Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators

Douglas J. Sheffler; Anthony B. Pinkerton; Russell Dahl; Athina Markou; Nicholas D. P. Cosford

doi:10.1021/cn200008d

Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators

ACS Chemical Neuroscience ◽

10.1021/cn200008d ◽

2011 ◽

Vol 2 (8) ◽

pp. 382-393 ◽

Cited By ~ 31

Author(s):

Douglas J. Sheffler ◽

Anthony B. Pinkerton ◽

Russell Dahl ◽

Athina Markou ◽

Nicholas D. P. Cosford

Keyword(s):

Glutamate Receptor ◽

Recent Progress ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Group Ii

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Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.040 ◽

2017 ◽

Vol 115 ◽

pp. 115-127 ◽

Cited By ~ 5

Author(s):

L. Lundström ◽

C. Bissantz ◽

J. Beck ◽

M. Dellenbach ◽

T.J. Woltering ◽

...

Keyword(s):

Molecular Characterization ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.10.026 ◽

2007 ◽

Vol 17 (24) ◽

pp. 6811-6815 ◽

Cited By ~ 15

Author(s):

Thomas J. Woltering ◽

Geo Adam ◽

Alexander Alanine ◽

Jürgen Wichmann ◽

Frédéric Knoflach ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Metabotropic Glutamate

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.12.005 ◽

2008 ◽

Vol 18 (3) ◽

pp. 1091-1095 ◽

Cited By ~ 12

Author(s):

Thomas J. Woltering ◽

Geo Adam ◽

Jürgen Wichmann ◽

Erwin Goetschi ◽

James N.C. Kew ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Metabotropic Glutamate

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Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics

Current Opinion in Pharmacology ◽

10.1016/j.coph.2014.11.003 ◽

2015 ◽

Vol 20 ◽

pp. 40-45 ◽

Cited By ~ 25

Author(s):

Adam G Walker ◽

P Jeffrey Conn

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Group I ◽

Group Ii

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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.02.076 ◽

2008 ◽

Vol 18 (8) ◽

pp. 2725-2729 ◽

Cited By ~ 12

Author(s):

Thomas J. Woltering ◽

Jürgen Wichmann ◽

Erwin Goetschi ◽

Geo Adam ◽

James N.C. Kew ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Metabotropic Glutamate

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Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.032 ◽

2016 ◽

Vol 111 ◽

pp. 253-265 ◽

Cited By ~ 3

Author(s):

L. Lundström ◽

C. Bissantz ◽

J. Beck ◽

M. Dellenbach ◽

T.J. Woltering ◽

...

Keyword(s):

Molecular Characterization ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

Download Full-text

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.09.125 ◽

2010 ◽

Vol 20 (23) ◽

pp. 6969-6974 ◽

Cited By ~ 29

Author(s):

Thomas J. Woltering ◽

Jürgen Wichmann ◽

Erwin Goetschi ◽

Frédéric Knoflach ◽

Theresa M. Ballard ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Metabotropic Glutamate

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Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia

Neuropharmacology ◽

10.1016/j.neuropharm.2011.06.007 ◽

2012 ◽

Vol 62 (3) ◽

pp. 1473-1483 ◽

Cited By ~ 66

Author(s):

Matthew J. Fell ◽

David L. McKinzie ◽

James A. Monn ◽

Kjell A. Svensson

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Novel Treatments ◽

Glutamate Receptor Agonists ◽

Positive Allosteric Modulators ◽

Group Ii

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Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00994 ◽

2018 ◽

Vol 62 (1) ◽

pp. 342-358 ◽

Cited By ~ 7

Author(s):

Sean R. Bollinger ◽

Darren W. Engers ◽

Joseph D. Panarese ◽

Mary West ◽

Julie L. Engers ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulators ◽

Biological Characterization ◽

Metabotropic Glutamate ◽

Structure Activity ◽

Positive Allosteric Modulators

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Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)

Pharmacological Reports ◽

10.1016/s1734-1140(11)70547-3 ◽

2011 ◽

Vol 63 (2) ◽

pp. 577

Author(s):

Piotr Brański ◽

Jakub Staroń ◽

Ryszard Bugno ◽

Joanna Wierońska ◽

Andrzej Bojarski ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Synthesis And Characterization ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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