Development of Sporulation/Immobilization Method and Its Application for the Continuous Production of Cyclosporin A by Tolypocladium inflatum

1997 ◽  
Vol 13 (5) ◽  
pp. 546-550 ◽  
Author(s):  
T.H. Lee ◽  
G.-T. Chun ◽  
Y.K. Chang
Keyword(s):  
Cyclosporin A ◽  
Continuous Production ◽  
Tolypocladium Inflatum ◽  
Immobilization Method

Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum

Biochemistry ◽  
1986 ◽  
Vol 25 (3) ◽  
pp. 550-553 ◽  
Author(s):  
Rainer Zocher ◽  
Takuya Nihira ◽  
Edith Paul ◽  
Norbert Madry ◽  
Hugo Peeters ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Partial Purification ◽  
Tolypocladium Inflatum ◽  
Multifunctional Enzyme ◽  
Purification And Properties

Cyclosporin-A production by Tolypocladium inflatum using solid state fermentation

1999 ◽  
Vol 34 (3) ◽  
pp. 269-280 ◽  
Author(s):  
M.V. Ramana Murthy ◽  
E.V.S. Mohan ◽  
A.K. Sadhukhan
Keyword(s):  
Solid State ◽  
Cyclosporin A ◽  
Solid State Fermentation ◽  
Tolypocladium Inflatum

Production of cyclosporin a by carrageenan-immobilized tolypocladium inflatum in an airlift reactor with external loop

1983 ◽  
Vol 5 (10) ◽  
pp. 693-696 ◽  
Author(s):  
B. C. Foster ◽  
R. T. Coutts ◽  
F. M. Pasutto ◽  
J. B. Dossetor
Keyword(s):  
Cyclosporin A ◽  
Airlift Reactor ◽  
Tolypocladium Inflatum ◽  
External Loop

scholarly journals Cyclosporine A nephropathy, its pathogenesis and management

KIDNEYS ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 186-189
Author(s):  
Yusuf Erçin Sonmez
Keyword(s):  
Cyclosporin A ◽  
Tissue Oxygenation ◽  
Morphological Changes ◽  
Early Period ◽  
Late Toxicity ◽  
Great Success ◽  
Tolypocladium Inflatum ◽  
Rat Models ◽  
Underlying Factor ◽  
Early Toxicity

CsA, obtained from a fungus called Tolypocladium inflatum came into medical use in 1983. Organ transplants have shown great success after the use of Cyclosporine, especially in 3- and 5-year graft survival. However, nephrotoxicity seen in the early and late periods complicates its use. It is very important to distinguish especially early toxicity from rejection attacks; because the treatments of both processes are completely different. While vasocostriction in the renal artery system is prominent in the early period, the underlying factor for late toxicity is the thickening of the arteriolar intima and the consequent decrease in tissue oxygenation. The article discusses the variants of toxicity caused by the use of cyclosporin A. Morphological changes with the use of cyclosporin A are shown in rat models. The results of our own observations on the use of prostaglandin, which demonstrated the effect of vasodilation, are also presented, which can probably be used for further studies in order to reduce the nephrotoxicity of cyclosporin A. In particular, we found that PGE2 significantly reduced vasoconstriction and reduced the toxic effect due to CsA. The limitations was the usage of these agents once, so we couldn’t continue and only gave them intravenously. However, the results obtained were found to be significant.

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