Co(II): A Quantitative Analysis Laboratory Experiment

1998 ◽  
Vol 75 (7) ◽  
pp. 878 ◽  
Author(s):  
Siddharth Pandey ◽  
Mary E. R. McHale ◽  
Karen S. Coym ◽  
William E. Acree
Keyword(s):  
Regression Analysis ◽  
Quantitative Analysis ◽  
Laboratory Experiment ◽  
Spectrophotometric Determination ◽  
Matrix Effects ◽  
Analysis Laboratory

Separation and Preconcentration of Sudan Blue II Using Membrane Filtration and UV-Visible Spectrophotometric Determination in River Water and Industrial Wastewater Samples

2015 ◽  
Vol 98 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Yunus Emre Unsal ◽  
Mustafa Tuzen ◽  
Mustafa Soylak
Keyword(s):  
Spectrophotometric Determination ◽  
Industrial Wastewater ◽  
Membrane Filtration ◽  
Matrix Effects ◽  
Membrane Filter ◽  
Cellulose Acetate Membrane ◽  
Separation And Preconcentration ◽  
Wastewater Samples ◽  
Working Media

Abstract A new separation and preconcentration method based on adsorption on a cellulose acetate membrane filter and elution with ethanol was established for the UV-Vis spectrophotometric determination of Sudan blue II. Various analytical parameters such as pH of working media, flow rates of solutions, and sample volumes were optimized. Matrix effects of concomitants were investigated for the quantitative recovery values of Sudan blue II. The preconcentration factor was200. LOD was calculated as 0.96 μg/L. RSD was5.1%. The optimized procedure was applied to the spectrophotometric determination of Sudan blue II in river and industrial wastewater samples from oil and dye products.

qHNMR Analysis of Purity of Common Organic Solvents—An Undergraduate Quantitative Analysis Laboratory Experiment

2017 ◽  
Vol 94 (12) ◽  
pp. 1969-1973 ◽  
Author(s):  
Peter T. Bell ◽  
W. Lance Whaley ◽  
Alyssa D. Tochterman ◽  
Karl S. Mueller ◽  
Linda D. Schultz
Keyword(s):  
Quantitative Analysis ◽  
Laboratory Experiment ◽  
Organic Solvents ◽  
Analysis Laboratory

scholarly journals Spectrophotometric Determination ofN-Acetyl-L-Cysteine andN-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Lea Kukoc-Modun ◽  
Njegomir Radić
Keyword(s):  
Regression Analysis ◽  
Detection Limit ◽  
Correlation Coefficient ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Complexation Reaction ◽  
Calibration Data ◽  
Pharmaceutical Excipients

A simple spectrophotometric method for the determination ofN-acetyl-L-cysteine (NAC) andN-(2-mercaptopropionyl)glycine (MPG) in pharmaceutical preparations was developed, validated, and used. The proposed equilibrium method is based on a coupled two-step redox and complexation reaction. In the first step, Fe(III) is reduced to Fe(II) by NAC or MPG. Subsequently, Fe(II) is complexed with 2,4,6-tripyridyl-s-triazine (TPTZ). Several analytical parameters of the method were optimized for NAC and MPG analysis in the concentration range from 1.0 μM to 100.0 μM. Regression analysis of the calibration data showed a good correlation coefficient (0.9999). The detection limit of the method was 0.14 μM for NAC and 0.13 μM for MPG. The method was successfully applied to quantify NAC and MPG in pharmaceutical preparations. No interferences were observed from common pharmaceutical excipients.

Research on Method about Determination of Condition-Based Maintenance Objects by Quantitative Analysis

2014 ◽  
Vol 635-637 ◽  
pp. 2023-2028
Author(s):  
Xiang Zan ◽  
Shi Xin Zhang ◽  
Yi Zheng ◽  
Yan Chao Liu
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Regression Analysis ◽  
Quantitative Analysis ◽  
Essential Role ◽  
Condition Based Maintenance ◽  
Traditional Methods

As an essential role in determination of condition-based maintenance (CBM) objects ,necessity and applicability analysis are both important. Necessity analysis is first and applicability analysis is second is proposed. Due to shortcoming of traditional methods, a quantitative is proposed. The key of method are criticality evaluation based on Monte Carlo simulation and applicability analysis based on regression analysis, which can solve the problem short of unite standard and influence by subjective factors. The result shows the model works well.

Spectrophotometric Determination of Isocarboxazid Bulk Drug and Tablets by Reaction with/7-Dimethylaminocinnamaldehyde

1988 ◽  
Vol 71 (6) ◽  
pp. 1134-1136
Author(s):  
Michael E El-Kommos
Keyword(s):  
Regression Analysis ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Trichloroacetic Acid ◽  
Excellent Correlation ◽  
Electrophilic Attack ◽  
Reagent Ratio ◽  
Bulk Drug ◽  
Methanolic Medium

Abstract A Spectrophotometric Method Is Described For The Determination Of Isocarboxazid. The Method Is Based On The Reaction Of The Drug With p-Dimethylaminocinnamaldehyde In The Presence Of Trichloroacetic Acid In A Methanolic Medium To Produce A Very Intense Red Chromophore (ℷmax = 500 Nm, Emax= 1.05 X 105). The Reaction Is Proposed To Proceed Via Electrophilic Attack At The C-4 Position Of The Isoxazole Nucleus. Job's Plot Indicated A 1:1 Drug-To-Reagent Ratio. Regression Analysis Of Beer's Plot Showed Excellent Correlation (R = 0.9996) In The Concentration Range 0.25-2.10 Fig Isocarboxazid/Ml. The Developed Color Is Stable For At Least 12 H. Results Of Analyses Of Bulk Drug And Tablets By The Proposed Method Are Comparable To Those For Usp Xxi Methods.

Comparison of Near-Infrared and Laser-Induced Breakdown Spectroscopy for Determination of Magnesium Stearate in Pharmaceutical Powders and Solid Dosage Forms

2005 ◽  
Vol 59 (3) ◽  
pp. 340-347 ◽  
Author(s):  
Robert L. Green ◽  
Mark D. Mowery ◽  
Julie A. Good ◽  
John P. Higgins ◽  
Steven M. Arrivo ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Near Infrared ◽  
Matrix Effects ◽  
Nir Spectroscopy ◽  
Magnesium Stearate ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Pharmaceutical Processing

Near-infrared (NIR) spectroscopy has become well established in both the pharmaceutical arena and other areas as a useful technique for rapid quantitative analysis of solid materials. Though laser-induced breakdown spectroscopy (LIBS) has not been widely applied in the pharmaceutical industry, the technique has been used for rapid quantitative analysis of solids in many other applications. One analysis amenable to each technique is the determination of magnesium stearate in solids during the lubrication blending unit operation of pharmaceutical processing. A comparative study of the utility of these two techniques for this application will be presented. Necessary sample preparations and the extent and type of matrix effects will be discussed. Additionally, it will be shown that NIR provides better accuracy and precision than LIBS with the experimental parameters used; however, LIBS showed superior selectivity as it was demonstrated to be more robust to sample matrix perturbations. Examples of blending applications will also be presented.

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