One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol−Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging

2010 ◽  
Vol 22 (12) ◽  
pp. 3768-3772 ◽  
Author(s):  
Koichiro Hayashi ◽  
Kenji Ono ◽  
Hiromi Suzuki ◽  
Makoto Sawada ◽  
Makoto Moriya ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Click Reaction ◽  
Magnetic Hyperthermia ◽  
Resonance Imaging ◽  
One Pot

scholarly journals Functionalization of Magnetic Nanoparticles by Folate as Potential MRI Contrast Agent for Breast Cancer Diagnostics

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4053
Author(s):  
Hamid Heydari Sheikh Hossein ◽  
Iraj Jabbari ◽  
Atefeh Zarepour ◽  
Ali Zarrabi ◽  
Milad Ashrafizadeh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Cancer Diagnostics ◽  
Mri Contrast Agent ◽  
Resonance Imaging ◽  
Ir Transmission ◽  
Average Size ◽  
Coating Agents

In recent years, the intrinsic magnetic properties of magnetic nanoparticles (MNPs) have made them one of the most promising candidates for magnetic resonance imaging (MRI). This study aims to evaluate the effect of different coating agents (with and without targeting agents) on the magnetic property of MNPs. In detail, iron oxide nanoparticles (IONPs) were prepared by the polyol method. The nanoparticles were then divided into two groups, one of which was coated with silica (SiO2) and hyperbranched polyglycerol (HPG) (SPION@SiO2@HPG); the other was covered by HPG alone (SPION@HPG). In the following section, folic acid (FA), as a targeting agent, was attached on the surface of nanoparticles. Physicochemical properties of nanostructures were characterized using Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and a vibrating sample magnetometer (VSM). TEM results showed that SPION@HPG was monodispersed with the average size of about 20 nm, while SPION@SiO2@HPG had a size of about 25 nm. Moreover, HPG coated nanoparticles had much lower magnetic saturation than the silica coated ones. The MR signal intensity of the nanostructures showed a relation between increasing the nanoparticle concentrations inside the MCF-7 cells and decreasing the signal related to the T2 relaxation time. The comparison of coating showed that SPION@SiO2@HPG (with/without a targeting agent) had significantly higher r2 value in comparison to Fe3O4@HPG. Based on the results of this study, the Fe3O4@SiO2@HPG-FA nanoparticles have shown the best magnetic properties, and can be considered promising contrast agents for magnetic resonance imaging applications.

scholarly journals Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019 ◽  
Vol 5 (4) ◽  
pp. 55 ◽  
Author(s):  
Hosu ◽  
Tertis ◽  
Cristea
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Cancer Detection ◽  
Imaging Technique ◽  
Antineoplastic Drugs ◽  
Resonance Imaging ◽  
Sensing Systems

During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

scholarly journals Magnetic Resonance Imaging of Mesenchymal Stem Cells Homing to Pulmonary Metastases Using Biocompatible Magnetic Nanoparticles

2009 ◽  
Vol 69 (23) ◽  
pp. 8862-8867 ◽  
Author(s):  
Michael R. Loebinger ◽  
Panagiotis G. Kyrtatos ◽  
Mark Turmaine ◽  
Anthony N. Price ◽  
Quentin Pankhurst ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Pulmonary Metastases ◽  
Resonance Imaging

Nanotexaphyrin: One-Pot Synthesis of a Manganese Texaphyrin-Phospholipid Nanoparticle for Magnetic Resonance Imaging

2016 ◽  
Vol 55 (21) ◽  
pp. 6187-6191 ◽  
Author(s):  
Joseph M. Keca ◽  
Juan Chen ◽  
Marta Overchuk ◽  
Nidal Muhanna ◽  
Christina M. MacLaughlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
One Pot ◽  
One Pot Synthesis

Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles

2005 ◽  
Vol 53 (5) ◽  
pp. 999-1005 ◽  
Author(s):  
Charles H. Cunningham ◽  
Takayasu Arai ◽  
Phillip C. Yang ◽  
Michael V. McConnell ◽  
John M. Pauly ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Positive Contrast ◽  
Resonance Imaging ◽  
Contrast Magnetic Resonance Imaging ◽  
Contrast Magnetic Resonance
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