Temperature Effects on Product-Quality-Related Enzymes in Batch CHO Cell Cultures Producing Recombinant tPA

K.J.R. Clark; F.W.R. Chaplin; S.W. Harcum

doi:10.1021/bp049951x

Temperature Effects on Product-Quality-Related Enzymes in Batch CHO Cell Cultures Producing Recombinant tPA

Biotechnology Progress ◽

10.1021/bp049951x ◽

2004 ◽

Vol 20 (6) ◽

pp. 1888-1892 ◽

Cited By ~ 32

Author(s):

K.J.R. Clark ◽

F.W.R. Chaplin ◽

S.W. Harcum

Keyword(s):

Product Quality ◽

Cell Cultures ◽

Temperature Effects ◽

Cho Cell

Download Full-text

STEP® vectors for rapid generation of stable transfected CHO cell pools and clones with high expression levels and product quality homogeneity of difficult-to-express proteins

Protein Expression and Purification ◽

10.1016/j.pep.2021.105920 ◽

2021 ◽

pp. 105920

Author(s):

Abhinav Luthra ◽

Remco A. Spanjaard ◽

Sarwat Cheema ◽

Nathalie Veith ◽

Lars Kober ◽

...

Keyword(s):

Product Quality ◽

High Expression ◽

Cho Cell ◽

Expression Levels ◽

Rapid Generation

Download Full-text

Monitoring CHO cell cultures: Cell stress and early apoptosis assessment by mass spectrometry

Journal of Biotechnology ◽

10.1016/j.jbiotec.2013.10.014 ◽

2013 ◽

Vol 168 (4) ◽

pp. 452-461 ◽

Cited By ~ 12

Author(s):

Sebastian Schwamb ◽

Bogdan Munteanu ◽

Björn Meyer ◽

Carsten Hopf ◽

Mathias Hafner ◽

...

Keyword(s):

Mass Spectrometry ◽

Cell Cultures ◽

Cell Stress ◽

Cho Cell ◽

Early Apoptosis

Download Full-text

A Comparative Transcriptomics Workflow for Analyzing Microarray Data From CHO Cell Cultures

Biotechnology Journal ◽

10.1002/biot.201700228 ◽

2017 ◽

Vol 13 (3) ◽

pp. 1700228 ◽

Cited By ~ 3

Author(s):

Chun Chen ◽

Huong Le ◽

Brian Follstad ◽

Chetan T. Goudar

Keyword(s):

Cell Cultures ◽

Microarray Data ◽

Comparative Transcriptomics ◽

Cho Cell

Download Full-text

Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures

Biotechnology and Bioengineering ◽

10.1002/bit.28013 ◽

2021 ◽

Author(s):

Dongil Kim ◽

Chansik Yoon ◽

Gyun Min Lee

Keyword(s):

Cell Cultures ◽

Small Molecule ◽

Antibody Production ◽

Recombinant Antibody ◽

Cho Cell ◽

Recombinant Antibody Production

Download Full-text

CHO Cell Engineering for Improved Process Performance and Product Quality

Cell Culture Engineering ◽

10.1002/9783527811410.ch9 ◽

2019 ◽

pp. 207-250

Author(s):

Simon Fischer ◽

Kerstin Otte

Keyword(s):

Product Quality ◽

Cell Engineering ◽

Process Performance ◽

Cho Cell

Download Full-text

Metabolic flux analysis during galactose and lactate co-consumption reveals enhanced energy metabolism in continuous CHO cell cultures

Chemical Engineering Science ◽

10.1016/j.ces.2019.04.049 ◽

2019 ◽

Vol 205 ◽

pp. 201-211 ◽

Cited By ~ 1

Author(s):

Mauro Torres ◽

Julio Berrios ◽

Yandi Rigual ◽

Yesenia Latorre ◽

Mauricio Vergara ◽

...

Keyword(s):

Energy Metabolism ◽

Cell Cultures ◽

Metabolic Flux Analysis ◽

Metabolic Flux ◽

Flux Analysis ◽

Cho Cell

Download Full-text

Can feeding lactate be beneficial to CHO cell cultures?

Biotechnology and Bioengineering ◽

10.1002/bit.24290 ◽

2012 ◽

Vol 109 (5) ◽

pp. fmvi-fmvi

Keyword(s):

Cell Cultures ◽

Cho Cell

Download Full-text

Modeling and control of amino acid starvation-induced apoptosis in CHO cell cultures

Proceedings of the 2002 American Control Conference (IEEE Cat. No.CH37301) ◽

10.1109/acc.2002.1023247 ◽

2002 ◽

Cited By ~ 2

Author(s):

L. Simon ◽

M.N. Karim

Keyword(s):

Amino Acid ◽

Cell Cultures ◽

Amino Acid Starvation ◽

Cho Cell ◽

Modeling And Control ◽

Induced Apoptosis ◽

And Control

Download Full-text

Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures

Biotechnology and Bioengineering ◽

10.1002/bit.26384 ◽

2017 ◽

Vol 114 (12) ◽

pp. 2717-2728 ◽

Cited By ~ 23

Author(s):

Zhuangrong Huang ◽

Dong-Yup Lee ◽

Seongkyu Yoon

Keyword(s):

Cell Cultures ◽

Cho Cell

Download Full-text

Interactions of Chinese Hamster Ovary (CHO) cell cultures with second generation expanded bed adsorbents

Separation and Purification Technology ◽

10.1016/j.seppur.2015.02.014 ◽

2015 ◽

Vol 144 ◽

pp. 23-30 ◽

Cited By ~ 6

Author(s):

Prasad Babu Kakarla ◽

Roy N. DSouza ◽

Urve Toots ◽

Marcelo Fernández-Lahore

Keyword(s):

Cell Cultures ◽

Chinese Hamster Ovary ◽

Second Generation ◽

Chinese Hamster ◽

Cho Cell ◽

Expanded Bed

Download Full-text