G-Protein-Coupled Receptor Trafficking: Understanding the Chemical Basis of Health and Disease

2006 ◽  
Vol 1 (10) ◽  
pp. 631-638 ◽  
Author(s):  
Alfredo Ulloa-Aguirre ◽  
Jo Ann Janovick ◽  
Alfredo Leaños Miranda ◽  
P. Michael Conn
Keyword(s):  
G Protein ◽  
Receptor Trafficking ◽  
G Protein Coupled Receptor ◽  
Chemical Basis ◽  
Health And Disease ◽  
G Protein Coupled

The ins and outs of G protein-coupled receptor trafficking

2003 ◽  
Vol 28 (7) ◽  
pp. 369-376 ◽  
Author(s):  
Adriano Marchese ◽  
Catherine Chen ◽  
You-Me Kim ◽  
Jeffrey L. Benovic
Keyword(s):  
G Protein ◽  
Receptor Trafficking ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Regulation of G protein-coupled receptor trafficking

2007 ◽  
Vol 190 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Z. -Q. D. Xu ◽  
X. Zhang ◽  
L. Scott
Keyword(s):  
G Protein ◽  
Receptor Trafficking ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Ting Zhang ◽  
Malgorzata A. Garstka ◽  
Ke Li
Keyword(s):  
Animal Models ◽  
G Protein ◽  
Cellular Localization ◽  
G Protein Coupled Receptor ◽  
C5a Receptor ◽  
Intracellular Signals ◽  
Health And Disease ◽  
Anti Inflammatory ◽  
G Protein Coupled

After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro- or anti-inflammatory role of C5aR2 in animal models of diverse diseases makes one bewildered. This review summarizes reports on C5aR2, tries to clear up available evidence on these four controversial aspects, and delineates C5aR2 function(s). It also summarizes available toolboxes for C5aR2 study.

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