scholarly journals Cationic Amino Acid Based Lipids as Effective Nonviral Gene Delivery Vectors for Primary Cultured Neurons

2013 ◽  
Vol 4 (12) ◽  
pp. 1514-1519 ◽  
Author(s):  
Yumiko Aoshima ◽  
Ryosuke Hokama ◽  
Keitaro Sou ◽  
Satya Ranjan Sarker ◽  
Kabuto Iida ◽  
...  
Keyword(s):  
Amino Acid ◽  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Cultured Neurons ◽  
Cationic Amino Acid ◽  
Gene Delivery Vectors ◽  
Primary Cultured Neurons

Lipid-Based Nanoparticles as Nonviral Gene Delivery Vectors

2013 ◽  
pp. 269-279 ◽  
Author(s):  
Daniele Pezzoli ◽  
Anna Kajaste-Rudnitski ◽  
Roberto Chiesa ◽  
Gabriele Candiani
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vectors

Nonviral Gene Delivery Vectors Use Syndecan-Dependent Transport Mechanisms in Filopodia To Reach the Cell Surface

ACS Nano ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 7521-7532 ◽  
Author(s):  
Zia ur Rehman ◽  
Klaas A. Sjollema ◽  
Jeroen Kuipers ◽  
Dick Hoekstra ◽  
Inge S. Zuhorn
Keyword(s):  
Gene Delivery ◽  
Cell Surface ◽  
Nonviral Gene Delivery ◽  
Transport Mechanisms ◽  
Gene Delivery Vectors ◽  
Dependent Transport

Engineered Glycated Amino Dendritic Polymers as Specific Nonviral Gene Delivery Vectors Targeting the Receptor for Advanced Glycation End Products

2014 ◽  
Vol 25 (6) ◽  
pp. 1151-1161 ◽  
Author(s):  
M. Dolores Giron-Gonzalez ◽  
Arturo Morales-Portillo ◽  
Alfonso Salinas-Castillo ◽  
F. Javier Lopez-Jaramillo ◽  
Fernando Hernandez-Mateo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Advanced Glycation End Products ◽  
Nonviral Gene Delivery ◽  
Dendritic Polymers ◽  
Advanced Glycation ◽  
Gene Delivery Vectors ◽  
Glycation End Products ◽  
End Products

scholarly journals Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors

2010 ◽  
Vol 12 (1) ◽  
pp. 64-76 ◽  
Author(s):  
Lei Chen ◽  
Huayu Tian ◽  
Jie Chen ◽  
Xuesi Chen ◽  
Yubin Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Glutamic Acid ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vectors

Alkyl sulfonyl derivatized PAMAM-G2dendrimers as nonviral gene delivery vectors with improved transfection efficiencies

2011 ◽  
Vol 9 (3) ◽  
pp. 851-864 ◽  
Author(s):  
Julia Morales-Sanfrutos ◽  
Alicia Megia-Fernandez ◽  
Fernando Hernandez-Mateo ◽  
Ma Dolores Giron-Gonzalez ◽  
Rafael Salto-Gonzalez ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vectors

Gemini Amphiphiles: A Novel Class of Nonviral Gene Delivery Vectors

2010 ◽  
Vol 27 (3) ◽  
pp. 237-278 ◽  
Author(s):  
Mukesh Kumar ◽  
Kaustubh Jinturkar ◽  
M.R. Yadav ◽  
Ambikanandan Misra
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vectors ◽  
Gemini Amphiphiles

scholarly journals Lipoaminoacids Enzyme-Based Production and Application as Gene Delivery Vectors

Catalysts ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 977 ◽  
Author(s):  
Maria Ribeiro ◽  
Patricia Carvalho ◽  
Tiago Martins ◽  
Célia Faustino
Keyword(s):  
Gene Therapy ◽  
Amino Acid ◽  
Gene Delivery ◽  
Condensation Reaction ◽  
Viral Gene ◽  
Amino Acid Residues ◽  
Gene Therapy Vector ◽  
Gene Delivery Vectors ◽  
Head Groups ◽  
Dna Vectors

Biosurfactant compounds have been studied in many applications, including biomedical, food, cosmetic, agriculture, and bioremediation areas, mainly due to their low toxicity, high biodegradability, and multifunctionality. Among biosurfactants, the lipoplexes of lipoaminoacids play a key role in medical and pharmaceutical fields. Lipoaminoacids (LAAs) are amino acid-based surfactants that are obtained from the condensation reaction of natural origin amino acids with fatty acids or fatty acid derivatives. LAA can be produced by biocatalysis as an alternative to chemical synthesis and thus become very attractive from both the biomedical and the environmental perspectives. Gemini LAAs, which are made of two hydrophobic chains and two amino acid head groups per molecule and linked by a spacer at the level of the amino acid residues, are promising candidates as both drug and gene delivery and protein disassembly agents. Gemini LAA usually show lower critical micelle concentration, interact more efficiently with proteins, and are better solubilising agents for hydrophobic drugs when compared to their monomeric counterparts due to their dimeric structure. A clinically relevant human gene therapy vector must overcome or avoid detect and silence foreign or misplaced DNA whilst delivering sustained levels of therapeutic gene product. Many non-viral DNA vectors trigger these defence mechanisms, being subsequently destroyed or rendered silent. The development of safe and persistently expressing DNA vectors is a crucial prerequisite for a successful clinical application, and it one of the main strategic tasks of non-viral gene therapy research.

Viral and Nonviral Gene Delivery Vectors for Cancer Gene Therapy

1998 ◽  
Vol 22 (5) ◽  
pp. 445-454 ◽  
Author(s):  
Richard J. Cristiano ◽  
Bo Xu ◽  
Dao Nguyen ◽  
Guido Schumacher ◽  
Masafumi Kataoka ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Cancer Gene Therapy ◽  
Nonviral Gene Delivery ◽  
Cancer Gene ◽  
Gene Delivery Vectors
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