scholarly journals Technique of organic chemistry. volume VII: organic solvents

1955 ◽  
Vol 32 (11) ◽  
pp. 602
Author(s):  
G. Ross Robertson
Keyword(s):  
Organic Chemistry ◽  
Organic Solvents

scholarly journals Efficient and Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach

2020 ◽  
Author(s):  
Vittorio Canale ◽  
Valeria Frisi ◽  
Xavier Bantreil ◽  
Frédéric Lamaty ◽  
Paweł Zajdel
Keyword(s):  
Organic Chemistry ◽  
Receptor Antagonist ◽  
Ball Milling ◽  
Organic Solvents ◽  
Column Chromatography ◽  
Alkylating Agent ◽  
Synthetic Organic Chemistry ◽  
Final Compound ◽  
Excellent Tool

<div> <p>Recently, ball milling has become an excellent tool in synthetic organic chemistry as it offers several advantages over classical batch synthesis. Here, an efficient and sustainable mechanochemical procedure was developed to obtain <b>PZ-1361</b>, a potent and selective 5-HT<sub>7</sub> receptor antagonist, with significant antidepressant properties in rodents. The elaborated protocol limited the use of organic solvents, reduced the excess of the alkylating agent, and enabled to avoid column chromatography purification of intermediates and the final compound.</p> </div>

Ionic Liquid Promoted Eco-friendly and Efficient Synthesis of Six-membered Npolyheterocycles

2018 ◽  
Vol 15 (8) ◽  
pp. 1124-1146 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Chemistry ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Organic Solvents ◽  
Review Article ◽  
Environmentally Benign ◽  
Wide Range ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Reaction Media

Background: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the literature related to the total synthesis of six-membered N-polyheterocycles. Objective: Ionic liquids not only acted as environmentally benign reaction media but also as catalysts which afforded the very promising replacements of traditional molecular solvents in organic chemistry due to their stability, non-flammability, non-volatility and ease of recyclability. Ionic liquids are utilized in metal catalyzed reactions in place of organic solvents in the last years. It has attracted considerable attention in recent years. Ionic liquids acted as alternatives of organic solvents and these ILs are environment friendly. Conclusion: In the area of green chemistry ionic liquid assisted synthesis is a very promising technique which afforded a flexible platform for the formation of heterocycles. The influence of ILs on the development of efficient and new synthetic protocols over the last decade for the construction of N-polyheterocycles is featured in this review article. These synthetic strategies will continue to attract more attention and will find a wide range of applications in organic synthesis. In conclusion, ionic liquids assisted syntheses have become an efficient and powerful tool in organic chemistry quickly.

scholarly journals Efficient and Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach

2020 ◽  
Author(s):  
Vittorio Canale ◽  
Valeria Frisi ◽  
Xavier Bantreil ◽  
Frédéric Lamaty ◽  
Paweł Zajdel
Keyword(s):  
Organic Chemistry ◽  
Receptor Antagonist ◽  
Ball Milling ◽  
Organic Solvents ◽  
Column Chromatography ◽  
Alkylating Agent ◽  
Synthetic Organic Chemistry ◽  
Final Compound ◽  
Excellent Tool

<div> <p>Recently, ball milling has become an excellent tool in synthetic organic chemistry as it offers several advantages over classical batch synthesis. Here, an efficient and sustainable mechanochemical procedure was developed to obtain <b>PZ-1361</b>, a potent and selective 5-HT<sub>7</sub> receptor antagonist, with significant antidepressant properties in rodents. The elaborated protocol limited the use of organic solvents, reduced the excess of the alkylating agent, and enabled to avoid column chromatography purification of intermediates and the final compound.</p> </div>

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