Mechanism of Assembling Isoprenoid Building Blocks 1. Elucidation of the Structural Motifs for Substrate Binding in Geranyl Pyrophosphate Synthase

2014 ◽  
Vol 10 (11) ◽  
pp. 5057-5067 ◽  
Author(s):  
Zhihong Liu ◽  
Jingwei Zhou ◽  
Ruibo Wu ◽  
Jun Xu
Keyword(s):  
Substrate Binding ◽  
Building Blocks ◽  
Structural Motifs ◽  
Geranyl Pyrophosphate Synthase ◽  
Geranyl Pyrophosphate

Electrocatalytic Difunctionalization of Olefins as a General Approach to the Synthesis of Vicinal Diamines

Synlett ◽  
2018 ◽  
Vol 29 (03) ◽  
pp. 257-265 ◽  
Author(s):  
Song Lin ◽  
Joseph Parry ◽  
Niankai Fu
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Therapeutic Agents ◽  
Recent Contribution ◽  
Structural Motifs ◽  
Bioactive Natural Products ◽  
Methodological Approaches ◽  
Molecular Catalysts ◽  
Vicinal Diamines

Vicinal diamines are highly prevalent structural motifs in therapeutic agents, bioactive natural products, and molecular catalysts. However, there are currently few unified methodological approaches for making these pertinent synthetic building blocks. This Synpacts article provides an overview of selected landmark developments in the area of olefin diamination. In particular, we highlight our recent contribution on the electrocatalytic diazidation of olefins as a general, selective, and sustainable method for the synthesis of vicinal diamines.1 Introduction2 Background: Intermolecular Diamination of Olefins3 Background: Intermolecular Diazidation of Olefins4 Electrocatalytic Diazidation of Olefins

scholarly journals Nanoarchitectonics for Hierarchical Fullerene Nanomaterials

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2146
Author(s):  
Subrata Maji ◽  
Lok Kumar Shrestha ◽  
Katsuhiko Ariga
Keyword(s):  
Organic Compound ◽  
Volatile Organic Compound ◽  
Hierarchical Structures ◽  
Functional Materials ◽  
Building Blocks ◽  
Review Article ◽  
Structural Motifs ◽  
Fullerenes C60 And C70 ◽  
Volatile Organic

Nanoarchitectonics is a universal concept to fabricate functional materials from nanoscale building units. Based on this concept, fabrications of functional materials with hierarchical structural motifs from simple nano units of fullerenes (C60 and C70 molecules) are described in this review article. Because fullerenes can be regarded as simple and fundamental building blocks with mono-elemental and zero-dimensional natures, these demonstrations for hierarchical functional structures impress the high capability of the nanoarchitectonics approaches. In fact, various hierarchical structures such as cubes with nanorods, hole-in-cube assemblies, face-selectively etched assemblies, and microstructures with mesoporous frameworks are fabricated by easy fabrication protocols. The fabricated fullerene assemblies have been used for various applications including volatile organic compound sensing, microparticle catching, supercapacitors, and photoluminescence systems.

scholarly journals The Structural Motifs for Substrate Binding and Dimerization of the α Subunit of Collagen Prolyl 4-Hydroxylase

Structure ◽  
2013 ◽  
Vol 21 (12) ◽  
pp. 2107-2118 ◽  
Author(s):  
Jothi Anantharajan ◽  
M. Kristian Koski ◽  
Petri Kursula ◽  
Reija Hieta ◽  
Ulrich Bergmann ◽  
...  
Keyword(s):  
Substrate Binding ◽  
Structural Motifs ◽  
Α Subunit

scholarly journals Computer-Aid Directed Evolution of GPPS and PS Enzymes

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fei Chen ◽  
Hong Cheng ◽  
Jiaqi Zhu ◽  
Shiyu Wang ◽  
Liancheng Zhang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Yield Increase ◽  
Random Coils ◽  
Genetically Engineered Microorganisms ◽  
Biological Yield ◽  
Key Sites ◽  
Molecular Modeling And Docking ◽  
Flavoring Agent ◽  
Geranyl Pyrophosphate Synthase ◽  
Geranyl Pyrophosphate

Pinene, a natural active monoterpene, is widely used as a flavoring agent, perfume, medicine, and biofuel. Although genetically engineered microorganisms have successfully produced pinene, to date, the biological yield of pinene is much lower than that of semiterpenes (isoprene) and sesquiterpenes (farnesene). In addition to the low heterologous expression of geranyl pyrophosphate synthase (GPPS) and pinene synthase (PS), cytotoxicity due to accumulation of the monoterpene also limits the production of pinene in microorganisms. In this study, we attempted to use two strategies to increase the biological yield of pinene. By deleting the random coils of GPPS and PS alone or in combination, a strain with a 335% yield increase was obtained. Additionally, upon computer-guided molecular modeling and docking of GPPS with isopentenyl pyrophosphate (IPP), its substrate, the key sites located within the catalytic pocket for substrate binding, was predicted. After screening, a strain harboring the T273R mutation of GPPS was selected among a batch of mutations of the key sites with a 154% increase in pinene yield.

Carbenoid-Mediated Homologation Tactics for Assembling (Fluorinated) Epoxides and Aziridines

Synlett ◽  
2020 ◽  
Author(s):  
Laura Ielo ◽  
Vittorio Pace ◽  
Veronica Pillari ◽  
Margherita Miele ◽  
Davide Castiglione
Keyword(s):  
Case Studies ◽  
Organic Synthesis ◽  
Building Blocks ◽  
Carbon Skeleton ◽  
Illustrative Case ◽  
Reaction Conditions ◽  
Structural Motifs ◽  
Fluorinated Building Blocks ◽  
Single Operation

Homologation strategies provide highly versatile tools in organic synthesis for the introduction of a CH2 group into a given carbon skeleton. The operation can result in diverse structural motifs by tuning of the reaction conditions and the nature of the homologating agent. In this Account, concisely contextualizing our work with lithium carbenoids (LiCH2X, LiCHXY etc) for homologating carbon-centered electrophiles, we focus on the assembly of three-membered cycles featuring fluorinated substituents. Two illustrative case studies are considered: (1) the development and employment of fluorinated carbenoids en route to rare α-fluoroepoxides and aziridines, and (2) the installation of up to halomethylenic groups on trifluoroimidoylacetyl chlorides (TFAICs) for preparing CF3-containing halo- and halomethylaziridines. Collectively, we demonstrate that the initial homologation event generated by the installation of the carbenoid, upon modulation of the conditions, serves as a tool for creating fluorinated building blocks in a single operation.

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