Structural Flexibility of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor:  9-ClTIBOas Explained by Potential Energy Surface and13C and1H NMR Calculations, Based onab initioand Density Functional Study

2003 ◽  
Vol 43 (5) ◽  
pp. 1412-1422 ◽  
Author(s):  
Suwipa Saen-oon ◽  
Supa Hannongbua ◽  
Peter Wolschann
Keyword(s):  
Potential Energy ◽  
Potential Energy Surface ◽  
Reverse Transcriptase ◽  
Density Functional ◽  
Energy Surface ◽  
Transcriptase Inhibitor ◽  
Functional Study ◽  
Structural Flexibility ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

scholarly journals Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mayumi Imahashi ◽  
Hirotaka Ode ◽  
Ayumi Kobayashi ◽  
Michiko Nemoto ◽  
Masakazu Matsuda ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Strand Transfer ◽  
Intestinal Dysbiosis ◽  
Α Diversity ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1 ◽  
Over Time

AbstractIn HIV-1-infected patients, antiretroviral therapy (ART) is a key factor that may impact commensal microbiota and cause the emergence of side effects. However, it is not fully understood how long-term ART regimens have diverse impacts on the microbial compositions over time. Here, we performed 16S ribosomal RNA gene sequencing of the fecal and salivary microbiomes in patients under different long-term ART. We found that ART, especially conventional nucleotide/nucleoside reverse transcriptase inhibitor (NRTI)-based ART, has remarkable impacts on fecal microbial diversity: decreased α-diversity and increased ß-diversity over time. In contrast, dynamic diversity changes in the salivary microbiome were not observed. Comparative analysis of bacterial genus compositions showed a propensity for Prevotella-enriched and Bacteroides-poor gut microbiotas in patients with ART over time. In addition, we observed a gradual reduction in Bacteroides but drastic increases in Succinivibrio and/or Megasphaera under conventional ART. These results suggest that ART, especially NRTI-based ART, has more suppressive impacts on microbiota composition and diversity in the gut than in the mouth, which potentially causes intestinal dysbiosis in patients. Therefore, NRTI-sparing ART, especially integrase strand transfer inhibitor (INSTI)- and/or non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens, might alleviate the burden of intestinal dysbiosis in HIV-1-infected patients under long-term ART.

Conformational Study of the HIV-1 Reverse Transcriptase Inhibitor 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

1999 ◽  
Vol 380 (2) ◽  
Author(s):  
L. Lawtrakul ◽  
S. Hannongbua ◽  
A. Beyer ◽  
P. Wolschann
Keyword(s):  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Conformational Study ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

AbstractThe conformations of the HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT) are calculated by semiempirical and mainly by

Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor

1998 ◽  
Vol 63 (23) ◽  
pp. 8536-8543 ◽  
Author(s):  
Michael E. Pierce ◽  
Rodney L. Parsons ◽  
Lilian A. Radesca ◽  
Young S. Lo ◽  
Stuart Silverman ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Asymmetric Synthesis ◽  
Transcriptase Inhibitor ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1
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