scholarly journals AC-186, a Selective Nonsteroidal Estrogen Receptor β Agonist, Shows Gender Specific Neuroprotection in a Parkinson’s Disease Rat Model

2013 ◽  
Vol 4 (9) ◽  
pp. 1249-1255 ◽  
Author(s):  
Krista McFarland ◽  
Diana L. Price ◽  
Christopher N. Davis ◽  
Jian-Nong Ma ◽  
Douglas W. Bonhaus ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Estrogen Receptor ◽  
Rat Model ◽  
Estrogen Receptor Β ◽  
Gender Specific

scholarly journals Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress

2019 ◽  
Vol 20 (7) ◽  
pp. 1772 ◽  
Author(s):  
Hyojung Kim ◽  
Jisoo Park ◽  
HyunHee Leem ◽  
MyoungLae Cho ◽  
Jin-Ha Yoon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Estrogen Receptor ◽  
Nuclear Translocation ◽  
Ring Finger ◽  
Cell Loss ◽  
Receptor Activation ◽  
Estrogen Receptor Β ◽  
Dopaminergic Cell ◽  
6 Hydroxydopamine

Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson’s disease (PD). Previously, we reported that rhododendrin is a chemical inducer that increases RNF146 expression. However, the molecular mechanism of rhododendrin-induced RNF146 expression is largely unknown and its translational application for the treatment of Parkinson’s disease remains unexplored. Here we found that rhododendrin increased RNF146 expression via estrogen receptor β (ERβ) activation. Rhododendrin stimulated ERβ nuclear translocation and binding to the RNF146 promoter, thereby enhancing its transcription. Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERβ activity and RNF146 expression. Finally, we demonstrated that rhododendrin treatment resulted in RNF146 expression in dopaminergic neurons in mice. Moreover, dopaminergic neuron viability was markedly enhanced by pretreatment with rhododendrin in 6-OHDA-induced mouse models for PD. Our findings indicate that estrogen receptor activation plays a neuroprotective role and that rhododendrin could be a potential therapeutic agent in preventing PARP1-dependent dopaminergic cell loss in PD.

In vivo multimodal (MRI, SPECT) imaging of the 6-OHDA rat model for Parkinson's disease correlated with behavior and histology

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S392-S392
Author(s):  
Nadja Van Camp ◽  
Koen Van Laere ◽  
Ruth Vreys ◽  
Marleen Verhoye ◽  
Erwin Lauwers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Spect Imaging ◽  
Multimodal Mri

Colchicine Protects Dopaminergic Neurons in a Rat Model of Parkinson's Disease

2012 ◽  
Vol 11 (7) ◽  
pp. 836-843 ◽  
Author(s):  
Mohamed Salama ◽  
Amr Ellaithy ◽  
Basem Helmy ◽  
Mohamed El-Gamal ◽  
Dina Tantawy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Dopaminergic Neurons

The Dynamics of Nigrostriatal System Damage and Neurobehavioral Changes in the Rotenone Rat Model of Parkinson's Disease

2021 ◽  
Author(s):  
Dmitry Troshev ◽  
Daniil Berezhnoy ◽  
Olga Kulikova ◽  
Denis Abaimov ◽  
Olga Muzychuk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Nigrostriatal System
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