Solution- and Solid-Phase Strategies for the Design, Synthesis, and Screening of Libraries Based on Natural Product Templates:  A Comprehensive Survey

2001 ◽  
Vol 3 (2) ◽  
pp. 125-150 ◽  
Author(s):  
Dennis G. Hall ◽  
Sukhdev Manku ◽  
Fan Wang
Keyword(s):  
Natural Product ◽  
Solid Phase ◽  
Design Synthesis ◽  
Comprehensive Survey

The Construction of New Proteins. II. Design, Synthesis and Conformational Studies of Folding Units with βαβ-Topology

1986 ◽  
Vol 41 (10) ◽  
pp. 1315-1322 ◽  
Author(s):  
Manfred Mutter ◽  
Karl-Heinz Altmann ◽  
Thomas Vorherr
Keyword(s):  
Solid Phase ◽  
Three Dimensional ◽  
Chemical Properties ◽  
Spectroscopic Studies ◽  
General Concept ◽  
Dimensional Structure ◽  
Design Synthesis ◽  
Phase Synthesis ◽  
Conformational Studies ◽  
Conformational Effects

The design, synthesis and preliminary conformational studies of two polypeptides exhibiting βαβ-type folding topologies are presented. In the design of the model peptides the general concept for the construction of new proteins developed in the preceeding paper was applied. According to this strategy, amphiphilic helices and β-sheets are linked together via hydrophilic loops to attain three-dimensional structures of higher order (‘supersecondary structures’). Com­puter-assisted molecular modelling served as a valuable tool for minimizing conformational con­straints within the molecules. The 38-residue peptide MI was synthesized using polyethylene glycol (PEG) as solubilizing polymeric support (‘Liquid-Phase synthesis'). Conformationally in­duced changes in the physico-chemical properties of the growing peptide chain stressed the significance of conformational effects in peptide synthesis reported earlier. Similar observations were made during the solid-phase synthesis of the 35-peptide MII. CD and IR spectroscopic studies revealed a high degree of secondary structure for both folding units. The present data strongly support the adoption of a three-dimensional structure for both models.

ChemInform Abstract: Design, Synthesis and Diversification of Natural Product-Inspired Hydantoin-Fused Tetrahydroazepino Indoles.

ChemInform ◽  
2016 ◽  
Vol 47 (3) ◽  
Author(s):  
Indrajeet J. Barve ◽  
Prashant B. Dalvi ◽  
Tushar Ulhas Thikekar ◽  
Kaushik Chanda ◽  
Yu-Li Liu ◽  
...  
Keyword(s):  
Natural Product ◽  
Design Synthesis

scholarly journals Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold

2013 ◽  
Vol 51 (6) ◽  
pp. 358-363 ◽  
Author(s):  
Paul S. Baron ◽  
Juliette E. Neve ◽  
David Camp ◽  
Lekha Suraweera ◽  
Ann Lam ◽  
...  
Keyword(s):  
Natural Product ◽  
Design Synthesis ◽  
Spectroscopic Characterisation

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

2009 ◽  
Vol 109 (5) ◽  
pp. 1999-2060 ◽  
Author(s):  
Jyoti P. Nandy ◽  
Michael Prakesch ◽  
Shahriar Khadem ◽  
P. Thirupathi Reddy ◽  
Utpal Sharma ◽  
...  
Keyword(s):  
Natural Product ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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