The 7th Japan-Korea Chemical Biology Symposium: Chemical Biology of Natural Bioactive Molecules

2014 ◽  
Vol 9 (5) ◽  
pp. 1070-1074
Author(s):  
Ramesh Prasad Pandey ◽  
Ho Jeong Kwon ◽  
Jong Seog Ahn ◽  
Hiroyuki Osada ◽  
Jae Kyung Sohng
Keyword(s):  
Chemical Biology ◽  
Bioactive Molecules ◽  
Biology Symposium

scholarly journals Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island

2016 ◽  
Vol 69 (12) ◽  
pp. 885-888 ◽  
Author(s):  
Tilman Schneider-Poetsch ◽  
Shunji Takahashi ◽  
Jae-Hyuk Jang ◽  
Jong Seog Ahn ◽  
Hiroyuki Osada
Keyword(s):  
Chemical Biology ◽  
Small Island ◽  
Biology Symposium

scholarly journals Recent Applications and Developments of Organic Azides in Total Synthesis of Natural Products

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Hiroki Tanimoto ◽  
Kiyomi Kakiuchi
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Chemical Biology ◽  
Organic Reactions ◽  
Bioactive Molecules ◽  
Preparation Methods ◽  
Organic Azides ◽  
Agricultural Areas

Organic azides have been exploited since their discovery because of their high reactivities. Various organic reactions using azides have been synthetically applied in chemical biology pharmaceuticals medicinal and agricultural areas. In this review we present some recent applications and developments of organic azides in the total synthesis of natural products (mostly within five years) especially alkaloids. We focus not only on application examples of organic azides but also show their preparation methods including recently reported procedures concerning their decomposing and reducing methods in the syntheses of bioactive molecules.

2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology

ChemBioChem ◽  
2019 ◽  
Vol 20 (7) ◽  
pp. 968-973
Author(s):  
Marco Lucchino ◽  
Anne Billet ◽  
Antoine Versini ◽  
Harikrishna Bavireddi ◽  
Bhanu‐Das Dasari ◽  
...  
Keyword(s):  
Chemical Biology ◽  
Biology Symposium

scholarly journals HybridMolDB: a manually curated database dedicated to hybrid molecules for chemical biology and drug discovery

2019 ◽  
Author(s):  
Yecheng Li ◽  
Chongze Zhao ◽  
Boyan Wei ◽  
Ling Wang
Keyword(s):  
Drug Discovery ◽  
Chemical Biology ◽  
Bioactive Molecules ◽  
Hybrid Molecule ◽  
Research Activity ◽  
Biological Targets ◽  
Hybrid Molecules ◽  
Pharmacological Data ◽  
Single Chemical ◽  
Structure Similarity

AbstractSummaryHybrid molecule-based drug design is the combination of two or more pharmacophoric moieties from identical or non-identical bioactive molecules, or known identical or non-identical bioactive molecules, into a single chemical entity. This strategy may be used to achieve better affinity and efficacy, or improved properties compared to the parent molecules, to interact with two or multiple targets, to reduce undesirable side effects, to decrease drug-drug interactions or to reduce emergence of drug resistance. The approach offers the prospect of better drugs for the treatment of many human diseases. Research activity in this area is increasing and has attracted many practitioners worldwide. To accelerate the design and discovery of new hybrid molecule-based drugs, it is essential to properly collect and annotate experimental data obtained from known hybrid molecules. To address this need, we have developed HybridMolDB, a manually curated database dedicated to hybrid molecules for chemical biology and drug discovery. It contains structures, manually annotated design protocols, pharmacological data, some physicochemical, ligand efficiency, drug-likeness and ADMET characteristics, and the biological targets of known hybrid molecules. HybridMolDB supports a range of query types, including searches by extensive text, protein sequence, chemical structure similarity and property ranges.AvailabilityHybridMolDB is freely available at http://www.idruglab.com/HybridMolDB/[email protected].

Correction: Graduate Education in Chemical Biology at the University of Michigan

2006 ◽  
Vol 1 (9) ◽  
pp. 601
Author(s):  
Tonia J. Buchholz ◽  
Bruce Palfey ◽  
Anna K. Mapp ◽  
Gary D. Glick
Keyword(s):  
Graduate Education ◽  
Chemical Biology ◽  
University Of Michigan ◽  
The University
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