A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes

1992 ◽  
Vol 8 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Augustinus Bader ◽  
Inne H. Borel Rinkes ◽  
Ellen I. Closs ◽  
Colleen M. Ryan ◽  
Mehmet Toner ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Culture System ◽  
Human Hepatocytes ◽  
Phase Response ◽  
Hepatocyte Culture ◽  
Cytokine Stimulation ◽  
Stimulation Of

The initial acute phase response predicts long-term stroke recovery

1998 ◽  
Vol 7 (2) ◽  
pp. 128-131 ◽  
Author(s):  
Wayne M. Clark ◽  
Nancy B. Beamer ◽  
Michael Wynn ◽  
Bruce M. Coull
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Stroke Recovery

Acute-phase response of human hepatocytes after infection with Chlamydia pneumoniae and cytomegalovirus

2003 ◽  
Vol 33 (8) ◽  
pp. 720-725 ◽  
Author(s):  
M. S. A. Verkerk ◽  
F. L. J. Visseren ◽  
K. Paul Bouter ◽  
R. J. A. Diepersloot
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Chlamydia Pneumoniae ◽  
Human Hepatocytes ◽  
Phase Response

Stimulation of Hepatic Acute Phase Response by Cytokines and Glucocorticoidsa

2008 ◽  
Vol 557 (1) ◽  
pp. 280-296 ◽  
Author(s):  
H. BAUMANN ◽  
K. R. PROWSE ◽  
S. MARINKOVIĆ ◽  
K-A. WON ◽  
G. P. JAHREIS
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Stimulation Of

Long-Term Ethanol Exposure Decreases the Endotoxin-Induced Hepatic Acute Phase Response in Rats

2017 ◽  
Vol 41 (3) ◽  
pp. 562-570 ◽  
Author(s):  
Emilie Glavind ◽  
Hendrik Vilstrup ◽  
Henning Grønbaek ◽  
Stephen Hamilton-Dutoit ◽  
Nils Erik Magnusson ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Ethanol Exposure ◽  
Phase Response

Acute Phase Response After Zoledronic Acid is Associated with Long-Term Effects on White Blood Cells

2013 ◽  
Vol 93 (3) ◽  
pp. 249-252 ◽  
Author(s):  
Maurizio Rossini ◽  
Silvano Adami ◽  
Ombretta Viapiana ◽  
Gaia Tripi ◽  
Roberta Zanotti ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Acute Phase ◽  
Blood Cells ◽  
Acute Phase Response ◽  
White Blood Cells ◽  
Phase Response ◽  
Long Term Effects

Prostaglandins E2 and F2α are not involved in the monocytic-product (interleukin-1)-induced stimulation of hepatic fibrinogen synthesis in rats

1988 ◽  
Vol 74 (5) ◽  
pp. 477-483 ◽  
Author(s):  
J. C. W. M. Holtslag ◽  
H. J. Moshage ◽  
J. F. van Pelt ◽  
J. A. G. M. Kleuskens ◽  
F. W. J. Gribnau ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Second Messengers ◽  
Interleukin 1 ◽  
Rat Hepatocytes ◽  
Phase Response ◽  
Mrna Content ◽  
Stimulation Of

1. Monocytic products, especially interleukin-1 (IL-1), play an important role in the acute-phase response. Prostaglandins have been shown to act as second messengers in several physiological alterations of the acute-phase response, such as fever, muscle wasting and immunoregulation. The present study was undertaken to determine the role of prostaglandins in the monocytic-product-induced stimulation of the hepatic synthesis of fibrinogen, a well-known acute-phase protein. 2. Prostaglandin (PG) E2, PGF2α and 16,16-dimethyl-PGE2 did not stimulate fibrinogen synthesis and fibrinogen polypeptide mRNA content when administered intraperitoneally to rats or when added to monolayer cultures of rat hepatocytes. 3. Cyclo-oxygenase inhibitors did not abolish the stimulation of fibrinogen synthesis and its mRNA content induced by monocytic products in vivo or in vitro. 4. These findings indicate that the enhanced synthesis of fibrinogen induced by monocytic products (including IL-1) during the acute-phase response is not mediated by prostaglandins or other products of the cyclo-oxygenase pathway of arachidonic acid.

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

Hepatology ◽  
1990 ◽  
Vol 12 (5) ◽  
pp. 1179-1186 ◽  
Author(s):  
José V. Castell ◽  
Maria José Gómez-lechón ◽  
Martina David ◽  
Ricardo Fabra ◽  
Ramón Trullenque ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Acute Phase Response ◽  
Acute Phase Protein ◽  
Human Hepatocytes ◽  
Phase Response ◽  
Phase Protein

Recovery from the hepatic acute phase response in the severely burned and the effects of long-term growth hormone treatment

Burns ◽  
2004 ◽  
Vol 30 (7) ◽  
pp. 675-679 ◽  
Author(s):  
Suchmor Thomas ◽  
Steven E. Wolf ◽  
David L. Chinkes ◽  
David N. Herndon
Keyword(s):  
Growth Hormone ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Phase Response
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