Magnetotunable Hybrid Films of Stratified Iron Oxide Nanoparticles Assembled by the Layer-by-Layer Technique

2011 ◽  
Vol 23 (16) ◽  
pp. 3668-3675 ◽  
Author(s):  
Benoit P. Pichon ◽  
Pierric Louet ◽  
Olivier Felix ◽  
Marc Drillon ◽  
Sylvie Begin-Colin ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Layer By Layer ◽  
Hybrid Films ◽  
Layer Technique ◽  
Layer By Layer Technique

scholarly journals Electrochemical oxidation of salicylic acid at ITO substrates modified with layer-by-layer films of carbon nanotubes and iron oxide nanoparticles

2017 ◽  
Vol 805 ◽  
pp. 53-59 ◽  
Author(s):  
Camila de L. Ribeiro ◽  
João Guilherme M. Santos ◽  
Jurandir R. de Souza ◽  
Marcelo A. Pereira-da-Silva ◽  
Leonardo G. Paterno
Keyword(s):  
Carbon Nanotubes ◽  
Salicylic Acid ◽  
Iron Oxide ◽  
Electrochemical Oxidation ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Layer By Layer

Photoswitchable Magnetic Layer-by-Layer Films Consisting of Azobenzene Derivatives and Iron Oxide Nanoparticles

2005 ◽  
Vol 34 (7) ◽  
pp. 1028-1029 ◽  
Author(s):  
Masayuki Suda ◽  
Yasuo Miyazaki ◽  
Yuki Hagiwara ◽  
Osamu Sato ◽  
Seimei Shiratori ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Layer ◽  
Oxide Nanoparticles ◽  
Layer By Layer ◽  
Azobenzene Derivatives

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Sign in / Sign up

Export Citation Format

Share Document