Rational Approaches for the Design of Effective Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitors

Sergio R. Ribone; Mario A. Quevedo; Marcela Madrid; Margarita C. Briñón

doi:10.1021/ci1001636

Rational Approaches for the Design of Effective Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitors

Journal of Chemical Information and Modeling ◽

10.1021/ci1001636 ◽

2010 ◽

Vol 51 (1) ◽

pp. 130-138 ◽

Cited By ~ 12

Author(s):

Sergio R. Ribone ◽

Mario A. Quevedo ◽

Marcela Madrid ◽

Margarita C. Briñón

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.36.12.2664 ◽

1992 ◽

Vol 36 (12) ◽

pp. 2664-2669 ◽

Cited By ~ 151

Author(s):

B A Larder

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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Etravirine and Rilpivirine: Nonnucleoside Reverse Transcriptase Inhibitors with Activity Against Human Immunodeficiency Virus Type 1 Strains Resistant to Previous Nonnucleoside Agents

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy ◽

10.1592/phco.29.3.281 ◽

2009 ◽

Vol 29 (3) ◽

pp. 281-294 ◽

Cited By ~ 32

Author(s):

Patricia Pecora Fulco ◽

Ian R McNicholl

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.88.19.8806 ◽

1991 ◽

Vol 88 (19) ◽

pp. 8806-8810 ◽

Cited By ~ 138

Author(s):

D. L. Romero ◽

M. Busso ◽

C. K. Tan ◽

F. Reusser ◽

J. R. Palmer ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors.

Journal of Virology ◽

10.1128/jvi.71.8.6271-6275.1997 ◽

1997 ◽

Vol 71 (8) ◽

pp. 6271-6275 ◽

Cited By ~ 172

Author(s):

P Gupta ◽

J Mellors ◽

L Kingsley ◽

S Riddler ◽

M K Singh ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Viral Load ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

High Viral Load ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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Pyrido [1,2a] Indole Derivatives Identified as Novel Nonnucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1

Antiviral Chemistry and Chemotherapy ◽

10.1177/095632029901000204 ◽

1999 ◽

Vol 10 (2) ◽

pp. 79-86 ◽

Cited By ~ 21

Author(s):

DL Taylor ◽

PS Ahmed ◽

P Chambers ◽

AS Tyms ◽

J Bedard ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Indole Derivatives ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00581-11 ◽

2011 ◽

Vol 55 (7) ◽

pp. 3645-3645

Author(s):

Philippe Selhorst ◽

Ana C. Vazquez ◽

Katty Terrazas-Aranda ◽

Johan Michiels ◽

Katleen Vereecken ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Cross Resistance ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.

Journal of Virology ◽

10.1128/jvi.70.6.3698-3705.1996 ◽

1996 ◽

Vol 70 (6) ◽

pp. 3698-3705 ◽

Cited By ~ 22

Author(s):

R A Olmsted ◽

D E Slade ◽

L A Kopta ◽

S M Poppe ◽

T J Poel ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Broad Spectrum ◽

Drug Resistant ◽

Reverse Transcriptase Inhibitors ◽

Nonnucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus ◽

Hiv 1

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Current Status of the Non-nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1

Current Topics in Medicinal Chemistry ◽

10.2174/1568026043388420 ◽

2004 ◽

Vol 4 (9) ◽

pp. 921-944 ◽

Cited By ~ 87

Author(s):

J. Balzarini

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Current Status ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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Human Immunodeficiency Virus Type 1 Non-Nucleoside Reverse Transcriptase Inhibitors

Antiviral Research ◽

10.1128/9781555815493.ch3 ◽

2014 ◽

pp. 33-50 ◽

Cited By ~ 1

Author(s):

Dirk Jochmans ◽

Johan Vingerhoets ◽

Eric Arnoult ◽

Luc Geeraert ◽

Jérôme Guillemont

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

Download Full-text

ChemInform Abstract: Synthesis and Antiviral Activity of 4-Benzyl Pyridinone Derivatives as Potent and Selective Non-Nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors.

ChemInform ◽

10.1002/chin.200110130 ◽

2001 ◽

Vol 32 (10) ◽

pp. no-no

Author(s):

Valerie Dolle ◽

Chi Hung Nguyen ◽

Michel Legraverend ◽

Anne-Marie Aubertin ◽

Andre Kirn ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Antiviral Activity ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Reverse Transcriptase Inhibitors ◽

Immunodeficiency Virus

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