Determination of the absolute stereochemistry of secondary alcohols: An advanced organic chemistry experiment for undergraduate students

1980 ◽  
Vol 57 (11) ◽  
pp. 828 ◽  
Author(s):  
Wickramasinghe M. Bandaranayake
Keyword(s):  
Organic Chemistry ◽  
Undergraduate Students ◽  
Secondary Alcohols ◽  
The Absolute ◽  
Chemistry Experiment ◽  
Absolute Stereochemistry

Determination of the Absolute Stereochemistry of Cyclosmenospongine

2003 ◽  
Vol 66 (9) ◽  
pp. 1263-1265 ◽  
Author(s):  
Natalia K. Utkina ◽  
Vladimir A. Denisenko ◽  
Olga V. Scholokova ◽  
Aleksandra E. Makarchenko
Keyword(s):  
The Absolute ◽  
Absolute Stereochemistry

First synthesis and determination of the absolute stereochemistry of iso-cladospolide-B and cladospolides-B and C

2006 ◽  
Vol 47 (37) ◽  
pp. 6537-6540 ◽  
Author(s):  
G.V.M. Sharma ◽  
K. Laxmi Reddy ◽  
J. Janardhan Reddy
Keyword(s):  
The Absolute ◽  
Absolute Stereochemistry

The development of Chinese undergraduate students’ competence of scientific writing in the context of an advanced organic chemistry experiment course

2019 ◽  
Vol 20 (1) ◽  
pp. 270-287 ◽  
Author(s):  
Yang Deng ◽  
Gregory J. Kelly ◽  
Lishi Xiao
Keyword(s):  
Organic Chemistry ◽  
Undergraduate Students ◽  
Scientific Information ◽  
Scientific Writing ◽  
Scientific Practices ◽  
Chemistry Experiment ◽  
Development Of Students

This study examines scientific practices associated with scientific writing in organic chemistry in China. Although there is rapidly growing literature on the features and strategies of scientific writing, further research in this area is needed to recognize and treat scientific writing as a social endeavor to evaluate it in a more comprehensive and detailed way in order to effectively convey scientific information to readers. This study shared these important premises and attempted to investigate the development of Chinese undergraduate students’ competence of scientific writing. Twenty-two undergraduate students majoring in chemistry participated in this study. They experienced a researcher-intervenedAdvanced Organic Chemistry Experimentcourse and were asked to write scientific articles on the six course experiments. Their scientific writings were analyzed based on normativity, objectivity, and logicality. These dimensions of the development of students’ competence in scientific writing during the course were portrayed. This study suggested that student's development in scientific writing can be divided into categories, demonstrating the importance and implications of teaching “learn to write” in science.

scholarly journals Absolute Stereochemistry of the β-Hydroxy Acid Unit in Hantupeptins and Trungapeptins

2016 ◽  
Vol 11 (1) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Deepak Kumar Gupta ◽  
Gary Chi Ying Ding ◽  
Yong Chua Teo ◽  
Lik Tong Tan
Keyword(s):  
Amino Acid ◽  
Structural Feature ◽  
Absolute Configuration ◽  
Hydroxy Acid ◽  
Hplc Analysis ◽  
The Absolute ◽  
Absolute Stereochemistry ◽  
Common Structural Feature ◽  
Acid Unit

The β-hydroxy/amino acid unit is a common structural feature of many bioactive marine cyanobacterial depsipeptides. In this study, the absolute stereochemistry of the β-hydroxy acid moieties in hantupeptins and trungapeptins were determined through their synthesis and HPLC analysis of the Mosher ester derivatives. Synthesis of two3-hydroxy-2-methyloctanoic acid (Hmoa) stereoisomers, (2 S,3 R)-Hmoa and (2 S,3 S)-Hmoa, were achieved using diastereoselective asymmetric method and the retention times of all four Hmoa isomers were established indirectly by RPLC-MS analysis of their Mosher ester derivative standards. Based on the retention times of the standards, the absolute configuration of the Hmoa unit in hantupeptin C (3) and trungapeptin C (6) was assigned as (2 R,3 S)- and (2 S,3 R)-Hmoa, respectively. The use of the Mosher's reagents, coupled with HPLC analysis, provided a viable alternative to the absolute stereochemical determination of β-hydroxy acid units in depsipeptides.

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