The kinetics of Mo(CO)6 substitution monitored by Fourier transform infrared spectrophotometry: A physical chemistry experiment

1987 ◽  
Vol 64 (6) ◽  
pp. 547 ◽  
Author(s):  
Kenneth S. Suslick ◽  
Edward B. Flint ◽  
James A. Jensen
2021 ◽  
Vol 7 (2) ◽  
pp. 168-177
Author(s):  
Nerdy Nerdy ◽  
Linda Margata ◽  
Dian Ika Perbina Meliala ◽  
Bunga Mari Sembiring ◽  
Selamat Ginting ◽  
...  

The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry method to identify and determine metformin hydrochloride in marketed tablet dosage form. This research included preparation of standard, analysis of samples, and validation of method. The specific wavenumber obtained for qualitative analysis was 1645.68 cm–1 and 1574.8 cm–1. The specific area obtained for quantitative analysis with a single baseline ranged from 1701.53 cm–1 to 1535.66 cm–1. All metformin hydrochloride marketed tablet dosage forms were analyzed and met all of the qualitative and quantitative requirements. The methods met the requirements of method validation for accuracy with a percentage of recovery of 100.22 %, precision with relative standard deviation of 0.48 %, linearity with a correlation coefficient of 0.9992, limit of detection of 11.17 mg per mL, limit of quantitation of 33.84 mg per mL, and good specificity results. In this study, the Fourier Transform Infrared spectrophotometry method was successfully developed and validated for application in identification and determination of metformin hydrochloride in marketed tablet dosage form.


Author(s):  
Himawan Tri Bayu Murti Petrus ◽  
Arie Satya Adelizar ◽  
Achmad Widiyatmoko ◽  
Muhammad Olvianas ◽  
Wisnu Suprapta ◽  
...  

2009 ◽  
Vol 17 (4) ◽  
pp. 303-306 ◽  
Author(s):  
Andrei A. Bunaciu ◽  
Gabriela Elena Udristioiu ◽  
Lavinia L. Ruţă ◽  
Şerban Fleschin ◽  
Hassan Y. Aboul-Enein

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