scholarly journals Formulation Development and Drug Delivery Systems for Protein and Peptide Drug Products

1999 ◽  
Vol 77 (34) ◽  
pp. 52
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Peptide Drug ◽  
Formulation Development ◽  
Drug Products

Formulation, Development and Characterization of Floating Beads of Diltiazem Hydrochloride

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anamika Saxena Saxena ◽  
Santosh Kitawat ◽  
Kalpesh Gaur ◽  
Virendra Singh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Repeated Administration ◽  
Alginate Beads ◽  
Delivery Systems ◽  
Sem Analysis ◽  
Formulation Development

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability and better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as copolymers along with sodium alginate.

Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione

2017 ◽  
Vol 523 (1) ◽  
pp. 357-365 ◽  
Author(s):  
Gergely Hetényi ◽  
Janine Griesser ◽  
Michael Moser ◽  
Frédéric Demarne ◽  
Vincent Jannin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protective Effect ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Peptide Drug

Exploring Novel Strategies for Lipid-Based Drug Delivery

2018 ◽  
Vol 3 (1) ◽  
pp. 1-22
Author(s):  
Sabna Kotta ◽  
Navneet Sharma ◽  
Prateek Raturi ◽  
Mohd Aleem ◽  
Rakesh Kumar Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Classification Scheme ◽  
Delivery Systems ◽  
Primary Objective ◽  
Formulation Development ◽  
The Common ◽  
Do So

Currently, the concept of lipid-based drug delivery systems has gained much interest because of their capability to deliver drugs which dissolve sparingly in water or insoluble in nature. Several methods of lipid-based drug delivery exist, and each method has its own advantages as well as limitations. The primary objective of the formulation development is to improve the bioavailability of the drug. The nano-sized lipid-based drug delivery systems have enough potential to do so. This article addresses the various barriers to the transportation of drugs through certain routes and also the common excipients which used to develop the lipid-based drug delivery systems. It provides a thorough overview of the lipid formulation classification scheme (LFCS) and also deals with several formulation & evaluation aspects of lipid-based drug delivery system. Further, it focuses on the formulations which are already available in the market and their regulatory concerns, respectively.

Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery

2015 ◽  
Vol 12 (11) ◽  
pp. 1703-1716 ◽  
Author(s):  
Gintare Leonaviciute ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Peptide Drug

Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems

2017 ◽  
Vol 520 (1-2) ◽  
pp. 267-274 ◽  
Author(s):  
Janine Griesser ◽  
Gergely Hetényi ◽  
Michael Moser ◽  
Frédéric Demarne ◽  
Vincent Jannin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ion Pairing ◽  
Delivery Systems ◽  
Peptide Drug ◽  
Hydrophobic Ion Pairing

Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating

2018 ◽  
Vol 538 (1-2) ◽  
pp. 159-166 ◽  
Author(s):  
Janine Griesser ◽  
Gergely Hetényi ◽  
Hatice Kadas ◽  
Frédéric Demarne ◽  
Vincent Jannin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Peptide Drug

Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release

2015 ◽  
Vol 32 (4) ◽  
pp. 401-407 ◽  
Author(s):  
Reza Mahjub ◽  
Farid Abedin Dorkoosh ◽  
Morteza Rafiee-Tehrani ◽  
Andreas Bernkop Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Peptide Drug
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