Development of Preformed Pd Catalysts for Cross-Coupling Reactions, Beyond the 2010 Nobel Prize

ACS Catalysis ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 1147-1164 ◽  
Author(s):  
Hongbo Li ◽  
Carin C. C. Johansson Seechurn ◽  
Thomas J. Colacot
Keyword(s):  
Nobel Prize ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Pd Catalysts ◽  
Cross Coupling Reactions

ChemInform Abstract: Development of Preformed Pd Catalysts for Cross-Coupling Reactions, Beyond the 2010 Nobel Prize

ChemInform ◽  
2012 ◽  
Vol 43 (30) ◽  
pp. no-no
Author(s):  
Hongbo Li ◽  
Carin C. C. Johansson Seechurn ◽  
Thomas J. Colacot
Keyword(s):  
Nobel Prize ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Pd Catalysts ◽  
Cross Coupling Reactions

Pd catalysts supported on hydrogen titanate nanotubes for Suzuki-Miyaura cross-coupling reactions

2018 ◽  
Vol 305 ◽  
pp. 58-64 ◽  
Author(s):  
Mark E. Martínez-Klimov ◽  
Patricia Hernández-Hipólito ◽  
Marcos Martínez-García ◽  
Tatiana E. Klimova
Keyword(s):  
Cross Coupling ◽  
Titanate Nanotubes ◽  
Coupling Reactions ◽  
Pd Catalysts ◽  
Cross Coupling Reactions ◽  
Hydrogen Titanate

scholarly journals High-Valent NiIII and NiIV Species Relevant to C–C and C–Heteroatom Cross-Coupling Reactions: State of the Art

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1141 ◽  
Author(s):  
Noel Nebra
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Ni Catalysts ◽  
Pd Catalysts ◽  
Ligand Interaction ◽  
Bond Functionalization ◽  
Cross Coupling Reactions ◽  
Active Research ◽  
High Valent

Ni catalysis constitutes an active research arena with notable applications in diverse fields. By analogy with its parent element palladium, Ni catalysts provide an appealing entry to build molecular complexity via cross-coupling reactions. While Pd catalysts typically involve a M0/MII redox scenario, in the case of Ni congeners the mechanistic elucidation becomes more challenging due to their innate properties (like enhanced reactivity, propensity to undergo single electron transformations vs. 2e− redox sequences or weaker M–Ligand interaction). In recent years, mechanistic studies have demonstrated the participation of high-valent NiIII and NiIV species in a plethora of cross-coupling events, thus accessing novel synthetic schemes and unprecedented transformations. This comprehensive review collects the main contributions effected within this topic, and focuses on the key role of isolated and/or spectroscopically identified NiIII and NiIV complexes. Amongst other transformations, the resulting NiIII and NiIV compounds have efficiently accomplished: i) C–C and C–heteroatom bond formation; ii) C–H bond functionalization; and iii) N–N and C–N cyclizative couplings to forge heterocycles.

scholarly journals Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

2018 ◽  
Vol 14 ◽  
pp. 648-658 ◽  
Author(s):  
Katharina Hiebler ◽  
Georg J Lichtenegger ◽  
Manuel C Maier ◽  
Eun Sung Park ◽  
Renie Gonzales-Groom ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Cross Coupling ◽  
Single Step ◽  
Molecular Formula ◽  
Coupling Reactions ◽  
Pickering Emulsions ◽  
Solution Combustion ◽  
Pd Catalysts ◽  
Catalytic Systems ◽  
Cross Coupling Reactions

Within the “compartmentalised smart factory” approach of the ONE-FLOW project the implementation of different catalysts in “compartments” provided by Pickering emulsions and their application in continuous flow is targeted. We present here the development of heterogeneous Pd catalysts that are ready to be used in combination with biocatalysts for catalytic cascade synthesis of active pharmaceutical ingredients (APIs). In particular, we focus on the application of the catalytic systems for Suzuki–Miyaura cross-coupling reactions, which is the key step in the synthesis of the targeted APIs valsartan and sacubitril. An immobilised enzyme will accomplish the final product formation via hydrolysis. In order to create a large interfacial area for the catalytic reactions and to keep the reagents separated until required, the catalyst particles are used to stabilise Pickering emulsions of oil and water. A set of Ce–Sn–Pd oxides with the molecular formula Ce0.99− x Sn x Pd0.01O2−δ (x = 0–0.99) has been prepared utilising a simple single-step solution combustion method. The high applicability of the catalysts for different functional groups and their minimal leaching behaviour is demonstrated with various Suzuki–Miyaura cross-coupling reactions in batch as well as in continuous flow employing the so-called “plug & play reactor”. Finally, we demonstrate the use of these particles as the sole emulsifier of oil–water emulsions for a range of oils.

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