Cracking the case of a mysterious plant toxin

2020 ◽  
Vol 98 (30) ◽  
pp. 18-21
Author(s):  
Alla Katsnelson, special to C&EN
Keyword(s):  
Plant Toxin

Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera

Toxicon ◽  
2009 ◽  
Vol 54 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Yan Yuan ◽  
Xiaochang Dai ◽  
Debin Wang ◽  
Xianghui Zeng
Keyword(s):  
Plant Toxin

CCK-8 does not have a differential effect on plant-toxin ingestion in the white-throated woodrat (neotoma albigula).

Appetite ◽  
2007 ◽  
Vol 49 (1) ◽  
pp. 334
Author(s):  
A-M. Torregrossa ◽  
A.V. Azzara ◽  
M.D. Dearing
Keyword(s):  
Differential Effect ◽  
Plant Toxin

scholarly journals Genetics and Bitter Taste Responses to Goitrin, a Plant Toxin Found in Vegetables

2010 ◽  
Vol 35 (8) ◽  
pp. 685-692 ◽  
Author(s):  
S. Wooding ◽  
H. Gunn ◽  
P. Ramos ◽  
S. Thalmann ◽  
C. Xing ◽  
...  
Keyword(s):  
Bitter Taste ◽  
Plant Toxin

scholarly journals Fusogenics

2010 ◽  
Vol 16 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Jeannick Cizeau ◽  
Marianne G. P. Torres ◽  
Sharla G. Cowling ◽  
Stacy Stibbard ◽  
Arjune Premsukh ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Screening Method ◽  
Antibody Fragment ◽  
Vital Role ◽  
Single Step ◽  
Functional Assay ◽  
Plant Toxin ◽  
Promising Alternative ◽  
Pseudomonas Exotoxin A ◽  
Normal Tissues

Antibody-based therapeutics play a vital role in the treatment of certain cancers; however, despite commercial success, various strategies are being pursued to increase their potency and hence improve patient outcomes. The use of antibodies to deliver a cytotoxic payload offers a promising alternative for more efficacious therapies. Immunotoxins are composed of an internalizing antibody fragment linked to a bacterial or plant toxin. Once internalized, the payload, such as Pseudomonas exotoxin A (PE), blocks protein synthesis and induces apoptosis. Typically, immunotoxins are developed by first isolating a tumor-specific antibody, which is then either chemically linked to a toxin or reengineered as a fusion protein. Here, the authors describe the development of Fusogenics, an immunotoxin-based screening method that selects internalizing tumor-specific antibodies using a functional assay. Selected immune library clones were characterized and shown to be selective against normal tissues and specific to tumor tissues. In summary, the Fusogenics immunotoxin platform represents a unique, single-step selection approach combining specificity and functionality to isolate novel internalizing tumor-specific antibody fragments with potential for direct clinical application in the treatment of cancer.

Transcriptomic profile of host response in mouse brain after exposure to plant toxin abrin

Toxicology ◽  
2012 ◽  
Vol 299 (1) ◽  
pp. 33-43 ◽  
Author(s):  
A.S. Bala Bhaskar ◽  
Nimesh Gupta ◽  
P.V. Lakshmana Rao
Keyword(s):  
Mouse Brain ◽  
Host Response ◽  
Plant Toxin ◽  
Transcriptomic Profile

scholarly journals Plant toxin levels in nectar vary spatially across native and introduced populations

2016 ◽  
Vol 104 (4) ◽  
pp. 1106-1115 ◽  
Author(s):  
Paul A. Egan ◽  
Phillip C. Stevenson ◽  
Erin Jo Tiedeken ◽  
Geraldine A. Wright ◽  
Fabio Boylan ◽  
...  
Keyword(s):  
Plant Toxin ◽  
Introduced Populations

Utilisation of ‘omic approaches to improve the identification, diagnosis and treatment of exposure to the plant toxin ricin

Toxicon ◽  
2020 ◽  
Vol 177 ◽  
pp. S31
Author(s):  
Graeme C. Clark ◽  
Stuart Armstrong ◽  
Abbie Harrison ◽  
Karen Moore ◽  
Angela Essex-Lopresti ◽  
...  
Keyword(s):  
Diagnosis And Treatment ◽  
Plant Toxin

scholarly journals Trends of Plant Toxin Food Poisonings during the Past 50 Years in Japan

2014 ◽  
Vol 55 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Miou TODA ◽  
Chikako UNEYAMA ◽  
Fumiko KASUGA
Keyword(s):  
Plant Toxin ◽  
The Past
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