scholarly journals Interdisciplinary approaches to chemistry (IAC): Reactions and Reasons (1978), Diversity and periodicity (1978), Form and function (1978), Communities of molecules (1978), Molecules in living systems (1978), The heart of matter (1980), and The delicate balance (1980)

1982 ◽  
Vol 59 (7) ◽  
pp. A222
Author(s):  
A. M. Sarquis
Keyword(s):  
Living Systems ◽  
Form And Function ◽  
Delicate Balance ◽  
Interdisciplinary Approaches ◽  
And Function

scholarly journals Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Maria Grazia Masiello ◽  
Alessandra Cucina ◽  
Sara Proietti ◽  
Alessandro Palombo ◽  
Pierpaolo Coluccia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Simulated Microgravity ◽  
Living Systems ◽  
Functional Changes ◽  
Form And Function ◽  
Mediated Effects ◽  
Proliferation And Apoptosis ◽  
Cell Processes ◽  
Morphological Differences ◽  
And Function

Microgravity exerts dramatic effects on cell morphology and functions, by disrupting cytoskeleton and adhesion structures, as well as by interfering with biochemical pathways and gene expression. Impairment of cells behavior has both practical and theoretical significance, given that investigations of mechanisms involved in microgravity-mediated effects may shed light on how biophysical constraints cooperate in shaping complex living systems. By exposing breast cancer MDA-MB-231 cells to simulated microgravity (~0.001 g), we observed the emergence of two morphological phenotypes, characterized by distinct membrane fractal values, surface area, and roundness. Moreover, the two phenotypes display different aggregation profiles and adherent behavior on the substrate. These morphological differences are mirrored by the concomitant dramatic functional changes in cell processes (proliferation and apoptosis) and signaling pathways (ERK, AKT, and Survivin). Furthermore, cytoskeleton undergoes a dramatic reorganization, eventually leading to a very different configuration between the two populations. These findings could be considered adaptive and reversible features, given that, by culturing microgravity-exposed cells into a normal gravity field, cells are enabled to recover their original phenotype. Overall these data outline the fundamental role gravity plays in shaping form and function in living systems.

scholarly journals Institusioneel vasgeloop? Die Nederduitsch Hervormde Kerk van Afrika

2017 ◽  
Vol 73 (1) ◽  
Author(s):  
Petrus L. Steenkamp
Keyword(s):  
Jesus Christ ◽  
Economic Situation ◽  
Living Systems ◽  
Form And Function ◽  
Systems Perspective ◽  
Reformed Church ◽  
Organic Growth ◽  
And Function ◽  
The Church ◽  
Precarious Situation

The Netherdutch Reformed Church (Nederduitsch Hervormde Kerk van Afrika) finds itself in a precarious situation. It could be described as a watershed moment in the life of this denomination. The impasse developed due to various factors such as the loss of membership, the economic situation, ecumenical isolation and various other influences, which eventually resulted in a strong institutionalised organisation. Institutionalisation necessarily resulted in a shift of focus from the essence of being Church towards institutional continuation. As a result, the organic growth of the church suffered. This article investigates the institutionalism of the Netherdutch Reformed Church from an open (living) systems perspective, thereby identifying the dysfunctionality between form and function and ending with certain perspectives in respect of a change in focus by the church to realise the true essence of being Church of Jesus Christ.

Scanning tunneling microscopy (STM) of DNA and RNA

1989 ◽  
Vol 47 ◽  
pp. 34-35
Author(s):  
Patricia G. Arscott ◽  
Gil Lee ◽  
Victor A. Bloomfield ◽  
D. Fennell Evans
Keyword(s):  
Molecular Structures ◽  
Inorganic Materials ◽  
Resolving Power ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Form And Function ◽  
Dna And Rna ◽  
Calf Thymus ◽  
And Function ◽  
The Relationship

STM is one of the most promising techniques available for visualizing the fine details of biomolecular structure. It has been used to map the surface topography of inorganic materials in atomic dimensions, and thus has the resolving power not only to determine the conformation of small molecules but to distinguish site-specific features within a molecule. That level of detail is of critical importance in understanding the relationship between form and function in biological systems. The size, shape, and accessibility of molecular structures can be determined much more accurately by STM than by electron microscopy since no staining, shadowing or labeling with heavy metals is required, and there is no exposure to damaging radiation by electrons. Crystallography and most other physical techniques do not give information about individual molecules.We have obtained striking images of DNA and RNA, using calf thymus DNA and two synthetic polynucleotides, poly(dG-me5dC)·poly(dG-me5dC) and poly(rA)·poly(rU).

Re-examining the form and function of superstition

2011 ◽  
Author(s):  
Scott Fluke ◽  
Russell J. Webster ◽  
Donald A. Saucier
Keyword(s):  
Form And Function ◽  
And Function

A New Form and Function for Personality

2013 ◽  
Author(s):  
Joshua Wilt ◽  
William Revelle
Keyword(s):  
Form And Function ◽  
New Form ◽  
And Function

Ausnahmesegment

2018 ◽  
Vol 48 (191) ◽  
Author(s):  
Barbara Schönig
Keyword(s):  
Welfare State ◽  
Social Housing ◽  
Integrated Approach ◽  
New Paradigm ◽  
Development Models ◽  
Form And Function ◽  
Institutional Organization ◽  
National Welfare ◽  
And Function ◽  
The Welfare State

Going along with the end of the “golden age” of the welfare state, the fordist paradigm of social housing has been considerably transformed. From the 1980s onwards, a new paradigm of social housing has been shaped in Germany in terms of provision, institutional organization and design. This transformation can be interpreted as a result of the interplay between the transformation of national welfare state and housing policies, the implementation of entrepreneurial urban policies and a shift in architectural and urban development models. Using an integrated approach to understand form and function of social housing, the paper characterizes the new paradigm established and nevertheless interprets it within the continuity of the specific German welfare resp. housing regime, the “German social housing market economy”.

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