Tailoring Ultraresins Based on the Cross-Linking of Polyethylene Imines. Comparative Investigation of the Chemical Composition, the Swelling, the Mobility, the Chemical Accessibility, and the Performance in Solid-Phase Synthesis of Very High Loaded Resins

2004 ◽  
Vol 6 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Michael Barth ◽  
Jörg Rademann
Keyword(s):  
Chemical Composition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Comparative Investigation ◽  
Cross Linking ◽  
Phase Synthesis ◽  
The Cross ◽  
Very High

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

2003 ◽  
pp. 2244 ◽  
Author(s):  
Toshiyuki Kan ◽  
Yusuke Tominari ◽  
Yuichi Morohashi ◽  
Hideaki Natsugari ◽  
Taisuke Tomita ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Linking ◽  
Phase Synthesis ◽  
Highly Efficient ◽  
Photoaffinity Probes

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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