An Integrated Approach to Ligand- and Structure-Based Drug Design: Development and Application to a Series of Serine Protease Inhibitors

Orazio Nicolotti; Teresa Fabiola Miscioscia; Andrea Carotti; Francesco Leonetti; Angelo Carotti

doi:10.1021/ci800015s

An Integrated Approach to Ligand- and Structure-Based Drug Design: Development and Application to a Series of Serine Protease Inhibitors

Journal of Chemical Information and Modeling ◽

10.1021/ci800015s ◽

2008 ◽

Vol 48 (6) ◽

pp. 1211-1226 ◽

Cited By ~ 39

Author(s):

Orazio Nicolotti ◽

Teresa Fabiola Miscioscia ◽

Andrea Carotti ◽

Francesco Leonetti ◽

Angelo Carotti

Keyword(s):

Drug Design ◽

Serine Protease ◽

Protease Inhibitors ◽

Integrated Approach ◽

Serine Protease Inhibitors ◽

Design Development ◽

Structure Based Drug Design

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ChemInform Abstract: An Integrated Approach to Lignad- and Structure-Based Drug Design: Development and Application to a Series of Serine Protease Inhibitors.

ChemInform ◽

10.1002/chin.200835215 ◽

2008 ◽

Vol 39 (35) ◽

Author(s):

Orazio Nicolotti ◽

Teresa Fabiola Miscioscia ◽

Andrea Carotti ◽

Francesco Leonetti ◽

Angelo Carotti

Keyword(s):

Drug Design ◽

Serine Protease ◽

Protease Inhibitors ◽

Integrated Approach ◽

Serine Protease Inhibitors ◽

Design Development ◽

Structure Based Drug Design

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CONFORMATIONAL ANALYSIS OF SERINE PROTEASE INHIBITORS AND ITS APPLICATIONS FOR DRUG DESIGN

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1990.tb14444.x ◽

1990 ◽

Vol 42 (S1) ◽

pp. 71P-71P ◽

Cited By ~ 4

Author(s):

K. S. Wibley ◽

D. J. Barlow

Keyword(s):

Drug Design ◽

Conformational Analysis ◽

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors

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The Conformational Analysis of Serine Protease Inhibitors and Its Applications for Drug Design

Journal of Enzyme Inhibition ◽

10.3109/14756369109069075 ◽

1991 ◽

Vol 5 (4) ◽

pp. 331-338 ◽

Cited By ~ 4

Author(s):

K. S. Wibley And ◽

D. J. Barlow

Keyword(s):

Drug Design ◽

Conformational Analysis ◽

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors

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Effect of serine protease inhibitors on the expression of cell surface and soluble forms of two types of tumor necrosis factor receptors

Immunology Letters ◽

10.1016/s0165-2478(97)87943-6 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 276

Author(s):

E Pócsik

Keyword(s):

Tumor Necrosis Factor ◽

Cell Surface ◽

Serine Protease ◽

Protease Inhibitors ◽

Tumor Necrosis ◽

Serine Protease Inhibitors ◽

Tumor Necrosis Factor Receptors ◽

Necrosis Factor

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Detection and analysis of hepatitis C virus NS3 serine protease inhibitors

Journal of Hepatology ◽

10.1016/s0168-8278(01)80459-1 ◽

2001 ◽

Vol 34 (0) ◽

pp. 126-127

Author(s):

R Zemel

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors

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Serine protease inhibitors from Amazon leguminosae seeds: purification and preliminary characterization of two chymotrypsin inhibitors from Inga umbratica

Protein and Peptide Letters ◽

10.2174/0929866013409175 ◽

2001 ◽

Vol 8 (6) ◽

pp. 485-493 ◽

Cited By ~ 8

Author(s):

A. Calderon ◽

R. Teles ◽

J.R. Leite ◽

Jr Bloch ◽

S. Astolfi-Filho ◽

...

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors ◽

Preliminary Characterization ◽

Chymotrypsin Inhibitors

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Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales

Current Topics in Medicinal Chemistry ◽

10.2174/1568026615666150915121447 ◽

2016 ◽

Vol 16 (13) ◽

pp. 1506-1529 ◽

Cited By ~ 8

Author(s):

Guyan Liang ◽

J. Phillip Bowen

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Therapeutic Agents ◽

Serine Protease Inhibitors ◽

Unique Structure

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A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)47363-8 ◽

1991 ◽

Vol 266 (26) ◽

pp. 17230-17235 ◽

Cited By ~ 1

Author(s):

E.P. Clarke ◽

G.A. Cates ◽

E.H. Ball ◽

B.D. Sanwal

Keyword(s):

Endoplasmic Reticulum ◽

Serine Protease ◽

Protease Inhibitors ◽

Binding Protein ◽

Serine Protease Inhibitors ◽

Collagen Binding

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Synergistic effect of serine protease inhibitors and a bothropic antivenom in reducing local hemorrhage and coagulopathy caused by Bothrops jararaca venom

Toxicon ◽

10.1016/j.toxicon.2021.06.009 ◽

2021 ◽

Author(s):

G.M. Silva ◽

D.H. Berto ◽

C.A. Lima ◽

K.B. Waitman ◽

C.F.G. Lima ◽

...

Keyword(s):

Synergistic Effect ◽

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors ◽

Bothrops Jararaca

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Calpain Inhibitors and Serine Protease Inhibitors Can Produce Apoptosis in HL-60 Cells

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1996.0443 ◽

1996 ◽

Vol 334 (1) ◽

pp. 175-181 ◽

Cited By ~ 33

Author(s):

Qin Lu ◽

Ronald L. Mellgren

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Serine Protease Inhibitors ◽

Calpain Inhibitors

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