Technique for the Kinetic Characterization of the Metabolic Reactions of Hepatocytes in Adhesion Culture

1998 ◽  
Vol 14 (3) ◽  
pp. 500-507 ◽  
Author(s):  
G. Catapano ◽  
L. De Bartolo
Keyword(s):  
Kinetic Characterization ◽  
Adhesion Culture ◽  
Metabolic Reactions

Importance of the Kinetic Characterization of Liver Cell Metabolic Reactions to the Design of Hybrid Liver Support Devices

1996 ◽  
Vol 19 (11) ◽  
pp. 670-676 ◽  
Author(s):  
G. Catapano ◽  
L. De Bartolo
Keyword(s):  
Liver Cell ◽  
Kinetic Characterization ◽  
Clinical Scale ◽  
Liver Support ◽  
Metabolic Functions ◽  
Metabolic Reactions ◽  
Liver Support Devices ◽  
Kinetics Of ◽  
Support Devices

Hybrid liver support devices (HLSDs) developed for the treatment of fulminant hepatic failure often perform well on a laboratory scale but rapidly lose their metabolic functions, or are not therapeutically effective, on a clinical scale. This suggests that the procedures adopted so far for the design of HLSDs are susceptible to improvement. In this paper, we discuss how essential a reliable and thorough kinetic characterization of the liver cell metabolic reactions is to the design of a clinically effective membrane HLSD. The features of the bioreactors used for the kinetic characterization of liver cell reactions are presented and discussed on the basis of the multifactorial nature of such reactions. The relevance of kinetics to the design of a membrane HLSD is also discussed with respect to the effect of the kinetics of oxygen consumption on the performance of the device.

Kinetic Characterization of Anticarsia gemmatalis Digestive Serine- Proteases and the Inhibitory Effect of Synthetic Peptides

2018 ◽  
Vol 24 (11) ◽  
Author(s):  
Adriana M. Patarroyo-Vargas ◽  
Yaremis B. Merino-Cabrera ◽  
Jose C. Zanuncio ◽  
Francelina Rocha ◽  
Wellington G. Campos ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Serine Proteases ◽  
Inhibitory Effect ◽  
Anticarsia Gemmatalis ◽  
Kinetic Characterization

scholarly journals Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity.

1987 ◽  
Vol 262 (8) ◽  
pp. 3754-3761
Author(s):  
A.J. Ganzhorn ◽  
D.W. Green ◽  
A.D. Hershey ◽  
R.M. Gould ◽  
B.V. Plapp
Keyword(s):  
Amino Acid ◽  
Substrate Specificity ◽  
Amino Acid Residue ◽  
Kinetic Characterization ◽  
Alcohol Dehydrogenases

Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol

2012 ◽  
Vol 28 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Sara R. Schlesinger ◽  
Britain Bruner ◽  
Patrick J. Farmer ◽  
Sung-Kun Kim
Keyword(s):  
Kinetic Characterization ◽  
Slow Binding Inhibitor

Kinetic characterization of Ca2+-ATPase (SERCA1) inhibition by tri-n-butyltin(IV) chloride. A docking conformation proposal

2014 ◽  
Vol 33 (6) ◽  
pp. 1211-1224
Author(s):  
Scheherezade García-Carrillo ◽  
Francisco J. Aranda ◽  
Antonio Ortiz ◽  
José A. Teruel
Keyword(s):  
Kinetic Characterization
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