Solid Phase Extraction Purification of Carboxylic Acid Products from 96-Well Format Solution Phase Synthesis with DOWEX 1×8-400 Formate Anion Exchange Resin

2001 ◽  
Vol 3 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Brett C. Bookser ◽  
Shirong Zhu
Keyword(s):  
Carboxylic Acid ◽  
Solid Phase Extraction ◽  
Exchange Resin ◽  
Anion Exchange Resin ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Extraction ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Dowex 1

Preparative Solid Phase Extraction for the Purification of Levoglucosan Obtained from Lignocellulose

2016 ◽  
Vol 721 ◽  
pp. 82-86 ◽  
Author(s):  
Kristine Meile ◽  
Aivars Zhurinsh
Keyword(s):  
Solid Phase Extraction ◽  
Exchange Resin ◽  
Anion Exchange Resin ◽  
Solid Phase ◽  
Phase Extraction ◽  
Preparative Scale ◽  
Wood Pyrolysis ◽  
Liquid Products ◽  
Basic Anion Exchange Resin ◽  
Basic Anion

Automated preparative scale solid phase extraction (SPE) has been used to separate levoglucosan – a valuable platform chemical from the liquid products of wood pyrolysis. The sorbent for SPE was a strongly basic anion exchange resin in OH-form. Separation of levoglucosan could be done with water as the eluent, the regeneration of the resin was done with a NaCl solution. Up-scaling the purification of levoglucosan is a step forward industrial production of this chemical.

scholarly journals Acid-mediated N-iodosuccinimide-based thioglycoside activation for the automated solution-phase synthesis of α-1,2-linked-rhamnopyranosides

2019 ◽  
Vol 91 (7) ◽  
pp. 1243-1255 ◽  
Author(s):  
Victoria R. Kohout ◽  
Alyssa L. Pirinelli ◽  
Nicola L. B. Pohl
Keyword(s):  
Solid Phase ◽  
Solution Phase ◽  
Phase Extraction ◽  
Phase Synthesis ◽  
Extraction Step ◽  
Solution Phase Synthesis ◽  
Single Coupling ◽  
Activation Conditions ◽  
Glycosylation Reaction ◽  
Solid Phase Extraction Step

Abstract Carbohydrate structures are often complex. Unfortunately, synthesis of the range of sugar combinations precludes the use of a single coupling protocol or set of reagents. Adapting known, reliable bench-chemistry reactions to work via automation will help forward the goal of synthesizing a broad range of glycans. Herein, the preparation of di- and tri-saccharides of alpha 1→2 rhamnan fragments is demonstrated using thioglycoside donors with the development for a solution-phase-based automation platform of commonly used activation conditions using N-iodosuccinimide (NIS) with trimethylsilyl triflate. Byproducts of the glycosylation reaction are shown to be compatible with hydrazine-based deprotection conditions, lending broader functionality to this method as only one fluorous-solid-phase extraction step per coupling/deprotection cycle is required.

Magnetic Solid-Phase Extraction of Drugs and Pesticides from Human Plasma using COOH-mMWCNTs

2020 ◽  
Author(s):  
Heesung Moon ◽  
Jiwon Park ◽  
Jinwoo Hwang ◽  
Heesun Chung
Keyword(s):  
Carbon Nanotubes ◽  
Carboxylic Acid ◽  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
University Hospital ◽  
Phase Extraction ◽  
National University ◽  
Magnetic Solid

Abstract Carbon nanotubes (CNT) are useful for extracting chemical compounds due to their properties, such as surface area and the potential for chemical modification. Especially the formation of carbon nanotubes with carboxylic acid functional group makes them disperse in water-based samples and have strong interaction forces with cationizable analytes. Based on these features, carboxylic acid functionalized multi-walled carbon nanotubes (COOH-MWCNTs) have been used as extraction sorbents. CNT also can be gathered using an external magnet by forming complex with iron oxide (Fe3O4) magnetic nanoparticles (MNPs). In this study, COOH-MWCNTs with MNPs were subjected to magnetic solid phase extraction (mSPE) in order to extract the targeted substances such as diphenhydramine, doxylamine, tramadol, escitalopram, zolpidem, diphenamid, paclobutrazol, hexaconazole, cyproconazole, and mepronil from human plasma samples. The following five factors were optimized: [1] the ratio of COOH-MWCNTs to MNPs as a sorbent from 1: 1 to 1: 4; [2] sorbent amount starting from 12.5% to 75%; [3] sample pH tested pH 2 to pH 10 with 1 N hydrochloride and 1 N sodium hydroxide; [4] agitating time from 0 min to 4 min; [5] elution solvent. LOD of 10 targeted substances in human plasma were in the range of 0.1 to 0.4 mg/L. The recovery of targeted substances (except diphenamid) in human plasma was 73.06–110.28% for intra-day, 83.00–107.70% for inter-day and the precision (RSD, %) in human plasma was 0.3–13.3% for intra-day, 2.9–15.6%. The method was applied to 9 authentic biological samples from overdose patients in the emergency room of Chung-nam National University Hospital. The performance of mSPE was compared with the liquid–liquid extraction (LLE) method using ethyl acetate. The results showed that the newly developed method in this study can be used for screening analysis in forensic and clinical toxicology.

New, high-capacity carboxylic acid functionalized resins for solid-phase extraction of a broad range of organic compounds

1997 ◽  
Vol 786 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Dianna L. Ambrose ◽  
James S. Fritz ◽  
Michael R. Buchmeiser ◽  
Norbert Atzl ◽  
Günther K. Bonn
Keyword(s):  
Carboxylic Acid ◽  
Solid Phase Extraction ◽  
Organic Compounds ◽  
Solid Phase ◽  
High Capacity ◽  
Phase Extraction
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