DNA Polymerase γ in Mitochondrial DNA Replication and Repair

2006 ◽  
Vol 106 (2) ◽  
pp. 383-405 ◽  
Author(s):  
Maria A. Graziewicz ◽  
Matthew J. Longley ◽  
William C. Copeland
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Replication And Repair ◽  
Mitochondrial Dna Replication ◽  
Dna Polymerase Γ

DNA Polymerase γ in Mitochondrial DNA Replication and Repair

ChemInform ◽  
2006 ◽  
Vol 37 (21) ◽  
Author(s):  
Maria A. Graziewicz ◽  
Matthew J. Longley ◽  
William C. Copeland
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Replication And Repair ◽  
Mitochondrial Dna Replication ◽  
Dna Polymerase Γ

scholarly journals The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Bertil Macao ◽  
Jay P. Uhler ◽  
Triinu Siibak ◽  
Xuefeng Zhu ◽  
Yonghong Shi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Exonuclease Activity ◽  
Mitochondrial Dna Replication ◽  
Dna Polymerase Γ

scholarly journals Mitochondrial DNA replication does not involve DNA polymerase alpha.

1980 ◽  
Vol 255 (24) ◽  
pp. 11847-11852
Author(s):  
W. Zimmermann ◽  
S.M. Chen ◽  
A. Bolden ◽  
A. Weissbach
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerase Alpha ◽  
Mitochondrial Dna Replication

PrimPol (Primase/Polymerase), replicating enzyme – A mini review

2020 ◽  
Vol 2 (4) ◽  
pp. 89-92
Author(s):  
Muhammad Amir ◽  
Sabeera Afzal ◽  
Alia Ishaq
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Genetic Information ◽  
Nuclear Dna ◽  
De Novo ◽  
Dna Polymerases ◽  
Test Site ◽  
Mitochondrial Dna Replication ◽  
Dna Template ◽  
Preliminary Phase

Polymerases were revealed first in 1970s. Most important to the modest perception the enzyme responsible for nuclear DNA replication that was pol , for DNA repair pol and for mitochondrial DNA replication pol  DNA construction and renovation done by DNA polymerases, so directing both the constancy and discrepancy of genetic information. Replication of genome initiate with DNA template-dependent fusion of small primers of RNA. This preliminary phase in replication of DNA demarcated as de novo primer synthesis which is catalyzed by specified polymerases known as primases. Sixteen diverse DNA-synthesizing enzymes about human perspective are devoted to replication, reparation, mutilation lenience, and inconsistency of nuclear DNA. But in dissimilarity, merely one DNA polymerase has been called in mitochondria. It has been suggest that PrimPol is extremely acting the roles by re-priming DNA replication in mitochondria to permit an effective and appropriate way replication to be accomplished. Investigations from a numeral of test site have significantly amplified our appreciative of the role, recruitment and regulation of the enzyme during DNA replication. Though, we are simply just start to increase in value the versatile roles that play PrimPol in eukaryote.

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