Solid-Phase Synthesis of Bis-Heterocyclic Compounds from Resin-Bound Orthogonally Protected Lysine

2001 ◽  
Vol 3 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Adel Nefzi ◽  
Marc A. Giulianotti ◽  
Richard A. Houghten
Keyword(s):  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

2003 ◽  
Vol 1 (11) ◽  
pp. 1909 ◽  
Author(s):  
Colin L. Gibson ◽  
Salvatore La Rosa ◽  
Colin J. Suckling
Keyword(s):  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-Phase Traceless Synthesis of Selected Nitrogen-Containing Heterocyclic Compounds. The Encore Technique for Directed Sorting of Modular Solid Support

2001 ◽  
Vol 66 (7) ◽  
pp. 1078-1106 ◽  
Author(s):  
Viktor Krchňák ◽  
Jennifer Smith ◽  
Josef Vágner
Keyword(s):  
Drug Discovery ◽  
Hydrogen Atom ◽  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
Combinatorial Synthesis ◽  
Target Compound ◽  
Phase Synthesis ◽  
Acidic Reagent

The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled on a solid-phase support derivatized with either a benzylamine or a benzhydrylamine linker. Exposure to an acidic reagent caused cleavage of the C(benzyl)-N(aniline) bond, releasing the product with only a hydrogen atom on the descending nitrogen. The Encore technique for directed sorting on SynPhase Lanterns has been developed and applied to combinatorial synthesis of generic drug discovery libraries.

Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles

2009 ◽  
Vol 62 (3) ◽  
pp. 208 ◽  
Author(s):  
Mohammed Abid ◽  
Béla Török ◽  
Xudong Huang
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Significant Contribution ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Reaction Rates ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Reaction Media

Over the years, microwave-assisted organic synthesis (MAOS) became a commonly applied mainstream tool for the synthesis of heterocyclic compounds. The broad range of emerging applications in this field is mainly due to the significant contribution of MAOS to the development of ecofriendly processes. Various transformations have been developed for the synthesis of N-heterocycles under microwave conditions, including fast and selective processes. Tandem reactions involving greener reaction media, solvent-free conditions, and solid-phase synthesis are of exceptional interest in this area. In most transformations, microwave conditions dramatically enhanced reaction rates, as well as provided improved yields. This account highlights the most recent advancements in MAOS-based tandem processes for the synthesis of N-heterocycles.

Corrigendum to: Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles

2009 ◽  
Vol 62 (4) ◽  
pp. 392
Author(s):  
Mohammed Abid ◽  
Béla Török ◽  
Xudong Huang
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Significant Contribution ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Reaction Rates ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Reaction Media

Over the years, microwave-assisted organic synthesis (MAOS) became a commonly applied mainstream tool for the synthesis of heterocyclic compounds. The broad range of emerging applications in this field is mainly due to the significant contribution of MAOS to the development of ecofriendly processes. Various transformations have been developed for the synthesis of N-heterocycles under microwave conditions, including fast and selective processes. Tandem reactions involving greener reaction media, solvent-free conditions, and solid-phase synthesis are of exceptional interest in this area. In most transformations, microwave conditions dramatically enhanced reaction rates, as well as provided improved yields. This account highlights the most recent advancements in MAOS-based tandem processes for the synthesis of N-heterocycles.

scholarly journals Solid Phase Synthesis of Heterocyclic Compounds

1998 ◽  
Vol 56 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Yoshinori KONDO ◽  
Hisashi SHINKAI ◽  
Ken-ichi TANJI
Keyword(s):  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas

1997 ◽  
Vol 38 (6) ◽  
pp. 931-934 ◽  
Author(s):  
Adel Nefzi ◽  
John M. Ostresh ◽  
Jean-Philippe Meyer ◽  
Richard A. Houghten
Keyword(s):  
Heterocyclic Compounds ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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