Cytochrome c oxidase as a redox-linked proton pump

1990 ◽  
Vol 90 (7) ◽  
pp. 1247-1260 ◽  
Author(s):  
Bo G. Malmstroem
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump

scholarly journals Cytochrome c Oxidase is a proton pump

FEBS Letters ◽  
1978 ◽  
Vol 91 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Mårten Wikström ◽  
Klaas Krab
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump

Proton pump coupled to cytochrome c oxidase in mitochondria

Nature ◽  
1977 ◽  
Vol 266 (5599) ◽  
pp. 271-273 ◽  
Author(s):  
MARTEN K. F. WIKSTROM
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump

scholarly journals Exploring the proton pump mechanism of cytochrome c oxidase in real time

2007 ◽  
Vol 104 (8) ◽  
pp. 2685-2690 ◽  
Author(s):  
I. Belevich ◽  
D. A. Bloch ◽  
N. Belevich ◽  
M. Wikstrom ◽  
M. I. Verkhovsky
Keyword(s):  
Cytochrome C ◽  
Real Time ◽  
Cytochrome C Oxidase ◽  
Proton Pump ◽  
Pump Mechanism

scholarly journals Kinetic gating of the proton pump in cytochrome c oxidase

2009 ◽  
Vol 106 (33) ◽  
pp. 13707-13712 ◽  
Author(s):  
Y. C. Kim ◽  
M. Wikstrom ◽  
G. Hummer
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump

scholarly journals Limited-turnover studies on proton translocation in reconstituted cytochrome c oxidase-containing vesicles

1979 ◽  
Vol 182 (1) ◽  
pp. 149-156 ◽  
Author(s):  
R P Casey ◽  
J B Chappell ◽  
A Azzi
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump ◽  
Proton Translocation ◽  
Strong Support ◽  
Ferrocytochrome C ◽  
Vesicle Membranes ◽  
Careful Control ◽  
Hydrogen Carrier ◽  
Reconstituted System

We have investigated ferrocytochrome c-induced proton ejection from reconstituted cytochrome c oxidase-containing vesicles using careful control of the number of enzyme turnovers. Ferrocytochrome c caused the appearance of protons at the vesicle exterior, and this could be abolished by using a protonophore. In addition, its decay was dependent on the permeability of the vesicle membranes to protons and the number of turnovers of the oxidase. These observations indicate that the ejection of protons was the result of genuine translocation. The possibility of this translocation occurring via a Mitchellian loop as a result of the presence of a reduced hydrogen carrier contaminating the enzyme was considered and excluded. Proton-translocating activity in this reconstituted system depended critically on the ratio of enzyme to lipid used in the reconstitution process and we propose a rationale to account for this. We conclude that our data provide strong support for the proposal that cytochrome c oxidase acts as a proton pump and that approx. 0.9 H+ is excluded per ferrocytochrome c molecule oxidized.

scholarly journals Proton pump mechanism deduced from high resolution structures of bovine heart cytochrome c oxidase

2002 ◽  
Vol 58 (s1) ◽  
pp. c36-c36
Author(s):  
K. Muramoto ◽  
H. Aoyama ◽  
K. Hirata ◽  
E. Yamashita ◽  
T. Akitsu ◽  
...  
Keyword(s):  
High Resolution ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump ◽  
Bovine Heart ◽  
Pump Mechanism

Evidence against Proton Pump Activity by Cytochrome c Oxidase of Pseudomonas AM1

1987 ◽  
Vol 102 (3) ◽  
pp. 481-486 ◽  
Author(s):  
Nobuhito SONE ◽  
Mihoko SEKIMACHI ◽  
Yoshihiro FUKUMORI ◽  
Tateo YAMANAKA
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump ◽  
Pump Activity

scholarly journals Prevention of leak in the proton pump of cytochrome c oxidase

2008 ◽  
Vol 1777 (7-8) ◽  
pp. 890-892 ◽  
Author(s):  
Ville R.I. Kaila ◽  
Michael Verkhovsky ◽  
Gerhard Hummer ◽  
Mårten Wikström
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump
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