Calculating Similarities between Biological Activities in the MDL Drug Data Report Database

2004 ◽  
Vol 44 (2) ◽  
pp. 727-740 ◽  
Author(s):  
Robert P. Sheridan ◽  
Joseph Shpungin
Keyword(s):  
Biological Activities ◽  
Mdl Drug Data Report

Improvement of cytoprotective and antioxidant activity of Rosa canina L. and Salix alba L. by controlled differential sieving process against H2O2-induced oxidative stress in mouse primary splenocytes

2017 ◽  
Vol 87 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
Nidhal Soualeh ◽  
Aliçia Stiévenard ◽  
Elie Baudelaire ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Good Alternative ◽  
Activity Levels ◽  
Salix Alba ◽  
Rosa Canina ◽  
Free Process ◽  
Plant Powders ◽  
Sieving Process

Abstract. In this study, cytoprotective and antioxidant activities of Rosa canina (RC) and Salix alba (SA), medicinal plants, were studied on mouse primary splenocytes by comparing Controlled Differential Sieving process (CDSp), which is a novel green solvent-free process, versus a conventional technique, employing hydroethanolic extraction (HEE). Thus, preventive antioxidant activity of three plant powders of homogeneous particle sizes, 50–100 µm, 100–180 µm and 180–315 µm, dissolved directly in the cellular buffer, were compared to those of hydroethanolic (HE) extract, at 2 concentrations (250 and 500 µg/mL) in H2O2-treated spleen cells. Overall, compared to HE extract, the superfine powders, i. e., fractions < 180 µm, at the lowest concentration, resulted in greater reactive oxygen species (ROS) elimination, increased glutathione peroxidase (GPx) activity and lower malondialdehyde (MDA) production. Better antioxidant and preventive effects in pre-treated cells were found with the superfine powders for SA (i. e., 50–100 µm and 100–180 µm, both p < 0.001), and with the intermediate powder for RC (i. e., 100–180 µm, p < 0.05) versus HE extract. The activity levels of catalase (CAT) and superoxide dismutase (SOD) in pretreated splenocytes exposed to H2O2, albeit reduced, were near to those in unexposed cells, suggesting that pretreatment with the fine powders has relatively restored the normal levels of antioxidant-related enzymes. These findings supported that CDSp improved the biological activities of plants, avoiding the use of organic solvents and thus it could be a good alternative to conventional extraction techniques.

Shape‐controlled silver NPs for shape‐dependent biological activities

2017 ◽  
Vol 12 (9) ◽  
pp. 647-651 ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Abolfazl Yazdanpanah ◽  
Amirbabak Abrishamkar ◽  
Fatholah Moztarzadeh ◽  
Arash Ramedani ◽  
...  
Keyword(s):  
Biological Activities ◽  
Silver Nps ◽  
Shape Controlled

Research into chemistry and biological activities of Prangos Lindl. (Apiaceae) species of Turkey

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
KHC Baser ◽  
B Demirci ◽  
G Ozek ◽  
A Duran ◽  
N Tabanca ◽  
...  
Keyword(s):  
Biological Activities

Studies on the chemical constituents and their biological activities of the fruit of Garcinia multiflora

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
JJ Chen ◽  
CW Ting ◽  
MH Yen ◽  
TL Hwang ◽  
C Peng ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents

Biological Activities of Andrographolide and Some Semi-synthesis Nonbitter Andrographolides

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Aromdee ◽  
N Sriubolmas ◽  
T Ekalaksananan ◽  
C Pientong ◽  
S Seubsasana ◽  
...  
Keyword(s):  
Biological Activities

Chemical analysis and biological activities of methanol extracts from Astragalus gombiformis Pomel (Fabaceae)

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
H Teyeb ◽  
O Houta ◽  
A Lamari ◽  
M Neffati ◽  
W Douki ◽  
...  
Keyword(s):  
Chemical Analysis ◽  
Biological Activities ◽  
Methanol Extracts

Circulating Activities During Constant Infusion of Heparin or a Low Molecular Weight Derivative (Enoxaparine): Failure to Demonstrate any Circadian Variations

1987 ◽  
Vol 58 (04) ◽  
pp. 1068-1072 ◽  
Author(s):  
P Toulon ◽  
J F Vitoux ◽  
C Leroy ◽  
T Lecomte ◽  
M Roncato ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Circadian Rhythm ◽  
Biological Activities ◽  
Constant Infusion ◽  
Low Molecular Weight ◽  
Circadian Variations ◽  
Heparin Cofactor Ii ◽  
Heparin Infusion ◽  
Chromogenic Assay ◽  
Heparin Affinity

SummaryWe compared in six patients successively treated with an unfractionated heparin (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa activity, measured in a chromogenic assay, during a 36 h constant infusion. The values varied in a wider range during UHF infusion, but remained in the therapeutic range except once in one patient. No circadian rhythm could be demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa circulating activities. In both cases, there were no significant modifications of three proteins with high heparin affinity (antithrombin III, heparin cofactor II, histidine-rich glycoprotein).Our results suggest that the circadian rhythm of the biological activities previously observed in patients treated with constant heparin infusion using clotting method is due to other factors than heparin itself.

Turkish Oregano: Chemistry & Biological Activities

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
KHC Baser ◽  
F Demirci
Keyword(s):  
Biological Activities
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