Synthesis and Properties of Oligocyclopropyl-Containing Natural Products and Model Compounds

2003 ◽  
Vol 103 (4) ◽  
pp. 1051-1070 ◽  
Author(s):  
Jörg Pietruszka
Keyword(s):  
Natural Products ◽  
Model Compounds

scholarly journals Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 3 ◽  
Author(s):  
Takehiro Matsubara ◽  
Masashi Yokoya ◽  
Natchanun Sirimangkalakitti ◽  
Naoki Saito
Keyword(s):  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Natural Products ◽  
Asymmetric Synthesis ◽  
Active Compound ◽  
Hct116 Cell ◽  
Human Prostate Cancer ◽  
Model Compounds ◽  
Structure Activity ◽  
Sar Study

A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure–activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate cancer DU145 and colorectal cancer HCT116 cell lines (IC50 = 11.9, and 12.5 nM, respectively).

scholarly journals 1H-NMR as a Structural and Analytical Tool of Intra- and Intermolecular Hydrogen Bonds of Phenol-Containing Natural Products and Model Compounds

Molecules ◽  
2014 ◽  
Vol 19 (9) ◽  
pp. 13643-13682 ◽  
Author(s):  
Pantelis Charisiadis ◽  
Vassiliki Kontogianni ◽  
Constantinos Tsiafoulis ◽  
Andreas Tzakos ◽  
Michael Siskos ◽  
...  
Keyword(s):  
Natural Products ◽  
Hydrogen Bonds ◽  
1H Nmr ◽  
Analytical Tool ◽  
Model Compounds ◽  
Intermolecular Hydrogen Bonds
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